Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Mark D. Parker"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
SLC4A11 is the most abundant membrane transport protein in corneal endothelial cells. Its functional presence is necessary to support the endothelial fluid pump that draws fluid from the corneal stroma, preventing corneal edema. Several molecular act
Externí odkaz:
https://doaj.org/article/a0a089e4f3e44727a7006d971e56a00a
Autor:
Clayton T. Brady, Aniko Marshall, Lisa A. Eagler, Thomas M. Pon, Michael E. Duffey, Brian R. Weil, Jennifer K. Lang, Mark D. Parker
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9610 (2024)
Congenital proximal renal tubular acidosis (pRTA) is a rare systemic disease caused by mutations in the SLC4A4 gene that encodes the electrogenic sodium bicarbonate cotransporter, NBCe1. The major NBCe1 protein variants are designated NBCe1-A, NBCe1-
Externí odkaz:
https://doaj.org/article/01c5f14fc82f4398a56022751da9c8bc
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The sodium-bicarbonate cotransporter (NBCe1) has three primary variants: NBCe1-A, -B and -C. NBCe1-A is expressed in renal proximal tubules in the cortical labyrinth, where it is essential for reclaiming filtered bicarbonate, such that NBCe1-A knocko
Externí odkaz:
https://doaj.org/article/88ab2e4eea484109834928cf6c1d73b9
Autor:
Thamer A. Alsufayan, Evan J. Myers, Bianca N. Quade, Clayton T. Brady, Aniko Marshall, Nayem Haque, Michael E. Duffey, Mark D. Parker
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12817 (2021)
In most cell types and heterologous expression systems, the electrogenic sodium-bicarbonate cotransporter NBCe1 operates with a 1Na+–2HCO3− stoichiometry that, given typical transmembrane electrochemical gradients, promotes Na+ and HCO3− influx
Externí odkaz:
https://doaj.org/article/0af818bb1e624e8c8935d8d4f609a240
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 201 (2020)
Monocarboxylate transporter 6 (MCT6; SLC16A5) is a recently studied drug transporter that currently has no annotated endogenous function. Currently, only a handful of compounds have been characterized as substrates for MCT6 (e.g., bumetanide, nategli
Externí odkaz:
https://doaj.org/article/889bee405e80438ba194ce17fd3aef27
Autor:
Zachary J. Schlader, David Hostler, Mark D. Parker, Riana R. Pryor, James W. Lohr, Blair D. Johnson, Christopher L. Chapman
Publikováno v:
Nutrients, Vol 11, Iss 9, p 2087 (2019)
An epidemic of chronic kidney disease (CKD) is occurring in laborers who undertake physical work in hot conditions. Rodent data indicate that heat exposure causes kidney injury, and when this injury is regularly repeated it can elicit CKD. Studies in
Externí odkaz:
https://doaj.org/article/454182dca45549958c9de80b62bddda6
Publikováno v:
Sensors, Vol 13, Iss 1, Pp 984-1003 (2013)
Determining the effective concentration (i.e., activity) of ions in and around living cells is important to our understanding of the contribution of those ions to cellular function. Moreover, monitoring changes in ion activities in and around cells i
Externí odkaz:
https://doaj.org/article/2d6259ae3cef4220b4495a27367ddbe5
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Intracellular pH (pHi) regulation in the brain is important in both physiological and physiopathological conditions because changes in pHi generally result in altered neuronal excitability. In this review, we will cover 4 major areas: [1] The effect
Externí odkaz:
https://doaj.org/article/d72fad96fda44c0fa51b23bc05aa83ab
Autor:
Seong-Ki Lee, Rossana Occhipinti, Fraser J. Moss, Mark D. Parker, Irina I. Grichtchenko, Walter F. Boron
Publikováno v:
Journal of the American Society of Nephrology. 34:40-54
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C990-C1002
Mutations in the H+(OH−) conductor SLC4A11 result in corneal endothelial dystrophy. In previous studies using mouse Slc4a11, we showed that the pK value that governs the intracellular pH dependence of SLC4A11 (pKi) is influenced by extracellular pH