Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes

Autor: Decio L. Eizirik, Benita Bk Book, Mark D. Pescovitz, Jean Valéry Turatsinze, Ivan Ia Restrepo, Michael Mj Pugia, Eric Ea Wiebke, Teresa Tl Mastracci, Raghavendra G. Mirmira

Publikováno v: Diabetes, Obesity and Metabolism. 20:1859-1867

AIMS Our current understanding of the pathogenesis of type 1 diabetes (T1D) arose, in large part, from studies using the non-obese diabetic (NOD) mouse model. In the present study, we chose a human-focused method to investigate T1D disease mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94625e4fed7ea4d3ca14118ab0b3f2
https://doi.org/10.1111/dom.13298

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Autor: Jay M. Sosenko, D. J. Becker, Kevan C. Herold, E. Leschek, James W. Thomas, Francesco Dotta, Jeffrey L. Mahon, K. Nanto-Salonen, Diane K. Wherrett, Lisa M. Spain, Andrew Muir, Polly J. Bingley, Massimo Trucco, Jeffrey P. Krischer, S. E. Gitelman, Alessandra Mandelli, Mark S. Anderson, Sarah J. Richardson, Peter S. Linsley, Riccardo Bonfanti, Eleonora Bianconi, George S. Eisenbarth, M. Siegelman, J. Peyman, Angela Stabilini, M. Redondo, Bernhard J. Hering, Richard A. Insel, Maurizio De Pellegrin, Franco Meschi, Francesca Ragogna, Mark A. Clements, Lars Krogvold, Mark Peakman, Alberto Pugliese, J. Blum, William E. Russell, P. Chase, Pia Leete, Anette-Gabriele Ziegler, Mark A. Atkinson, Jane H. Buckner, Andrea Rigamonti, Tihamer Orban, Laura Nigi, Philip Raskin, Guido Sebastiani, Louis H. Philipson, Linda A. DiMeglio, Clara Bonura, Manuela Battaglia, Jay S. Skyler, David A. Baidal, Giulio Frontino, Emanuele Bosi, Matthew J. Dufort, Andrea Valle, William E. Winter, Peter A. Gottlieb, C. G. Fathman, Helena Elding Larsson, Robin Goland, Michael J. Clare-Salzler, M. G. Roncarolo, Raphael Clynes, Peter A. Antinozzi, Andrea K. Steck, Mikael Knip, Olli Simell, R. Parkman, Bart O. Roep, Desmond A. Schatz, Henry Rodriguez, Nicola Lo Buono, John M. Wentworth, Andrea Laurenzi, Francesca Mancarella, P. Savage, Jennifer B. Marks, G. Grave, Paola M.V. Rancoita, Federica Vecchio, Åke Lernmark, Darrell M. Wilson, Noel G. Morgan, Thomas W.H. Kay, Francine R. Kaufman, Federica Cugnata, Christophe Benoist, Susan Geyer, Peter G. Colman, Mark D. Pescovitz, Robert S. Sherwin, Gerald T. Nepom, John E. Wagner, Antoinette Moran, Knut Dahl-Jørgensen, Jerry P. Palmer, Kasia Bourcier, Wayne V. Moore, Carla J. Greenbaum, Pauline Grogan

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee5d8b12a49d70a6a58dc2174c69799

Differences in Alloimmune Response Between Elderly and Young Mice

Autor: Erin K. Ward, Eric A. Wiebke, Benita K. Book, Mark D. Pescovitz, George J. Eckert, M.A. Volz

Publikováno v: Transplantation Proceedings. 45:1838-1841

The upper age of renal transplant recipients is rising on the transplant wait list. Age-dependent immune responsiveness to new antigens has not been thoroughly studied. This study used a mouse model of alloantibody response to neoalloantigen to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aea6f46d6925c089a83fad0bb9e8921
https://doi.org/10.1016/j.transproceed.2013.01.006

Poly(ethylene glycol) and poly(N-vinlypyrrolidone) for improved porcine islet cryopreservation

Autor: Yuan Zhou, Mark D. Pescovitz, Richard A. Sidner, Sherly Jules, Yiming Weng, Dong Xie

Publikováno v: Journal of Biomedical Science and Engineering. :263-269

Water-soluble polymers poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP) were used to study cryopreservation of porcine islets. DMSO was used as control. The effects of polymer purity, molecular weight (MW) and concentration on islet via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dee5326d8e7695260f0fdb5c79fc32a
https://doi.org/10.4236/jbise.2012.55033

Effects of the Intensity of Immunosuppressive Therapy on Outcome of Treatment for CMV Disease in Organ Transplant Recipients

Autor: Mark D. Pescovitz, C. C. Gahlemann, Angelo A. Bignamini, Anders Åsberg, Alan G. Jardine, Halvor Rollag, Anders Hartmann, Atul Humar

Publikováno v: American Journal of Transplantation. 10:1881-1888

An effective host immune response, critical for successful control of Cytomegalovirus (CMV) disease in solid organ transplant recipients, is affected by intensity and type of immunosuppressive therapy. We used information prospectively captured in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a84451033c9092365bbfa8d7fe58b58
https://doi.org/10.1111/j.1600-6143.2010.03114.x