Výsledky vyhledávání - "Mark C. Leavitt"

Inhibition of CCR5-Dependent HIV-1 Infection by Hairpin Ribozyme Gene Therapy against CC-Chemokine Receptor 5

Autor: David Kang, Scott P. Kennedy, Flossie Wong-Staal, Mang Yu, Michael Mamounas, James R. Merson, Elizabeth Duarte, Yu Feng, Jack R. Barber, Mark C. Leavitt, Patrick N. Gilles, Richard Tritz

Publikováno v: Virology. 276:271-278

CCR-5 is a major cellular coreceptor for R5 strains of HIV-1. Individuals carrying a homozygous 32-base-pair deletion in this gene are apparently healthy and are relatively resistant to HIV-1 infection. Since CCR5 appears to be dispensable for the ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519dc6d5c630503d9afb2dade699216a
https://doi.org/10.1006/viro.2000.0536

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Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance

Autor: Mark C. Leavitt, Peter E. Thelwall, Joseph V. Rutkowski, Christian Thoma, Kieren G. Hollingsworth, Fiona E. Smith, Andrew M. Blamire, Anthony G. Quinn, Roy Taylor, W Hu, Michael I. Trenell, David Canty

Publikováno v: Journal of Hepatology

Background & aims Lysosomal Acid Lipase (LAL) deficiency is a rare metabolic storage disease, caused by a marked reduction in activity of LAL, which leads to accumulation of cholesteryl esters (CE) and triglycerides (TG) in lysosomes in many tissues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ca7716bd08431ccf6dcf436daa1d26
https://pubmed.ncbi.nlm.nih.gov/23624251

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Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1

Autor: Osamu Yamada, Mang Yu, Anthony D. Ho, Dennis J. Young, Mark C. Leavitt, Flossie Wong-Staal, Midori Maruyama

Publikováno v: Proceedings of the National Academy of Sciences. 92:699-703

Successful treatment of human immunodeficiency virus infection may ultimately require targeting of hematopoietic stem cells. Here we used retroviral vectors carrying the ribozyme gene to transduce CD34+ cells from human fetal cord blood. Transduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4811430cde42224674e2ffd4026bde
https://doi.org/10.1073/pnas.92.3.699

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In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1

Autor: Eric M. Poeschla, Paula Degrandis, Mark C. Leavitt, Marina Heusch, Flossie Wong-Stahl, Jiing Kuala Yees, Arnold Hampel, Mang Yu, Osamu Yamada

Publikováno v: Virology. 206:381-386

We have constructed a hairpin ribozyme targeted to cleave a conserved sequence in the HIV-1 pol gene. The ribozymewas modified to include a structure-stabilizing tetraloop. In vitro studies revealed a cleavage efficiency unprecedented for hairpin rib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825827e493de1190a862f7f39e8d5712
https://doi.org/10.1016/s0042-6822(95)80053-0

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Activity and Cleavage Site Specificity of an Anti-HIV-1 Hairpin Ribozyme in Human T Cells

Autor: Günter Kraus, Flossie Wong-Staal, Mang Yu, Mark C. Leavitt, Osamu Yamada

Publikováno v: Virology. 205:121-126

Human CD4+ T cells (Molt-4) were transduced with retrovital vectors containing a hairpin ribozyme which targets the rev/env coding region of HIV-1 RNA (HXB2: 8629-8644). This target sequence is conserved among many HIV-1 clones, including the prototy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d79158cce44bd7e1f270600d215957
https://doi.org/10.1006/viro.1994.1626

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Transfer of an Anti-HIV-1 Ribozyme Gene into Primary Human Lymphocytes

Autor: David Looney, Eric M. Poeschla, Flossie Wong-Staal, Mark C. Leavitt, Mang Yu, Osamu Yamada, Günter Kraus

Publikováno v: Human Gene Therapy. 5:1115-1120

We reported previously that human CD4+ T cell lines stably expressing a hairpin ribozyme targeted to the human immunodeficiency virus type 1 (HIV-1) U5 leader sequence were resistant to challenge with diverse HIV-1 viral clones and clinical isolates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92aac0473c9c4e74710fe428ce76c5a0
https://doi.org/10.1089/hum.1994.5.9-1115

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Site-specific mutagenesis of PRD1 DNA polymerase: Mutations in highly conserved regions of the family B DNA polymerase

Autor: Junetsu Ito, Michelle Schultz, Mark C. Leavitt, Guhung Jung

Publikováno v: Biochemical and Biophysical Research Communications. 170:1294-1300

The PRD1 DNA polymerase is a small multifunctional enzyme containing three major conserved amino acid sequences shared by family B DNA polymerases. Thus, the PRD1 DNA polymerase provides an useful model system with which to study structure-function r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3ba4bf9f79e4fa8e38ac119fc3682c
https://doi.org/10.1016/0006-291x(90)90534-t

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