Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Mark D Wewers"'
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209931 (2018)
Although the study of pathogen sensing by host defense systems continues to uncover a role for inflammasome components specific to particular pathogens, gaps remain in our knowledge. After internalization, Francisella escapes from the phagosome in mo
Externí odkaz:
https://doaj.org/article/95332ef8f4ee4e68b0c8461efee747d2
Autor:
Dmitry Ratner, M Pontus A Orning, Megan K Proulx, Donghai Wang, Mikhail A Gavrilin, Mark D Wewers, Emad S Alnemri, Peter F Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D Goguen, Egil Lien
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006035 (2016)
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS co
Externí odkaz:
https://doaj.org/article/7e19901ed97f4246a3cd738ecfdae743
Autor:
Devki Patel, Joseph P. McElroy, Daniel Y. Weng, Kamel Sahar, Sarah A. Reisinger, Jo L. Freudenheim, Mark D. Wewers, Peter G. Shields, Min-Ae Song
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Lung cancer exhibits sex-biased molecular characteristics and epidemiological trends, suggesting a need for sex-specific approaches to understanding its etiology and treatment. DNA methylation alterations play critical roles in lung carcinog
Externí odkaz:
https://doaj.org/article/413d5151e0d44b7fb069738a4d0c5a80
Autor:
Kruthika Sundaram, Mohd Akhlakur Rahman, Srabani Mitra, Daren L Knoell, Shireen A Woodiga, Samantha J King, Mark D Wewers
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161931 (2016)
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription factor IκBζ, are associated with increased susceptibility to invasive pneumococcal diseas
Externí odkaz:
https://doaj.org/article/f03265839ec1421f8694acd531504b82
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142203 (2015)
Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear that in live cell models cas
Externí odkaz:
https://doaj.org/article/6d3c17544fc34975b0689d0d4f3b0bf6
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127278 (2015)
Inflammasome activation is a two-step process where step one, priming, prepares the inflammasome for its subsequent activation, by step two. Classically step one can be induced by LPS priming followed by step two, high dose ATP. Furthermore, when IL-
Externí odkaz:
https://doaj.org/article/016ff3916904495ca5b9347e2d87443b
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117330 (2015)
BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune modul
Externí odkaz:
https://doaj.org/article/66e8f5024e6b41ccae37a3ad8ff7287d
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145607 (2015)
Lung endothelial cell apoptosis and injury occurs throughout all stages of acute lung injury (ALI/ARDS) and impacts disease progression. Lung endothelial injury has traditionally been focused on the role of neutrophil trafficking to lung vascular int
Externí odkaz:
https://doaj.org/article/010795138ed6401fbcaabf20ab3ae1a4
Autor:
Devyn D Gilette, Heather M Curry, Thomas eCremer, David eRavneberg, Kavin eFatehchad, Prexy eShah, Mark D Wewers, Larry S Schlesinger, Jonathan P Butchar, Susheela eTridandapani, Mikhail A Gavrilin
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 4 (2014)
Francisella tularensis is a Gram-negative facultative bacterium that can cause the disease tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of Francisella is its ability to dampen or subvert the host immune respon
Externí odkaz:
https://doaj.org/article/133474663892466ba14265149ed9a3a8
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92731 (2014)
Lung epithelial cell death is critical to the lung injury that occurs in the acute respiratory distress syndrome. It is known that FasL plays a prominent role in this lung cell death pathway and may work in part through activation of the receptor int
Externí odkaz:
https://doaj.org/article/f5d5efe70bb846a3924d94162e7d1dea