Výsledky vyhledávání - "Mark D. Mannie"

Akademický článek

A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)

Autor: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-19 (2020)

Abstract Background Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseases afflicting more th

Externí odkaz: https://doaj.org/article/409f6255a29f4f4bb375295ceec8a6f7

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Akademický článek

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro

Autor: Kayla B. DeOca, Cody D. Moorman, Brandon L. Garcia, Mark D. Mannie

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Low-zone IL-2 signaling is key to understanding how CD4+ CD25high FOXP3+ regulatory T cells (Tregs) exhibit dominance and overgrow conventional effector T cells (Tcons) that typically express lower levels of the IL-2 receptor alpha chain (i.e., CD25)

Externí odkaz: https://doaj.org/article/2e3c7511c287412e98eabfd0854e2734

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Akademický článek

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition

Autor: Cody D. Moorman, Alan D. Curtis, Alexander G. Bastian, Sarah E. Elliott, Mark D. Mannie

Publikováno v: Frontiers in Immunology, Vol 9 (2019)

Previous studies showed that single-chain fusion proteins comprised of GM-CSF and major encephalitogenic peptides of myelin, when injected subcutaneously in saline, were potent tolerogenic vaccines that suppressed experimental autoimmune encephalomye

Externí odkaz: https://doaj.org/article/8fb99d40e7e54d0c9f00a64b6a8bcfa2

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Akademický článek

Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy

Autor: Daniel S. Wilkinson, Debjani Ghosh, Rebecca A. Nickle, Cody D. Moorman, Mark D. Mannie

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

FOXP3+ regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy however requires new techno

Externí odkaz: https://doaj.org/article/ceaf8b6c78884f088075e0ba788dbf01

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Akademický článek

Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis

Autor: Mark D. Mannie, J. Lori Blanchfield, S. M. Touhidul eIslam, Derek J. Abbott

Publikováno v: Frontiers in Immunology, Vol 3 (2012)

Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical strategy for the induction o

Externí odkaz: https://doaj.org/article/80f17742a4f7415bb4cc76b0daed707a

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Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases

Autor: Mushfiquddin Khan, Inderjit Singh, Mark D. Mannie, Je-Seong Won, S.M. Touhidul Islam

Publikováno v: Immunology

Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimeric (HIF‐1α/ HIF‐1β) transcription factor in which the oxygen‐sensitive HIF‐1α subunit regulates gene transcription to mediate adaptive tissue responses to hypoxia. HIF‐1 is a key m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8e7692627a4b42366d739092a3cfbc
https://doi.org/10.1111/imm.13335

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Soluble CD25 imposes a low-zone IL-2 signaling environment that favors competitive outgrowth of antigen-experienced CD25high regulatory and memory T cells

Autor: Rebecca A. Nickle, Kayla B. DeOca, Brandon L. Garcia, Mark D. Mannie

Publikováno v: Cellular Immunology. 384:104664

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06038ec4ed5e9811636b936e22b6f15a
https://doi.org/10.1016/j.cellimm.2023.104664

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Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro

Autor: Brandon L. Garcia, Mark D. Mannie, Cody D. Moorman, Kayla B. DeOca

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe614c47f1f95c4ceed581ce5298530
https://www.frontiersin.org/article/10.3389/fimmu.2020.541619/full

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Tolerogenic vaccines: targeting the antigenic and cytokine niches of FOXP3(+) regulatory T cells

Autor: Cody D. Moorman, Alexander G. Bastian, Kayla B. DeOca, Mark D. Mannie

Publikováno v: Cell Immunol

FOXP3(+) regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b3c6aa322c8f07d6de994398371dc
https://europepmc.org/articles/PMC7444458/

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