Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Mark C. Allen"'
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Akademický článek
Time-of-Flight MRA of Intracranial Aneurysms with Interval Surveillance, Clinical Segmentation and Annotations
Autor: Chloe M. de Nys, Ee Shern Liang, Marita Prior, Maria A. Woodruff, James I. Novak, Ashley R. Murphy, Zhiyong Li, Craig D. Winter, Mark C. Allenby
Publikováno v: Scientific Data, Vol 11, Iss 1, Pp 1-10 (2024)
Abstract Intracranial aneurysms (IAs) are present in 2–6% of the global population and can be catastrophic upon rupture with a mortality rate of 30–50%. IAs are commonly detected through time-of-flight magnetic resonance angiography (TOF-MRA), ho
Externí odkaz: https://doaj.org/article/40e014c977064e4e83b1769332fb16eb
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2
Synthesis of somatostatin analogs resistant to the action of trypsin
Autor: Mark C. Allen, R. Wade
Publikováno v: International Journal of Peptide and Protein Research. 32:89-97
The synthesis of a series of octapeptides based on the somatostatin analog cyclo(-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Gaba-) containing the substitutions [Aap9], [D-Lys9], [L-Trp8, D-Lys9], [L-Orn9] and [D-aThr10] is reported. The analogs were designed and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd1a35c28d594bef2165b64c4fd65c5
https://doi.org/10.1111/j.1399-3011.1988.tb00668.x
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3
Fine-scale habitat selection of foraging bottlenose dolphins Tursiops truncatus near Clearwater, Florida
Autor: Mark C. Allen, Jocelyn Gaudet, Andrew J. Read, Laela S. Sayigh
Publikováno v: Marine Ecology Progress Series. 222:253-264
Previous studies have proposed that seagrass habitats, by supporting diverse and abun- dant fish assemblages, are preferred by foraging dolphins in coastal systems. To test this hypothesis, we (1) examined the fine-scale behavior of bottlenose dolphi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29165307b37b258111cea3a35504e6c
https://doi.org/10.3354/meps222253
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5
the design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors
Autor: Judy Hayler, Mark Talbot, Xiaoling Cockcroft, Nicholas Wills, Florence Lugrin, Keith Menear, K D Butler, Richard Price, John Ambler, Andrew Mitchelson, Peter D. Kane, Darren Mark Legrand, Karren Dunnet, Mark C. Allen, Morris Tweed
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:1567-1570
The further optimisation of the novel lead compound CGH752 (Fig. 1) is described. By introducing various substituents into the 6-position of the 3,3-dimethyltetrahydroquinoline (DMTHQS) ring we have been able to favourably affect the in vitro and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53facba3ef723980cf4b0000c32556a1
https://doi.org/10.1016/s0960-894x(00)00283-3
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6
[7-Methyltryptophan 9] -β-corticotropin-(1-24): a hyperactive Synacthen analogue
Autor: P.D. Bailey, R. Wade, Mark C. Allen, Geoffrey T. Young, John H. Jones, Derek E. Brundish
Publikováno v: International Journal of Peptide and Protein Research. 24:529-531
[7-Methyltryptophan9]-beta-corticotropin-(1-24) has been synthesised. In an isolated adrenal cell bioassay, it has 2.7 times the steroidogenic activity of beta-corticotropin-(1-24) (Synacthen).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe760a3b1d04ab2fb702b1017ff1b02f
https://doi.org/10.1111/j.1399-3011.1984.tb03155.x
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7
Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency
Autor: Graham Arton Howarth, Talbot, Judy Hayler, Garrick Smith, Derek E. Brundish, Wakeford R, John Ambler, Mark C. Allen, Joseph D. Fullerton, Peter D. Kane, Christoph Walker, Sheila Garman, Donovan, Bull A, K D Butler, William Hoyle, Diana Janus, McDonnell M
Publikováno v: Journal of Medicinal Chemistry. 42:4584-4603
Mitsubishi's MD-805, a potent and selective inhibitor of thrombin which contains four stereogenic centers, has been the starting point for an optimization program. A systematic synthetic study resulted in thrombin inhibitors achiral at P2 and P3 but
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6622861e59d1bf122b24db6df96f42fb
https://doi.org/10.1021/jm9811209
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8
[Untitled]
Autor: Xiao Ling Fan Cockcroft, Mark C. Allen, Markus Gruetter, John P. Priestle
Publikováno v: Journal of Computer-Aided Molecular Design. 13:579-588
This paper describes the construction, validation and application of an active site model of the serine protease thrombin. Initial use was made of medium resolution X-ray crystallographic structures of thrombin complexed with low molecular weight, no
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1131beed94c52cb32147b30aae683fd
https://doi.org/10.1023/a:1008098615891
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10
Display of fixed residues on variable cyclic scaffolds: A novel approach to peptide combinatorial library synthesis
Autor: Ian Sanders, Ian M. Matthews, Malcolm M. Campbell, Mark C. Allen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2603-2606
A synthetic peptide library is described which displays three nominated residues in varied spacing around cyclic peptides. Diversity of ring size was achieved by the use of binary combinatorial synthesis, and the inclusion of hydrophilic spacer molec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::556322c061802ccc78bfbc34404d839a
https://doi.org/10.1016/s0960-894x(97)10026-9
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