Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Mark D Scott"'
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145179 (2015)
Autoimmune destruction of the pancreatic islets in Type 1 diabetes is mediated by both increased proinflammatory (Teff) and decreased regulatory (Treg) T lymphocytes resulting in a significant decrease in the Treg:Teff ratio. The non-obese diabetic (
Externí odkaz:
https://doaj.org/article/40bd2b0b85e74a0499aa76bc946e3f70
Autor:
Emel Islamzada, Kerryn Matthews, Erik S. Lamoureux, Simon P. Duffy, Mark D. Scott, Hongshen Ma
Publikováno v:
eJHaem, Vol 3, Iss 1, Pp 63-71 (2022)
Abstract Red blood cells (RBCs) stored in blood bags develop a storage lesion that include structural, metabolic, and morphologic transformations resulting in a progressive loss of RBC deformability. The speed of RBC deformability loss is donor‐dep
Externí odkaz:
https://doaj.org/article/c1fbf559b5254b52af005f727e13212f
Autor:
Quan Guo, Emel Islamzada, Mark D. Scott, Aline T. Santoso, Hongshen Ma, Kerryn Matthews, Simon P. Duffy
Publikováno v:
Lab on a Chip. 20:226-235
A fundamental challenge in the transfusion of red blood cells (RBCs) is that a subset of donated RBC units may not provide optimal benefit to transfusion recipients. This variability stems from the inherent ability of donor RBCs to withstand the phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ecd254c9186d1b13becd80966cafa4
https://doi.org/10.1039/c9lc01058k
https://doi.org/10.1039/c9lc01058k
Publikováno v:
TransfusionREFERENCES. 62(2)
The biophysical properties of red blood cells (RBCs) provide potential biomarkers for the quality of donated blood. Blood unit segments provide a simple and nondestructive way to sample RBCs in clinical studies of transfusion efficacy, but it is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3f52a720c3f40c4b5d296ef22ff851
https://pubmed.ncbi.nlm.nih.gov/34877683
https://pubmed.ncbi.nlm.nih.gov/34877683
BACKGROUNDThe biophysical properties of red blood cells (RBCs) provide potential biomarkers for the quality of donated blood. Blood unit segments provide a simple and nondestructive way to sample RBCs in clinical studies of transfusion efficacy, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db92afd6115c37240c50a512f5f2678
https://doi.org/10.1101/2021.07.20.453156
https://doi.org/10.1101/2021.07.20.453156
RBC transfusions are a life-saving procedure, aiding both chronic and acute patients in restoring tissue oxygenation. The ability to store collected RBC units for prolonged periods has been one of the most transformative advances in medicine, signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76478c28a291f792aac55af64c2baa91
https://doi.org/10.1101/2021.07.20.452409
https://doi.org/10.1101/2021.07.20.452409
Autor:
Emel Islamzada, Kerryn Matthews, Erik S. Lamoureux, Simon P. Duffy, Mark D. Scott, Hongshen Ma
Publikováno v:
EJHaem. 3(1)
Red blood cells (RBCs) stored in blood bags develop a storage lesion that include structural, metabolic, and morphologic transformations resulting in a progressive loss of RBC deformability. The speed of RBC deformability loss is donor-dependent, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1f445fb7962472be9c2d5afa582a3b
https://pubmed.ncbi.nlm.nih.gov/35846223
https://pubmed.ncbi.nlm.nih.gov/35846223
Publikováno v:
Immunobiology. 224:270-284
T lymphocytes play a critical role in the pro-inflammatory anti-cancer response; hence, significant pharmacologic efforts have been made to enhance the endogenous T cell response. Unfortunately, significant toxicity arises consequent to pan T cell ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba6c00e2cffd32a689ec4c66dd9d93d
https://doi.org/10.1016/j.imbio.2018.12.003
https://doi.org/10.1016/j.imbio.2018.12.003
Publikováno v:
Archivum Immunologiae et Therapiae Experimentalis
Effective immunomodulation of T-cell responses is critical in treating both autoimmune diseases and cancer. Our previous studies have demonstrated that secretomes derived from control or methoxypolyethylene glycol mixed lymphocyte alloactivation assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f27ca8f4c20bb60b9f8c9bd18be1d4
https://pubmed.ncbi.nlm.nih.gov/34677693
https://pubmed.ncbi.nlm.nih.gov/34677693
Autor:
Xining Yang, Mark D. Scott
T cell-mediated immunomodulation can be, in simple terms, defined as altering the normal Treg:Teff ratio. Immunosuppression skews the net Treg:Teff ratio toward the ‘tolerogenic’ Treg component, while immunoactivation skews the response toward th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4484c62f3ce78f8036b4f3fa11e8e54
https://doi.org/10.5772/intechopen.92038
https://doi.org/10.5772/intechopen.92038