Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark Cayabyab"'
Autor:
Angela Carville, Kevin R. Carlson, Birgit Korioth-Schmitz, Norman L. Letvin, Harikrishnan Balachandran, Barton F. Haynes, Mark Cayabyab, Yue Sun, Adam P. Buzby, William R. Jacobs, Ayako Miura
Publikováno v:
Journal of Virology. 83:5505-5513
While mycobacteria have been proposed as vaccine vectors because of their persistence and safety, little has been done systematically to optimize their immunogenicity in nonhuman primates. We successfully generated recombinant Mycobacterium bovis BCG
Autor:
Michael W. Panas, Avi-Hai Hovav, Christa E. Osuna, Norman L. Letvin, Patrick Autissier, Mark Cayabyab
Publikováno v:
Journal of Virology. 81:12793-12802
While recent studies have demonstrated that secondary CD8 + T cells develop into effector-memory cells, the impact of particular vaccine regimens on the elicitation of these cells remains poorly defined. In the present study we evaluated the effect o
Autor:
Michael W. Panas, Piya Sircar, Mark Cayabyab, Shaila Rahman, Geoffrey O. Gillard, Norman L. Letvin, Avi-Hai Hovav
Publikováno v:
The Journal of Immunology. 179:6725-6733
The duration of Ag expression in vivo has been reported to have a minimal impact on both the magnitude and kinetics of contraction of a pathogen-induced CD8+ T cell response. In this study, we controlled the duration of Ag expression by excising the
Publikováno v:
Journal of Virology. 81:10606-10613
While administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce the local recruitment of activated antigen-presenting cells at the site of vaccine inoculation, this cellular recruitment is associated with a paradoxical de
Autor:
Phillip Stashenko, Emily Xie, Margaret J. Duncan, Abhiroop Kotha, Mark Cayabyab, Nikita Sedani, Antonio Campos-Neto, Jonathan Zou, Tracy Biaco
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143422 (2015)
PLoS ONE
PLoS ONE
The pioneer human oral commensal bacterium Streptococcus mitis has unique biologic features that make it an attractive mucosal vaccine or therapeutic delivery vector. S. mitis is safe as a natural persistent colonizer of the mouth, throat and nasopha
Autor:
Mark Cayabyab, Herman F. Staats, Richard Frothingham, Tsungda Hsu, Stacie Vanleeuwen, Norman L. Letvin, James W. Peacock, Jae-Sung Yu, Hua-Xin Liao, William R. Jacobs, Barton F. Haynes
Publikováno v:
Clinical and Vaccine Immunology. 13:1204-1211
A successful vaccine vector for human immunodeficiency virus type 1 (HIV-1) should induce anti-HIV-1 immune responses at mucosal sites. We have generated recombinant Mycobacterium smegmatis vectors that express the HIV-1 group M consensus envelope pr
Autor:
Joseph Sodroski, Byeongwoon Song, Michael K. Axthelm, Ngoc Phan, Liping Wang, Mark Cayabyab, Norman L. Letvin
Publikováno v:
Virology. 322:168-181
Simian–human immunodeficiency virus (SHIV) chimerae, after in vivo passage in monkeys, can induce acquired immunodeficiency syndrome (AIDS)-like illness and death. A monkey infected with the molecularly cloned, pathogenic SHIV-HXBc2P 3.2 exhibited
Autor:
Jeanne E. Bell, Paul R Gorry, Kevin J. Kunstman, Steven M. Wolinsky, Geoffrey H. Holm, Joann M. Taylor, Hui Wang, Dana Gabuzda, Tom Morgan, John P. Moore, Andrew Mehle, Michael Farzan, Mark Cayabyab
Publikováno v:
Journal of Virology. 76:6277-6292
Most human immunodeficiency virus type 1 (HIV-1) viruses in the brain use CCR5 as the principal coreceptor for entry into a cell. However, additional phenotypic characteristics are necessary for HIV-1 neurotropism. Furthermore, neurotropic strains ar
Publikováno v:
Journal of Virology. 75:4208-4218
The simian-human immunodeficiency virus SHIV-HXBc2 contains the envelope glycoproteins of a laboratory-adapted, neutralization-sensitive human immunodeficiency virus type 1 variant, HXBc2. Serial in vivo passage of the nonpathogenic SHIV-HXBc2 genera
Autor:
Tsehaynesh Messele, Masaki Hosoya, Naoki Nishizawa, Osamu Nishimura, Shuji Hinuma, Joseph Sodroski, Shoji Fukusumi, Hyeryun Choe, Mark Cayabyab, Masahiko Fujino, Michael Farzan, Chieko Kitada, Jaap Goudsmit, Georgios Pollakis
Publikováno v:
Journal of virology, 74(24), 11972-11976. American Society for Microbiology
In addition to the CCR5 and CXCR4 chemokine receptors, a subset of primary human immunodeficiency virus type 1 (HIV-1) isolates can also use the seven-transmembrane-domain receptor APJ as a coreceptor. A previously identified ligand of APJ, apelin, s