Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mark Carty"'
Autor:
Mark Carty, Lee Zamparo, Merve Sahin, Alvaro González, Raphael Pelossof, Olivier Elemento, Christina S. Leslie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Genome-wide chromosome conformation capture has helped us identify features of genome topology influencing biology but requires careful statistical analysis. Here the authors present HiC-DC, a bioinformatics method that can detect statistically signi
Externí odkaz:
https://doaj.org/article/5d47fe47c7bf4ef0ad411c538d7ab7a4
Autor:
Eric Lefkofsky, Martin C. Stumpe, Ameen A. Salahudeen, Aly A. Khan, Talal Ahmed, Raphael Pelossof, Jonathan R. Dry, Mark Carty, Stephane Wenric
Reproducibility of results obtained using RNA data across labs remains a major hurdle in cancer research. Often, molecular predictors trained on one dataset cannot be applied to another due to differences in RNA library preparation and quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c8de4453465a9506548c79d5234ae6
https://doi.org/10.1101/2021.04.01.437893
https://doi.org/10.1101/2021.04.01.437893
Abstract 242: Transferring diagnostic and prognostic molecular models across technological platforms
Publikováno v:
Cancer Research. 81:242-242
The reproducibility of results obtained using RNA data across labs is a major hurdle in cancer research. Difference in library preparation methods and gene expression quantification platforms prevent the application of trained models to new data acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3ae0714675dcf8af30ebd1eafe47cd
https://doi.org/10.1158/1538-7445.am2021-242
https://doi.org/10.1158/1538-7445.am2021-242
Publikováno v:
Journal of Clinical Oncology. 38:e13507-e13507
e13507 Background: Recent advances in transcriptomics have resulted in the emergence of several publicly available breast cancer RNA-Seq datasets, such as TCGA, SCAN-B, and METABRIC. However, molecular predictors cannot be applied across datasets wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b3e9c1c1ba89470c374dc24eb74d067
https://doi.org/10.1200/jco.2020.38.15_suppl.e13507
https://doi.org/10.1200/jco.2020.38.15_suppl.e13507
Autor:
Raphael Pelossof, Christina S. Leslie, Alvaro J. González, Merve Sahin, Lee Zamparo, Mark Carty, Olivier Elemento
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Here we present HiC-DC, a principled method to estimate the statistical significance (P values) of chromatin interactions from Hi-C experiments. HiC-DC uses hurdle negative binomial regression account for systematic sources of variation in Hi-C read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b505caa70172bd6756c9f40d9461fe3d
http://europepmc.org/articles/PMC5442359
http://europepmc.org/articles/PMC5442359
Autor:
Mark Carty, Olivier Elemento
Publikováno v:
Methods in Molecular Biology ISBN: 9781493935765
Statistical Genomics
Statistical Genomics
The three dimensional (3D) architecture of chromosomes is not random but instead tightly organized due to chromatin folding and chromatin interactions between genomically distant loci. By bringing genomically distant functional elements such as enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e875010311ecc2123d35c6b1f0db8f
https://doi.org/10.1007/978-1-4939-3578-9_9
https://doi.org/10.1007/978-1-4939-3578-9_9
Autor:
Mark Carty, Philip White
Publikováno v:
The International Journal of Life Cycle Assessment. 15:994-1013
This paper explores a computational method to resolve some of the problems of external normalization in the life cycle impact assessment (LCIA) process of midpoint characterized impacts. Problems inherent to external normalization (per capita per yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4349d7e2b42b70c39a267e0012045411
https://doi.org/10.1007/s11367-010-0215-0
https://doi.org/10.1007/s11367-010-0215-0
Autor:
Richard A. Miller, Joseph Y. Shin, Christopher Y. Park, Safak Yalcin, Christina S. Leslie, Mark Carty
Publikováno v:
Blood. 124:602-602
Aging hematopoietic stem cells (HSCs) exhibit numerous functional alterations including reduced capacity for self-renewal, myeloid-biased differentiation, and reduced production of mature lymphocytes and red blood cells. Interventions such as calorie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96ec580958ab3d88453096c2f5e1d94
https://doi.org/10.1182/blood.v124.21.602.602
https://doi.org/10.1182/blood.v124.21.602.602
Autor:
Richard A. Miller, Christopher Y. Park, Mark Carty, Safak Yalcin, Joseph Y. Shin, Christina S. Leslie
Publikováno v:
Experimental Hematology. 42:S21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81b9be3ea9c829bfdd1c3258f59531f
https://doi.org/10.1016/j.exphem.2014.07.074
https://doi.org/10.1016/j.exphem.2014.07.074
Autor:
Osinski, Bolesław L., BenTaieb, Aïcha, Ho, Irvin, Jones, Ryan D., Joshi, Rohan P., Westley, Andrew, Carlson, Michael, Willis, Caleb, Schleicher, Luke, Mahon, Brett M., Stumpe, Martin C.
Publikováno v:
Modern Pathology; Dec2022, Vol. 35 Issue 12, p1791-1803, 13p