Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mark D McKenzie"'
Autor:
Steven Ngo, Ethan P. Oxley, Margherita Ghisi, Maximilian M. Garwood, Mark D. McKenzie, Helen L. Mitchell, Peter Kanellakis, Olivia Susanto, Michael J. Hickey, Andrew C. Perkins, Benjamin T. Kile, Ross A. Dickins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Differentiation therapy induces the maturation and clearance of acute myeloid leukemia cells. Here, using a mouse model, the authors show that a specific lineage of mature leukemia-derived cells persists during remission and is responsible for diseas
Externí odkaz:
https://doaj.org/article/5f04ec10aa484e7aa4589412ec95bdf7
Autor:
Matthew P. McCormack, Sara Tomei, Olivia Stonehouse, Adrienne A. Hilton, Matthew E. Ritchie, Andrew Jarratt, Dawn S. Lin, Warren S. Alexander, Samir Taoudi, Mark D. McKenzie, Stephen L. Nutt, Jaring Schreuder, Ashley P. Ng, Shalin H. Naik, Ladina Di Rago, Daniela Amann-Zalcenstein, Jacob T. Jackson, Jessica E. Bolden, Carolyn A. de Graaf, Kirsten A. Fairfax, Luyi Tian
Publikováno v:
Nature Immunology. 21:1574-1584
A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. Lin-c-Kit+Sca-1+Flt3+ cells, termed lymphoid-primed multipotent progenitors (LMPPs), have lost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4caa15b473124e6d02b7011f0da5dd7c
https://doi.org/10.1038/s41590-020-0799-x
https://doi.org/10.1038/s41590-020-0799-x
Autor:
Ross A. Dickins, Benjamin T. Kile, Steven Ngo, Andrew C. Perkins, Mark D. McKenzie, Margherita Ghisi, Olivia Susanto, Michael J. Hickey, Helen Mitchell, Peter Kanellakis, Ethan P. Oxley, Maximilian M. Garwood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Acute myeloid leukemia (AML) is a malignancy of immature progenitor cells. AML differentiation therapies trigger leukemia maturation and can induce remission, but relapse is prevalent and its cellular origin is unclear. Here we describe high resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02bb601aeb847137df13cd466d6a013
https://doi.org/10.1038/s41467-021-26849-w
https://doi.org/10.1038/s41467-021-26849-w
Autor:
Natasha Silke, Manfred Boehm, Amanda K. Ombrello, Ivona Aksentijevich, Deborah L. Stone, Tina Romeo, Marco J Herold, Laurens Wachsmuth, Christine Biben, Beverly K. Barham, Lin Liu, Andrew J. Gross, Sergio D. Rosenzweig, Patrycja Hoffmann, Natalia Sampaio Moura, Gustavo Gutierrez-Cruz, Daniel L. Kastner, Steven E. Boyden, Kristien J. M. Zaal, Anne K. Voss, Holly Anderton, Anne Jones, Hongying Wang, Tobias Kratina, John Silke, Michael J. Lenardo, James C. Mullikin, Kate E. Lawlor, David B. Beck, Mark D. McKenzie, Amanda Light, Anthony K. Shum, Jae Jin Chae, Massimo Gadina, Qing Zhou, Diep Chau, Gineth Pinto-Patarroyo, Hirotsugu Oda, Geryl Wood, Mary Blake, Nima Etemadi, Kristy Shield-Artin, Edwin D. Hawkins, Monique Stoffels, Cathrine Hall, Dan Yang, Wanxia Li Tsai, Hye Sun Kuehn, Natalia I. Dmitrieva, Seth L. Masters, Lixin Zheng, Andrew J. Kueh, Manolis Pasparakis, Najoua Lalaoui
Publikováno v:
Nature
Nature, vol 577, iss 7788
Nature, vol 577, iss 7788
Receptor Interacting Protein Kinase 1 (RIPK1) is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is post-translationally regulated by well characterised ubiquitylation and phosphorylation events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a3bb64e2ed7e5ed42a46b65bfc0fb6
https://doi.org/10.1038/s41586-019-1828-5
https://doi.org/10.1038/s41586-019-1828-5
Autor:
Matthew E. Ritchie, Kirsten A. Fairfax, Geyu Zhou, Mark D. McKenzie, Ladina Di Rago, Bruce S. Bochner, Erin C. Lucas, Carolyn A. de Graaf, Douglas J. Hilton, Warren S. Alexander, Tracey M. Baldwin, Jessica E. Bolden, Jeremy A. O'Sullivan, Jake Shortt
Publikováno v:
Journal of leukocyte biology
In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2a1857ce85e95745215fa40c4805e0
https://doi.org/10.1002/jlb.1ma1217-475r
https://doi.org/10.1002/jlb.1ma1217-475r
Autor:
Tracy A. Willson, Cedric S. Tremblay, Margherita Ghisi, Mark D. McKenzie, Ioannis Aifantis, Grace Liu, Yifang Hu, Gordon K. Smyth, Ross A. Dickins, Kathryn G. Roberts, Seth Frietze, Oliver D. Le Grice, Martin A. Horstmann, Matthew T. Witkowski, Luisa Cimmino, Judith M. Boer, Charles G. Mullighan, Monique L. den Boer
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 214(3), 773-791. Rockefeller University Press
Journal of Experimental Medicine, 214(3), 773-791. Rockefeller University Press
Analysis of mouse and human B lineage acute lymphoblastic leukemia identifies evolutionarily conserved targets of the tumor-suppressive transcription factor IKAROS, implicating CTNND1 in leukemia maintenance.
