Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark D. Lanigan"'
Publikováno v:
Biochemistry. 40:15528-15537
ShK toxin, a potassium channel blocker from the sea anemone Stichodactyla helianthus, is a 35-residue polypeptide cross-linked by 3 disulfide bridges. In an effort to generate truncated peptidic analogues of this potent channel blocker, we have evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a3567521b77b822b57e3025e384413
https://doi.org/10.1021/bi011300b
https://doi.org/10.1021/bi011300b
Publikováno v:
Biopolymers. 58:422-436
ShK toxin, a 35-residue polypeptide cross-linked by three disulfides, is a potent blocker of voltage-gated potassium channels and is of interest as a lead in the development of new immunosuppressant agents. ShK toxin contains two short stretches of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663aba75e1b0e514612d1d8bd0ae79ed
https://doi.org/10.1002/1097-0282(20010405)58:4<422::aid-bip1018>3.0.co
https://doi.org/10.1002/1097-0282(20010405)58:4<422::aid-bip1018>3.0.co
Autor:
Michael D. Cahalan, Michael W. Pennington, Heiko Rauer, K. George Chandy, Mark D. Lanigan, Raymond S. Norton, Sanjiv Ghanshani, Jayashree Aiyar
Publikováno v:
Journal of Biological Chemistry. 275:1201-1208
We have used a structure-based design strategy to transform the polypeptide toxin charybdotoxin, which blocks several voltage-gated and Ca(2+)-activated K(+) channels, into a selective inhibitor. As a model system, we chose two channels in T-lymphocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d478fd0cb9b9634e87531996a53fff5
https://doi.org/10.1074/jbc.275.2.1201
https://doi.org/10.1074/jbc.275.2.1201
Autor:
Heiko Rauer, K. Kalman, Kathy Paschetto, Angela Nguyen, Edward P. Christian, Michael D. Cahalan, George A. Gutman, William R. Kem, Raymond S. Norton, Michael W. Pennington, V.M. Mahnir, K. George Chandy, Mark D. Lanigan, Stephan Grissmer
Publikováno v:
Journal of Biological Chemistry. 273:32697-32707
The voltage-gated potassium channel in T lymphocytes, Kv1.3, is an important molecular target for immunosuppressive agents. A structurally defined polypeptide, ShK, from the sea anemone Stichodactyla helianthus inhibited Kv1.3 potently and also block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b612592cdc394456df7f7fedca46b
https://doi.org/10.1074/jbc.273.49.32697
https://doi.org/10.1074/jbc.273.49.32697
Autor:
Denise Donaldson, Raymond S. Norton, Kati Kalman, Mark D. Lanigan, William R. Kem, V.M. Mahnir, K. George Chandy, Cheryl T. McVaugh, Michael W. Pennington, David Behm
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Michael W. Pennington, Mark Lanigan, Vladimir M. Mahnir, Kati Kalman, Cheryl T. McVaugh, David Behm, Denise Donaldson, K. George Chandy, William R. Kem, and Raymond S. Norton2 Bachem Bioscience Inc., King of Prussia, PA 19406, U.S.A.; Biomolecular Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e315390ff8cbd893dc3c74e9e0e1174
https://doi.org/10.1007/0-306-46881-6_304
https://doi.org/10.1007/0-306-46881-6_304
Autor:
Mark D. Lanigan, Raymond S. Norton, K. Kalman, K. George Chandy, Michael W. Pennington, Yann Lefievre
Publikováno v:
Biochemistry. 41(40)
The voltage-gated potassium channel in T lymphocytes, Kv1.3, an important target for immunosuppressants, is blocked by picomolar concentrations of the polypeptide ShK toxin and its analogue ShK-Dap22. ShK-Dap22 shows increased selectivity for Kv1.3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba20ea113dc132f7847fb0a9b25a90a
https://pubmed.ncbi.nlm.nih.gov/12356296
https://pubmed.ncbi.nlm.nih.gov/12356296
Publikováno v:
Proteomics; Apr2004, Vol. 4 Issue 4, p1094-1100, 7p