Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Mark Cockett"'
1
Akademický článek
Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study.
Autor: Ira Dicker, Sharon Zhang, Neelanjana Ray, Brett R Beno, Alicia Regueiro-Ren, Samit Joshi, Mark Cockett, Mark Krystal, Max Lataillade
Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0224076 (2019)
GSK3532795 (formerly BMS955176) is a second-generation maturation inhibitor (MI) that progressed through a Phase 2b study for treatment of HIV-1 infection. Resistance development to GSK3532795 was evaluated through in vitro methods and was correlated
Externí odkaz: https://doaj.org/article/3b995319e0514af1ae5adab6ab9b72a9
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2
Akademický článek
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
Autor: Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack, Tian Yuan, Hong Yang, Zheng Liu, Dieter Drexler, Alicia Regueiro-Ren, Nicholas A Meanwell, Mark Cockett, Mark Krystal, Max Lataillade, Ira B Dicker
Publikováno v: PLoS Pathogens, Vol 12, Iss 11, p e1005990 (2016)
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second g
Externí odkaz: https://doaj.org/article/a90b160f045e49bcad42a4f0b6eb0ad7
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3
Akademický článek
Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.
Autor: Nannan Zhou, Bo Ding, Michele Agler, Mark Cockett, Fiona McPhee
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0117357 (2015)
The p21-activated kinase 3 (PAK3) and the serum and glucocorticoid-induced kinase 2 (SGK2) have been previously proposed as essential kinases for human papillomavirus positive (HPV+) cervical cancer cell survival. This was established using a shRNA k
Externí odkaz: https://doaj.org/article/13cb8764b1024fbdbf130b1c69b45986
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4
Akademický článek
Chemical genetics reveals an RGS/G-protein role in the action of a compound.
Autor: Kevin Fitzgerald, Svetlana Tertyshnikova, Lisa Moore, Lynn Bjerke, Ben Burley, Jian Cao, Pamela Carroll, Robert Choy, Steve Doberstein, Yves Dubaquie, Yvonne Franke, Jenny Kopczynski, Hendrik Korswagen, Stanley R Krystek, Nicholas J Lodge, Ronald Plasterk, John Starrett, Terry Stouch, George Thalody, Honey Wayne, Alexander van der Linden, Yongmei Zhang, Stephen G Walker, Mark Cockett, Judi Wardwell-Swanson, Petra Ross-Macdonald, Rachel M Kindt
Publikováno v: PLoS Genetics, Vol 2, Iss 4, p e57 (2006)
We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of urinary incontinence were tested on the nematode Caenorhabditis elegans, and the resulting phen
Externí odkaz: https://doaj.org/article/1932641b9cd346b58d4f8941da49cf1f
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