Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mark D Ware"'
Publikováno v:
Human Mutation. 27:1024-1029
The 185delAG mutation (c.68_69delAG; ter39) in the BRCA1 gene is a founder Jewish Ashkenazi mutation that is carried by 1% of this population and has been identified in thousands of breast or ovarian cancer patients. We have previously described that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0900876d812533fe07b40b1e3e4c4d
https://doi.org/10.1002/humu.20384
https://doi.org/10.1002/humu.20384
Autor:
Mark D. Ware, D DeSilva, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sean V. Tavtigian, Sylvie Mazoyer
Publikováno v:
Oncogene. 25:323-328
BRCA2 (BReast CAncer susceptibility gene 2) germline mutation carriers are at increased risk for breast and ovarian cancers. Mutations occurring in the ovarian cancer cluster region (OCCR) are linked to higher ovarian cancer and/or lower breast cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59fadb36a70b77f8d43b55e16a64665
https://doi.org/10.1038/sj.onc.1209033
https://doi.org/10.1038/sj.onc.1209033
Autor:
Gerald Krystal, Jacqueline E Damen, Cheryl D Helgason, Michael Huber, Michael R Hughes, Janet Kalesnikoff, Vivian Lam, Patty Rosten, Mark D Ware, Sandie Yew, R.Keith Humphries
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 31:1007-1010
In 1996 three groups independently cloned a hemopoietic specific, src homology 2-containing inositol 5'-phosphatase which, based on its structure, was called SHIP. More recently, a second more widely expressed SHIP-like protein has been cloned and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29c6fb77afb1a50833f1f40d3eb7c43
https://doi.org/10.1016/s1357-2725(99)00072-2
https://doi.org/10.1016/s1357-2725(99)00072-2
Autor:
Cheryl D. Helgason, Ling Liu, Michael Huber, Mark D. Ware, Vincent Duronio, Gerald Krystal, Michael P. Scheid, Jacqueline E. Damen, R. Keith Humphries
Publikováno v:
Progress in Biophysics and Molecular Biology. 71:423-434
The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8835412be393df9af64e3061b93d8e20
https://doi.org/10.1016/s0079-6107(98)00049-2
https://doi.org/10.1016/s0079-6107(98)00049-2
Autor:
Jacqueline E. Damen, Ling Liu, Mark D. Ware, Marina Ermolaeva, Philip W. Majerus, Gerald Krystal
Publikováno v:
Blood. 92:1199-1205
The SH2-containing inositol phosphatase, SHIP, often appears as multiple bands in anti-SHIP immunoblots. To characterize these bands, antisera were generated against the N-terminal (anti-N), mid-region (anti-M), and C-terminal (anti-C) portions of SH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6030d7d8b7807ebf52b23bfe5cfff84
https://doi.org/10.1182/blood.v92.4.1199.416k16_1199_1205
https://doi.org/10.1182/blood.v92.4.1199.416k16_1199_1205
Publikováno v:
Journal of Biological Chemistry. 272:10998-11001
We recently purified and cloned a 145-kDa protein that becomes tyrosine phosphorylated and associated with Shc in response to multiple cytokines. Based on its predicated amino acid sequence and its enzymatic activity, we have called this protein SHIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad9550645ad9670ee9778257b7d7162
https://doi.org/10.1074/jbc.272.17.10998
https://doi.org/10.1074/jbc.272.17.10998
Autor:
Olga Anczuków, Olga M. Sinilnikova, Monique Buisson, Almoutassem B. Zetoune, Sylvie Mazoyer, Mark D. Ware, Dominique Stoppa-Lyonnet
Publikováno v:
Human mutation. 29(1)
The nonsense-mediated mRNA decay (NMD) mechanism is an evolutionarily conserved process ensuring the degradation of transcripts carrying premature termination codon(s). NMD is believed to prevent the synthesis of truncated proteins that could be detr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d01321d3b074ebf44051b62a9560f53
https://pubmed.ncbi.nlm.nih.gov/17694537
https://pubmed.ncbi.nlm.nih.gov/17694537
Publikováno v:
Blood. 97(5)
The SH2-containing inositol-5'-phosphatase, SHIP, restrains bone marrow-derived mast cell (BMMC) degranulation, at least in part, by hydrolyzing phosphatidylinositol (PI)-3-kinase generated PI-3,4,5-P(3) (PIP3) to PI-3,4-P(2). To determine which doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae66401221203173064e11ede66411a1
https://pubmed.ncbi.nlm.nih.gov/11222379
https://pubmed.ncbi.nlm.nih.gov/11222379
Publikováno v:
Experimental Hematology. 28:84-85
We recently reported that the src homology 2 (SH2)-containing inositol 5-phosphatase, SHIP, acts as a gatekeeper of bone marrow derived mast cell (BMMC) degranulation by preventing inappropriate and excess release of inflammatory mediators (PNAS 95,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf2b9dbf2b849d1e57224d8be2c6ae9
https://doi.org/10.1016/s0301-472x(00)00351-9
https://doi.org/10.1016/s0301-472x(00)00351-9