Výsledky vyhledávání - "Mark D. Hicar"

Akademický článek

Seasonal Testing, Results, and Effect of the Pandemic on Coxsackievirus Serum Studies

Autor: Ramesh Kordi, Arthur J. Chang, Mark D. Hicar

Publikováno v: Microorganisms, Vol 12, Iss 2, p 367 (2024)

Coxsackieviruses (CVs) are common causes of infections and can be life-threatening. Unfortunately, rigorous studies guiding the clinician in interpreting CV serum antibody titer testing is lacking. To explore the epidemiology of circulating CVs and t

Externí odkaz: https://doaj.org/article/c44ee4b66c5e4e0ea6909af0bc64699c

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Akademický článek

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1

Autor: Grant Klug, Frances M. Cole, Mark D. Hicar, Connie Watt, Tami Peters, Seth H. Pincus

Publikováno v: Vaccines, Vol 11, Iss 4, p 829 (2023)

We are developing cytotoxic immunoconjugates (CICs) targeting the envelope protein (Env) of the Human Immunodeficiency Virus, type 1 (HIV) to purge the persistent reservoirs of viral infection. We have previously studied the ability of multiple monoc

Externí odkaz: https://doaj.org/article/fa48a71784544d62adac48bf26e89b67

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Akademický článek

Robust humoral immune response after boosting in children with Multisystem Inflammatory Syndrome in Children

Autor: Arthur J. Chang, Sarah Baron, Mark D. Hicar

Publikováno v: IDCases, Vol 29, Iss , Pp e01569- (2022)

The exact pathogenesis of Multisystem Inflammatory Syndrome in Children (MIS-C) is unknown. Reports on response to vaccination in children who had MIS-C are lacking. Using prospectively enrolled children, we report on humoral immune responses prior t

Externí odkaz: https://doaj.org/article/d05e4fb1145a46ae80e61407b18cd1e6

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Akademický článek

Decreased Clinical Severity of Pediatric Acute COVID-19 and MIS-C and Increase of Incidental Cases during the Omicron Wave in Comparison to the Delta Wave

Autor: Patrick O. Kenney, Arthur J. Chang, Lorna Krabill, Mark D. Hicar

Publikováno v: Viruses, Vol 15, Iss 1, p 180 (2023)

This study describes differences in clinical presentation in hospitalized children with acute COVID-19 and MIS-C between the Delta and Omicron (BA.1.1) waves in a tertiary children’s hospital. This retrospective cohort study with case adjudication

Externí odkaz: https://doaj.org/article/c767068ae8a340bbae15af624316c6b4

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Akademický článek

B Cells and Antibodies in Kawasaki Disease

Autor: Michael E. Lindquist, Mark D. Hicar

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 8, p 1834 (2019)

The etiology of Kawasaki disease (KD), the leading cause of acquired heart disease in children, is currently unknown. Epidemiology supports a relationship of KD to an infectious disease. Several pathological mechanisms are being considered, including

Externí odkaz: https://doaj.org/article/d77cb41a78304267876329e1c6cfb83d

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Upregulation of type 1 conventional dendritic cells implicates antigen cross-presentation in multisystem inflammatory syndrome

Autor: Robert Winchester, Alexis Boneparth, Mark Gorelik, Samantha B. Gaines, Peter S. Dayan, Mateo L. Amezcua, Janice J. Huang, Tamar R. Lubell, Marissa Dale, Mark D. Hicar

Publikováno v: The Journal of Allergy and Clinical Immunology

Background Multisystem inflammatory syndrome in children (MIS-C) is an acute, febrile, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated syndrome, often with cardiohemodynamic dysfunction. Insight into mechanism of disease is st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af006b9289f4e815206538a729abacc2
https://doi.org/10.1016/j.jaci.2021.10.015

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503. Lack of coronary aneurysms during Kawasaki Disease (KD) correlates with higher levels of autoantibodies to both full form and spliced variant of immune regulator EDIL-3 (Del-1)

Autor: R Ross Welliver, Aviraag Vijaya Prakash, Mark D Hicar

Publikováno v: Open Forum Infectious Diseases. 9

Background Kawasaki disease is a rare multisystem inflammatory condition that mainly affects children under the age of 5 years. Current theory of the pathogenesis is that an infectious stimulus triggers an autoimmune reaction in a genetically suscept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e0ae00a9a73e5b71d53d8961e6a290b
https://doi.org/10.1093/ofid/ofac492.559

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493. Defining background shared antibody sequences between unrelated healthy individuals (public clonotypes) to support future studies on specific infectious disease related conditions

Autor: Arthur Chang, Mark D Hicar

Publikováno v: Open Forum Infectious Diseases. 9

Background Public clonotypes, antibodies against specific antigens in unrelated individuals that have genetic similarities, have been shown in a variety of infections, including SARS-CoV-2 and HIV. Likely, there are shared antibody responses between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49f3c4c20e55b4a3ac75fa522394db15
https://doi.org/10.1093/ofid/ofac492.551

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