Genetic alterations disrupting the t
Genetic alterations disrupting the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4a82a1ec2e2818c0a2557b82aad4bf
http://europepmc.org/articles/PMC5339666
http://europepmc.org/articles/PMC5339666
Autor:
Daniela, Amann-Zalcenstein, Luyi, Tian, Jaring, Schreuder, Sara, Tomei, Dawn S, Lin, Kirsten A, Fairfax, Jessica E, Bolden, Mark D, McKenzie, Andrew, Jarratt, Adrienne, Hilton, Jacob T, Jackson, Ladina, Di Rago, Matthew P, McCormack, Carolyn A, de Graaf, Olivia, Stonehouse, Samir, Taoudi, Warren S, Alexander, Stephen L, Nutt, Matthew E, Ritchie, Ashley P, Ng, Shalin H, Naik
Publikováno v:
Nature immunology. 21(12)
A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. Lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4907eb136484612c74aac4efa521bca
https://pubmed.ncbi.nlm.nih.gov/33077975
https://pubmed.ncbi.nlm.nih.gov/33077975
Autor:
Mark D. McKenzie, Jaring Schreuder, Kirsten A. Fairfax, Andrew Jarrat, Jess Bolden, Matt McCormack, Sara Tomei, Matthew E. Ritchie, Ladina Di Rago, Adrienne A. Hilton, Daniela Zalcenstein, Jacob T. Jackson, Ashley P. Ng, Dawn S. Y. Lin, Warren S. Alexander, Shalin H. Naik, Luyi Tian, D J Hilton
Publikováno v:
Experimental Hematology. 76:e1-e2
A classical view of blood cell development is that multipotent haematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. The Lin–c-kit+Sca1+Flt3+ stage, termed lymphoid-primed multipotent progenitors (LMPPs), hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bcf31e9ae64c8cddda9f359c06cc80
https://doi.org/10.1016/j.exphem.2019.09.006
https://doi.org/10.1016/j.exphem.2019.09.006
Autor:
S. Jayakrishnan, Benjamin T. Kile, Michael J. Hickey, Maximilian M. Garwood, Olivia Susanto, S. Ngo, Andrew C. Perkins, Mark D. McKenzie, Ross A. Dickins, Margherita Ghisi, Ethan P. Oxley, Helen Mitchell
Publikováno v:
HemaSphere. 3:53-54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12658d2024ee82869abe8a481fa708df
https://doi.org/10.1097/01.hs9.0000559024.54436.9a
https://doi.org/10.1097/01.hs9.0000559024.54436.9a
Autor:
Tracy A. Willson, Meinrad Busslinger, Yifang Hu, Thomas Trimarchi, Sarah A. Best, Matthew T. Witkowski, Luisa Cimmino, Stewart L Nutt, Ioannis Aifantis, Laura Tuohey, Hiromi Tagoh, Gordon K. Smyth, Ross A. Dickins, Mark D. McKenzie
Publikováno v:
Leukemia. 29:1301-1311
Activating NOTCH1 mutations occur in ~ 60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory interplay between these driver ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5141e234d7f27f248dff8c4dc2a4f6
https://doi.org/10.1038/leu.2015.27
https://doi.org/10.1038/leu.2015.27