Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark D. Nelms"'
Autor:
Mark D. Nelms, Todor Antonijevic, Caroline Ring, Danni L. Harris, Ronnie Joe Bever, Scott G. Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Stephen W. Edwards, Kristan Markey
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
IntroductionThe U. S. Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP) Tier 1 assays are used to screen for potential endocrine system–disrupting chemicals. A model integrating data from 16 high-throughput screening
Externí odkaz:
https://doaj.org/article/0529ddd8135d47368b8e5584fda41e74
Autor:
Ronnie Joe Bever, Stephen W. Edwards, Todor Antonijevic, Mark D. Nelms, Caroline Ring, Danni Harris, Scott G. Lynn, David Williams, Grace Chappell, Rebecca Boyles, Susan Borghoff, Kristan J. Markey
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: Computational models using data from high-throughput screening assays have promise for prioritizing and screening chemicals for testing under the U.S. Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP). The
Externí odkaz:
https://doaj.org/article/6f5a3717b10f4de28b9874309c93fd28
Autor:
Laura Jean Bierut, Tabitha P. Hendershot, Neal L. Benowitz, K. Michael Cummings, Robin J. Mermelstein, Megan E. Piper, Scott I. Vrieze, Theodore L. Wagener, Mark D. Nelms, Cataia Ives, Deborah Maiese, Carol M. Hamilton, Gary E. Swan
Publikováno v:
Addiction Neuroscience, Vol 7, Iss , Pp 100081- (2023)
The use of standard protocols in studies supports consistent data collection, improves data quality, and facilitates cross-study analyses. Funded by the National Institutes of Health, the PhenX (consensus measures for Phenotypes and eXposures) Toolki
Externí odkaz:
https://doaj.org/article/3c0a6b71090842e78d90c672e506eb01
Autor:
Stephanie H Guarino, Mark D Nelms, David Williams, Amanda M. Brandow, C. Patrick Carroll, Nitya Bakshi, Claudia M Campbell, Deepika S. Darbari, Martha Kenney, Wally R Smith, Jennifer Stinson, William Zempsky, Wayne Huggins, Deborah Maiese, Tabitha Hendershot, Carol Hamilton
Publikováno v:
Blood. 140:8302-8304
Autor:
Stephen W. Edwards, Steve Gutsell, Mark D. Nelms, Jonathan M. Goodman, Timothy E. H. Allen, Paul J. Russell
Publikováno v:
Environmental Science & Technology. 54:7461-7470
Molecular initiating events (MIEs) are key events in adverse outcome pathways that link molecular chemistry to target biology. As they are based on chemistry, these interactions are excellent targets for computational chemistry approaches to in silic
Autor:
Claire L. Mellor, Ann M. Richard, Grace Patlewicz, Steven J. Enoch, Richard S. Judson, Judith M. Madden, Stephen W. Edwards, Mark T. D. Cronin, Mark D. Nelms
Publikováno v:
Comput Toxicol
Computational Toxicology
Computational Toxicology
Adverse Outcome Pathways (AOPs) establish a connection between a molecular initiating event (MIE) and an adverse outcome. Detailed understanding of the MIE provides the ideal data for determining chemical properties required to elicit the MIE. This s
Publikováno v:
Comput Toxicol
Multiple US agencies use acute oral toxicity data in a variety of regulatory contexts. One of the ad-hoc groups that the US Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) established to implement the ICCVAM Strat
Autor:
Mark D. Nelms, Grace Patlewicz
Publikováno v:
Frontiers in Toxicology. 2
The requirements of amended Toxic Substances Control Act (TSCA) stipulates that the US Environmental Protection Agency (US EPA) evaluate existing chemicals and make risk based assessments. There are ~33,000 substances that are active in commerce on t
Autor:
J. Christopher Corton, Jerry Liu, Carlton P. Jones, Beena Vallanat, Mark D. Nelms, Grace Patlewicz, Abigail C. Jackson
Publikováno v:
Metallomics : integrated biometal science. 12(9)
Environmental exposure to metals is known to cause a number of human toxicities including cancer. Metal-responsive transcription factor 1 (MTF-1) is an important component of metal regulation systems in mammalian cells. Here, we describe a novel meth
Autor:
Stephen W. Edwards, Joe Swintek, Mark D. Nelms, Brett R. Blackwell, Daniel L. Villeneuve, Gerald T. Ankley, Kellie A. Fay
Publikováno v:
Toxicological Sciences. 163:500-515
The U.S. Environmental Protection Agency's ToxCast program has screened thousands of chemicals for biological activity, primarily using high-throughput in vitro bioassays. Adverse outcome pathways (AOPs) offer a means to link pathway-specific biologi