Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Mark C Gillies"'
Autor:
Ting Zhang, Ling Zhu, Michele C Madigan, Wei Liu, Weiyong Shen, