Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Mark D, Hulett"'
Autor:
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-12 (2024)
Abstract Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious d
Externí odkaz:
https://doaj.org/article/62a57fe64f944d87ab3862e5bd598553
Autor:
Joanne L Kemp, Adam G Culvenor, Andrea B Mosler, Hayden G Morris, Peter Brukner, Lynette Law, Joshua L Heerey, Brooke L Devlin, Amanda Attanayake, Mark D Hulett, Alysha De Livera, Nathan P White
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Chronic inflammation plays a key role in knee osteoarthritis pathophysiology and increases risk of comorbidities, yet most interventions do not typically target inflammation. Our study will investigate if an anti-inflammatory dietary pro
Externí odkaz:
https://doaj.org/article/d55a3455ce2c4d1ca59f12b6d6bbc243
Autor:
Emily R. R. Mackie, Andrew S. Barrow, Marie-Claire Giel, Mark D. Hulett, Anthony R. Gendall, Santosh Panjikar, Tatiana P. Soares da Costa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide-resistant weeds. Here, we employed a novel strategy to re
Externí odkaz:
https://doaj.org/article/eceeb3445de3486eb8e9a93af8083536
Autor:
Scott A. Williams, Fung T. Lay, Guneet K. Bindra, Suresh Banjara, Ivan K. H. Poon, Thanh Kha Phan, Marc Kvansakul, Mark D. Hulett
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Defensins are a class of host defence peptides that contribute to the immune system of eukaryotes. Here, the authors report the structure of saltwater crocodile defensin CpoBD13 and the mechanism of pH-dependent antifungal activity.
Externí odkaz:
https://doaj.org/article/34709b6a3e3f4e138fbe3e5c970854e2
Autor:
Zoe I. Day, Alyce J. Mayfosh, Amy A. Baxter, Scott A. Williams, Joanne M. Hildebrand, Thomas F. Rau, Ivan K. H. Poon, Mark D. Hulett
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 555 (2024)
Here, we describe GS-9, a novel water-soluble fatty acid-based formulation comprising L-lysine and arachidonic acid, that we have shown to induce ferroptosis. GS-9 forms vesicle-like structures in solution and mediates lipid peroxidation, as evidence
Externí odkaz:
https://doaj.org/article/7ae74655cf7a41208939f28a5aa2a6ea
Autor:
Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman, Nicholas P. Reynolds
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Here the authors report the formation of toxic clumps of protein, similar to amyloid assemblies found in Alzheimer’s disease and suggest their possible role for some of the neurological symptoms of long-COVID.
Externí odkaz:
https://doaj.org/article/31ac39f0f9b2477098afc51ae04937ba
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-25 (2020)
Abstract Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to hep
Externí odkaz:
https://doaj.org/article/40c9c074652d4073a0d58c5948501b73
Autor:
Tien K. Nguyen, Stephanie Paone, Enoch Chan, Ivan K. H. Poon, Amy A. Baxter, Shane R. Thomas, Mark D. Hulett
Publikováno v:
Cells, Vol 11, Iss 20, p 3198 (2022)
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and its management places a huge burden on healthcare systems through hospitalisation and treatment. Atherosclerosis is a chronic inflammatory disease of the arteria
Externí odkaz:
https://doaj.org/article/46bfd90df202454d8a17f3786326abb2
Autor:
Alyce J. Mayfosh, Zoe I. Day, Nathan B. Unsworth, Chun-Qiang Liu, Ruchi Gupta, Soraya Haynes, Rebecca Abraham, Sam Abraham, Zo L. Shaw, Sumeet Walia, Aaron Elbourne, Mark D. Hulett, Thomas F. Rau
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1293 (2022)
The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scien
Externí odkaz:
https://doaj.org/article/dd3f8d3a87cf4675902a2eb91ef28c37
Autor:
Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini
Publikováno v:
eLife, Vol 10 (2021)
Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide targe
Externí odkaz:
https://doaj.org/article/4a54238d54044027a2091d81d099209c