Výsledky vyhledávání - "Mark D. Brennan"

Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group

Autor: Qian Liu, Timothy Lynn Ramsey, Mark D. Brennan

Publikováno v: Pharmacogenomics. 15:933-939

Aim: Antipsychotic efficacy biomarkers have the potential to improve outcomes in psychotic patients. This study examined the effect of SULT4A1-1 haplotype status (rs2285162 [A]-rs2285167 [G]) on olanzapine response. Patients & methods: We evaluated 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4317a3a953348d0f112d11dc75b1519a
https://doi.org/10.2217/pgs.14.54

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Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE Study

Autor: Bill W. Massey, Qian Liu, Timothy Lynn Ramsey, Mark D. Brennan

Publikováno v: Schizophrenia Research. 149:21-25

Pharmacogenetic (PGx) predictors of response would improve outcomes in antipsychotic treatment. Based on both biological rationale and prior evidence of an impact on Parkinson's disease, we conducted an association study for 106 SNPs in the synaptic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad215939dcb9a41eccb85813ec09f003
https://doi.org/10.1016/j.schres.2013.07.008

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Glucagon-like Peptide 1 Receptor (GLP1R) Genetic Variants Impact Response to Olanzapine and Risperidone in Multiple Cohorts Across Two Independent Studies

Autor: Mark D. Brennan, Timothy Lynn Ramsey

Publikováno v: Dual Diagnosis: Open Access. 1

Background: Pharmacogenetic markers of antipsychotic response have the potential to reduce trial and error prescribing, leading to better outcomes. GLP1R genetic variation has previously shown PGx potential. This study was intended to identify testab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b748b6ff2e5e234abd6580937ce2a88
https://doi.org/10.21767/2472-5048.100022

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Use of Pharmacogenetic Testing in Routine Clinical Practice Improves Outcomes for Psychiatry Patients

Autor: eep Vaishnavi, Qian Liu, Timothy Lynn Ramsey, Elizabeth Griffin, Mark D. Brennan

Publikováno v: Journal of Psychiatry. 19

Introduction: In clinical trials, pharmacogenetic testing has been shown to improve outcomes in psychiatric patients. It is unclear if these improved outcomes translate into routine clinical practice. A significant impediment to evaluation of pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3aede72edda1144e57930ed85f09f490
https://doi.org/10.4172/2378-5756.1000377

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Targeted pharmacogenetic analysis of antipsychotic response in the CATIE study

Autor: Saranya Padmanabhan, Calvin Patrick, Maidar Jamba, Qian Liu, Mark D. Brennan

Publikováno v: Pharmacogenomics. 13:1227-1237

Aim: This study evaluated the impact of 6789 SNPs on treatment response to antipsychotics in Caucasian patients from the CATIE study.Materials & methods: An Illumina (CA, USA) BeadChip was designed that targeted genes potentially impacting disease ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe8a7b86e6f618b2fd4656d37936ae9
https://doi.org/10.2217/pgs.12.105

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A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene

Autor: Ted Kalbfleisch, Mark D. Brennan, Yanglong Zhu, Yong Li

Publikováno v: Schizophrenia Research. 109:86-89

Schizophrenia (SZ) is a neuropsychiatric disorder that affects about 1% of the adult population. Numerous genes have been implicated in SZ susceptibility. MicroRNAs (miRNA) are small RNA molecules that regulate the translation of mRNAs via interactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c759ff9232def621b2727dd39f4f1824
https://doi.org/10.1016/j.schres.2009.01.022

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MUC1 and estrogen receptor α gene polymorphisms in dry eye patients

Autor: Yoannis Imbert, William W. Young, Farzan Pouranfar, George John, Gary N. Foulks, Marcia M. Jumblatt, Catherine Newton, Hassan A. Shah, Mark D. Brennan

Publikováno v: Experimental Eye Research. 88:334-338

Dry eye syndrome is a collection of common disorders of multifactorial etiology. Although the epidemiology of dry eye has been well studied, reports of genetic patterns that might influence susceptibility to dry eye are few. We reported that the freq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155c69ccce731caf2f554466e8a6d3f8
https://doi.org/10.1016/j.exer.2008.05.019

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Glucagon-like peptide 1 receptor (GLP1R) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial

Autor: Mark D. Brennan, Timothy Lynn Ramsey

Publikováno v: Schizophrenia research. 160(1-3)

Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Previous work has shown that two coding mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d439bb4b75007ce1527ddfbca721ccd
https://pubmed.ncbi.nlm.nih.gov/25449714

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Pharmacogenetics of second-generation antipsychotics

Autor: Mark D. Brennan

Publikováno v: Pharmacogenomics. 15(6)

This review considers pharmacogenetics of the so called ‘second-generation’ antipsychotics. Findings for polymorphisms replicating in more than one study are emphasized and compared and contrasted with larger-scale candidate gene studies and geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785741340ae053145f6126e7336d52f5
https://pubmed.ncbi.nlm.nih.gov/24897292

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