Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mark C. Emerick"'
Publikováno v:
Neuroscience Letters. 269:121-124
The structure of CACNA1I, the gene encoding alpha1I, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 36 exons spanning at
Penalized likelihood for sparse contingency tables with an application to full-length cDNA libraries
Publikováno v:
BMC Bioinformatics, Vol 8, Iss 1, p 476 (2007)
BMC Bioinformatics, 8
BMC Bioinformatics
BMC Bioinformatics, 8
BMC Bioinformatics
Background The joint analysis of several categorical variables is a common task in many areas of biology, and is becoming central to systems biology investigations whose goal is to identify potentially complex interaction among variables belonging to
Publikováno v:
BMC Bioinformatics, Vol 8, Iss 1, p 16 (2007)
BMC Bioinformatics
BMC Bioinformatics
Background RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with unpredictable phenotypic consequences, necessitating integrated RNA-level regulat
Autor:
Rebecca Stein, Mark C. Emerick, Robin Kunze, Dorothy A. Hanck, Melissa R. Regan, Megan M. McNulty, William S. Agnew
Publikováno v:
Proteins. 64(2)
We describe the regulated transcriptome of CACNA1G, a human gene for T-type Ca v 3.1 calcium channels that is subject to extensive alternative RNA splicing. Fifteen sites of transcript variation include 2 alternative 5'-UTR promoter sites, 2 alternat
Publikováno v:
Proteins. 59(2)
The domain structure of proteins synthesized from a single gene can be remodeled during tissue development by activities at the RNA level of gene expression. The impact of higher order RNA processing on changing patterns of protein domain selection m
Publikováno v:
Analytical biochemistry. 286(2)
Alternative splicing of pre-mRNA may generate many distinct proteins from a single gene: regulation of alternative exon selection constitutes control of molecular structure downstream of transcription. Identifying natural splice variants among hundre
Publikováno v:
Biochemistry. 32(36)
Previous studies have shown that the short-motif electroplax Na channel is phosphorylated in vitro by cyclic AMP-dependent protein kinase (PKA) at serines 6 or 7 and 1776 and threonine 17 (Emerick & Agnew, 1989). We here show that phosphatase treatme
Publikováno v:
Biochemistry. 28:6001-6009
The voltage-sensitive sodium channel present in the eel (Electrophorus electricus) has an unusually high content of sialic acid, including {alpha}-(2{yields}8)-linked polysialic acid, not found in other electroplax membrane glycopeptides. Lectins fro
Publikováno v:
Biochemistry. 25:2162-2174
A fluorescence assay for measuring Na channel activation in liposomes containing voltage-sensitive Na channels isolated from Electrophorus electricus is described. The assay is based on transport of a heavy-metal cation, T1+, through the activated ch
Publikováno v:
Annals of the New York Academy of Sciences. 479:238-256