Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Mark C. Butler"'
Autor:
Sriganesh Ramachandra Rao, Lara A. Skelton, Fuguo Wu, Agnieszka Onysk, Grzegorz Spolnik, Witold Danikiewicz, Mark C. Butler, Delores A. Stacks, Liliana Surmacz, Xiuqian Mu, Ewa Swiezewska, Steven J. Pittler, Steven J. Fliesler
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101198- (2020)
Summary: Dehydrodolichyl diphosphate synthase (DHDDS) catalyzes the committed step in dolichol synthesis. Recessive mutations in DHDDS cause retinitis pigmentosa (RP59), resulting in blindness. We hypothesized that rod photoreceptor-specific ablation
Externí odkaz:
https://doaj.org/article/81a55c7b9d8749cbbf5fd2924ed7aa4e
Autor:
Mark C. Butler, Sriganesh Ramachandra Rao, Delores A. Stacks, Agnieszka Onysk, Fuguo Wu, Liliana Surmacz, Lara A. Skelton, Xiuqian Mu, Steven J. Fliesler, Ewa Swiezewska, Witold Danikiewicz, Steven J. Pittler, Grzegorz Spólnik
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101198-(2020)
iScience
iScience
Summary Dehydrodolichyl diphosphate synthase (DHDDS) catalyzes the committed step in dolichol synthesis. Recessive mutations in DHDDS cause retinitis pigmentosa (RP59), resulting in blindness. We hypothesized that rod photoreceptor-specific ablation
Publikováno v:
Retinal Degenerative Diseases ISBN: 9783030273774
Hammerhead ribozymes (hhRzs), RNA enzymes capable of site-specific cleavage of arbitrary target mRNAs, have faced significant hurdles in development and optimization as gene therapeutics for clinical translation. Chemical and biological barriers must
Autor:
Eric D. Walter, Ryan S. Renslow, Mark C. Butler, Hardeep S. Mehta, Karl T. Mueller, Ying Chen, Nancy M. Washton, Patrick N. Reardon
Publikováno v:
Phys. Chem. Chem. Phys.. 19:28163-28174
We present the numerical optimization and experimental characterization of two microstrip-based nuclear magnetic resonance (NMR) detectors. The first detector, introduced in our previous work, was a flat wire detector with a strip resting on a substr
Publikováno v:
Experimental Eye Research. 151:236-255
Major bottlenecks in development of therapeutic post transcriptional gene silencing ( PTGS ) agents (e.g. ribozymes, RNA interference, antisense) include the challenge of mapping rare accessible regions of the mRNA target that are open for annealing
Autor:
Edwin H. Yau, Robert T. Taggart, Mohammed Zuber, Dian Yu, Jack M. Sullivan, Mark C. Butler, Jennifer B. Breen, Zahra Fayazi, Alexandria J Trujillo, Lowell G. Sheflin
Publikováno v:
Translational Vision Science & Technology
Purpose To systematically evaluate human rod opsin (hRHO) mRNA for potential target sites sensitive to posttranscriptional gene silencing (PTGS) by hammerhead ribozyme (hhRz) or RNA interference (RNAi) in human cells. To develop a comprehensive strat
Autor:
Ying Chen, Michael T. Khbeis, Patrick N. Reardon, Ryan S. Renslow, Hardeep S. Mehta, Mark C. Butler, Karl T. Mueller, Duane Irish
Publikováno v:
Physical chemistry chemical physics : PCCP. 19(22)
A longstanding limitation of high-resolution NMR spectroscopy is the requirement for samples to have macroscopic dimensions. Commercial probes, for example, are designed for volumes of at least 5 μL, in spite of decades of work directed toward the g
Autor:
Thomas Theis, Alexander Pines, Dmitry Budker, John W. Blanchard, Mark C. Butler, Micah P. Ledbetter
Publikováno v:
Chemical Physics Letters. 580:160-165
Zero-field nuclear magnetic resonance (NMR) spectroscopy is emerging as a new, potentially portable, and cost-effective NMR modality with the ability to provide information-rich, high-resolution spectra. We present simple rules for analysis of zero-f
Publikováno v:
Vision Research. 48(3):453-469
Development of post-transcriptional gene silencing (PTGS) agents for therapeutic purposes is an immense challenge in modern biology. Established technologies used to knockdown a specific target RNA and its cognate protein: antisense, ribozyme, RNAi,
Autor:
Haijing Wang, Chang S. Shin, Ren-Bao Liu, Vikram S. Bajaj, Claudia E. Avalos, Alexander Pines, Mark C. Butler, Scott J. Seltzer
Publikováno v:
Physical Review B. 89
We report sensitive detection of the nuclear quadrupolar interaction of the $^{14}\mathrm{N}$ nuclear spin of the nitrogen-vacancy (NV) center using the electron spin-echo envelope modulation technique. We applied a weak transverse magnetic field to