Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Mark C Horowitz"'
Autor:
Basel M. Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese, Daniel Brooks, Steven M. Tommasini, Mary L. Bouxsein, Mark C. Horowitz, Clifford J. Rosen, Kevin Nguyen, Samuel Haddox, Emily A. Farber, Suna Onengut-Gumuscu, Daniel Pomp, Charles R. Farber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying ne
Externí odkaz:
https://doaj.org/article/4e2ac2ef78f74d52bdfce93123908f3a
Autor:
Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Megi Resulaj, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth K. O’Donnell, Ormond A. MacDougald, Mark C. Horowitz, Clifford J. Rosen, Anne Klibanski
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
BACKGROUND Adipocytes were long considered inert components of the bone marrow niche, but mouse and human models suggest bone marrow adipose tissue (BMAT) is dynamic and responsive to hormonal and nutrient cues.METHODS In this study of healthy volunt
Externí odkaz:
https://doaj.org/article/f9b9b856c1e14301bb81e9b24e87630a
Autor:
Josefine Tratwal, Rossella Labella, Nathalie Bravenboer, Greet Kerckhofs, Eleni Douni, Erica L. Scheller, Sammy Badr, Dimitrios C. Karampinos, Sarah Beck-Cormier, Biagio Palmisano, Antonella Poloni, Maria J. Moreno-Aliaga, Jackie Fretz, Matthew S. Rodeheffer, Parastoo Boroumand, Clifford J. Rosen, Mark C. Horowitz, Bram C. J. van der Eerden, Annegreet G. Veldhuis-Vlug, Olaia Naveiras
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation, chemot
Externí odkaz:
https://doaj.org/article/929e88673c9c403abff3407ea2ce9664
Autor:
Thomas M. Jeitner, Juan A. Azcona, Gene P. Ables, Diana Cooke, Mark C. Horowitz, Pradeep Singh, James M. Kelly, Arthur J. L. Cooper
Publikováno v:
GeroScience.
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the trans
Autor:
Thomas O. Carpenter, Björn Busse, Dillon Kavanagh, Simon von Kroge, Paul R. Stabach, Demetrios T. Braddock, Mark C. Horowitz, Thorsten Schinke, Nathan D. Maulding, Michael Amling, Kristin Zimmerman, Ralf Oheim, Uwe Kornak, Steven M. Tommasini, Julian Stürznickel, David B. Thompson
Publikováno v:
Journal of Bone and Mineral Research
Biallelic ENPP1 deficiency in humans induces generalized arterial calcification of infancy (GACI) and/or autosomal recessive hypophosphatemic rickets type 2 (ARHR2). The latter is characterized by markedly increased circulating FGF23 levels and renal
Autor:
Charles R. Farber, Clifford J. Rosen, Larry D. Mesner, Daniel J. Brooks, Steven M. Tommasini, Emily Farber, Kevin Nguyen, Samuel Haddox, Basel M. Al-Barghouthi, Suna Onengut-Gumuscu, Daniel Pomp, Mark C. Horowitz, Gina M. Calabrese, Mary L. Bouxsein
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, w
Autor:
Elena Torreggiani, Brya G Matthews, Slavica Pejda, Igor Matic, Mark C Horowitz, Danka Grcevic, Ivo Kalajzic
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75204 (2013)
Presently there is no clear evidence for the ability of mature osteogenic lineage cells to dedifferentiate. In order to identify and trace mature osteogenic lineage cells, we have utilized transgenic mouse models in which the dentin matrix protein 1
Externí odkaz:
https://doaj.org/article/39cf3f9c31e74de9a7766eb609ee49cc
Autor:
Emily Farber, Daniel Pomp, Basel M. Al-Barghouthi, Daniel J. Brooks, Steven M. Tommasini, Gina M. Calabrese, Suna Onengut-Gumuscu, Mary L. Bouxsein, Samuel Haddox, Larry D. Mesner, Mark C. Horowitz, Kevin Nguyen, Charles R. Farber, Clifford J. Rosen
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0ad02df6e35e603a5a6af2420e620b
https://doi.org/10.1101/2020.06.24.169839
https://doi.org/10.1101/2020.06.24.169839
Autor:
Sai P. Polineni, Xun Zhang, Alexander T. Faje, Ormond A. MacDougald, Miriam A. Bredella, Clifford J. Rosen, Mark C. Horowitz, Pouneh K. Fazeli, Elizabeth O'Donnell, Megi Resulaj, Wenxiu Zhao, Hang Lee, Tara M. Holmes, Olga Gisela Pachon-Peña, Anne Klibanski
Publikováno v:
JCI Insight
BACKGROUND Adipocytes were long considered inert components of the bone marrow niche, but mouse and human models suggest bone marrow adipose tissue (BMAT) is dynamic and responsive to hormonal and nutrient cues. METHODS In this study of healthy volun
Autor:
Ying-Hua Cheng, Robyn K. Fuchs, Haley McGough, David J. Olivos, Pierre P. Eleniste, Richard Adam Hooker, Marta Alvarez, Edward F. Srour, Mark C. Horowitz, Christopher Yim, Wendy A. Ciovacco, Monique Bethel, Angela Bruzzaniti, Brahmananda R. Chitteti, Melissa A. Kacena
Publikováno v:
Journal of Cellular Biochemistry. 118:2231-2240
The Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor. Lnk-deficient (-/-) mice have increased TPO signaling and increased MK number. Interestingly, several mouse models exist in