Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mark D. Lessard"'
Autor:
Giulia Biancon, Poorval Joshi, Joshua T. Zimmer, Torben Hunck, Yimeng Gao, Mark D. Lessard, Edward Courchaine, Andrew E.S. Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D. Simon, Karla M. Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Mol Cell
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9732eb1548edc00558760338c886ade
https://europepmc.org/articles/PMC8988922/
https://europepmc.org/articles/PMC8988922/
Autor:
Toma Tebaldi, Mark D. Lessard, Joshua T. Zimmer, Gabriella Viero, Poorval Joshi, Valentina Botti, Ashley Qin, Karla M. Neugebauer, Giulia Biancon, Torben Hunck, Rana Gbyli, Lea Kiefer, Andrew Es Barentine, Joerg Bewersdorf, Edward M. Courchaine, Yuanbin Song, Matthew D. Simon, Nils Neuenkirchen, Stephanie Halene, Martin Machyna, Haifan Lin, Amisha Patel, Yimeng Gao
Somatic mutations in splicing factors are of significant interest in myeloid malignancies and other cancers. U2AF1, together with U2AF2, is essential for 3’ splice site recognition. U2AF1 mutations result in aberrant splicing, but the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee3ecf3e301da6963e53d2e34aaabe26
https://doi.org/10.1101/2021.04.22.441020
https://doi.org/10.1101/2021.04.22.441020
Autor:
Yiming Li, Jingyu Wang, Martin J. Booth, Ian M. Dobbie, Yongdeng Zhang, Joerg Bewersdorf, Edward S. Allgeyer, Robin Diekmann, Michael A. Phillips, Kevin Hu, Jonas Ries, George Sirinakis, Mark D. Lessard
Publikováno v:
Nat Protoc
Nature Protocols
Nature Protocols
The development of single-molecule switching (SMS) fluorescence microscopy (also called single-molecule localization microscopy) over the last decade has enabled researchers to image cell biological structures at unprecedented resolution. Using two o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2268a872f31a84caaad0ea38010c8f01
https://ora.ox.ac.uk/objects/uuid:4d285e6d-d2b1-4813-80f5-63f81d404b0c
https://ora.ox.ac.uk/objects/uuid:4d285e6d-d2b1-4813-80f5-63f81d404b0c
Autor:
Lynn Cooley, Thomas Biederer, Francesca Bottanelli, Dong-Ryoung Lee, Mark D. Lessard, Jacopo Antonello, Martin J. Booth, Katherine Watters, Lena K. Schroeder, Phylicia Kidd, Julianne A. Gerdes, Xiang Hao, Joerg Bewersdorf, Jiaxi Zhao, James E. Rothman, Edward S. Allgeyer
Publikováno v:
Nature Methods
Nature methods, vol 18, iss 6
Nature methods
Nature methods, vol 18, iss 6
Nature methods
Understanding cellular organization demands the best possible spatial resolution in all three dimensions. In fluorescence microscopy, this is achieved by 4Pi nanoscopy methods that combine the concepts of using two opposing objectives for optimal dif
Autor:
Jacopo Antonello, Martin J. Booth, Lena K. Schroeder, Francesca Bottanelli, Joerg Bewersdorf, Xiang Hao, Phylicia Kidd, Edward S. Allgeyer, Lynn Cooley, Julianne A. Gerdes, Thomas Biederer, Jiaxi Zhao, James E. Rothman, Katherine Watters, Mark D. Lessard
Understanding cellular organization demands the best possible spatial resolution in all three dimensions (3D). In fluorescence microscopy, this is achieved by 4Pi nanoscopy methods that combine the concepts of using two opposing objectives for optima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec245cdcac6500073e46bfcae924f5c
https://doi.org/10.1101/2020.11.25.398958
https://doi.org/10.1101/2020.11.25.398958
Autor:
Giulia Biancon, Poorval Joshi, Joshua T Zimmer, Torben Hunck, Yimeng Gao, Mark D Lessard, Edward Courchaine, Andrew ES Barentine, Martin Machyna, Valentina Botti, Ashley Qin, Rana Gbyli, Amisha Patel, Yuanbin Song, Lea Kiefer, Gabriella Viero, Nils Neuenkirchen, Haifan Lin, Joerg Bewersdorf, Matthew D Simon, Karla M Neugebauer, Toma Tebaldi, Stephanie Halene
Publikováno v:
Blood. 138:321-321
Somatic mutations in splicing factor genes are drivers of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The splicing factors U2AF1 and U2AF2 form the U2AF heterodimer that is critical in the 3' splice site (3'SS) recognition and i
Autor:
Yuanbin Song, James E. Rothman, Pietro De Camilli, Lena K. Schroeder, David Baddeley, Mark D. Lessard, Phylicia Kidd, Lorena Benedetti, Jonas Ries, Jeeyun Chung, Joerg Bewersdorf, Yongdeng Zhang, Yiming Li
Combining the molecular specificity of fluorescent probes with three-dimensional (3D) imaging at nanoscale resolution is critical for investigating the spatial organization and interactions of cellular organelles and protein complexes. We present a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c577c97ba061563006ef45cf4115f918
https://doi.org/10.1101/613174
https://doi.org/10.1101/613174
Autor:
Lydie Plecitá-Hlavatá, Lukáš Alán, Andrea Dlasková, Jitka Špačková, Vendula Stradalova, Jan Tauber, Petr Ježek, Joerg Bewersdorf, Jan Malínský, Tomáš Špaček, Mark D. Lessard, Hana Engstová, Katarína Smolková
Publikováno v:
The FASEB Journal. 30:1941-1957
The relationship of the inner mitochondrial membrane (IMM) cristae structure and intracristal space (ICS) to oxidative phosphorylation (oxphos) is not well understood. Mitofilin (subunit Mic60) of the mitochondrial contact site and cristae organizing
Autor:
Mark D. Lessard, Yongdeng Zhang, Apostolos A. Karanastasis, Joerg Bewersdorf, Chaitanya K. Ullal, Gopal S. Kenath
Publikováno v:
Materials Horizons
The majority of gels exhibit nanoscale spatial variations in crosslink density. We present the first 3D super-resolution microscopy images of dye tagged cross-link distributions in microgels and hydrogels. The morphology of nanoscale features never i