Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark D M, Leiserson"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011195 (2023)
Mutational processes and their exposures in particular genomes are key to our understanding of how these genomes are shaped. However, current analyses assume that these processes are uniformly active across the genome without accounting for potential
Externí odkaz:
https://doaj.org/article/5559e5019ac74465b4dfb1ba35e822c6
Autor:
Sanju Sinha, Karina Barbosa, Kuoyuan Cheng, Mark D. M. Leiserson, Prashant Jain, Anagha Deshpande, David M. Wilson, Bríd M. Ryan, Ji Luo, Ze’ev A. Ronai, Joo Sang Lee, Aniruddha J. Deshpande, Eytan Ruppin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may co
Externí odkaz:
https://doaj.org/article/5fe16eb955dc4e7db09618e84c592388
Autor:
Yoo-Ah Kim, Damian Wojtowicz, Rebecca Sarto Basso, Itay Sason, Welles Robinson, Dorit S. Hochbaum, Mark D. M. Leiserson, Roded Sharan, Fabio Vadin, Teresa M. Przytycka
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting fr
Externí odkaz:
https://doaj.org/article/f01e56dc07e744279a4dd467a1377f16
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009542 (2021)
Mutational processes shape the genomes of cancer patients and their understanding has important applications in diagnosis and treatment. Current modeling of mutational processes by identifying their characteristic signatures views each base substitut
Externí odkaz:
https://doaj.org/article/2e2db682464b4c72ad2e2f5eb12868df
Autor:
Damian Wojtowicz, Itay Sason, Xiaoqing Huang, Yoo-Ah Kim, Mark D. M. Leiserson, Teresa M. Przytycka, Roded Sharan
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Knowing the activity of the mutational processes shaping a cancer genome may provide insight into tumorigenesis and personalized therapy. It is thus important to characterize the signatures of active mutational processes in patients from the
Externí odkaz:
https://doaj.org/article/52d581e81ff7471e8af71d9aaad35546
Autor:
Sanju Sinha, Karina Barbosa, Kuoyuan Cheng, Mark D. M. Leiserson, Prashant Jain, Anagha Deshpande, David M. Wilson, Bríd M. Ryan, Ji Luo, Ze’ev A. Ronai, Joo Sang Lee, Aniruddha J. Deshpande, Eytan Ruppin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/e04907597a04403a89db5ed3748c7c23
Publikováno v:
Cancers
Volume 15
Issue 5
Pages: 1601
Volume 15
Issue 5
Pages: 1601
Mutational signature analysis promises to reveal the processes that shape cancer genomes for applications in diagnosis and therapy. However, most current methods are geared toward rich mutation data that has been extracted from whole-genome or whole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f539ca1ff4c141923dc9374e599394
Autor:
Mark D M Leiserson, Vasilis Syrgkanis, Amy Gilson, Miroslav Dudik, Sharon Gillett, Jennifer Chayes, Christian Borgs, Dean F Bajorin, Jonathan E Rosenberg, Samuel Funt, Alexandra Snyder, Lester Mackey
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208422 (2018)
Checkpoint inhibitor immunotherapies have had major success in treating patients with late-stage cancers, yet the minority of patients benefit. Mutation load and PD-L1 staining are leading biomarkers associated with response, but each is an imperfect
Externí odkaz:
https://doaj.org/article/e6fce04c3eed4a8d9062a93993da9afa
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003054 (2013)
Distinguishing the somatic mutations responsible for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomics. Driver mutations generally target cellular signaling and regulatory pathways consisting of multiple
Externí odkaz:
https://doaj.org/article/18f6e798e1c848eeb0f54886920e4b89
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 25
Distinct mutational processes shape the genomes of the clones comprising a tumor. These processes result in distinct mutational patterns, summarized by a small number of mutational signatures. Current analyses of clone-specific exposures to mutationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9787dd2f364222bdd5b3b5b852ebfc0
https://pubmed.ncbi.nlm.nih.gov/31797599
https://pubmed.ncbi.nlm.nih.gov/31797599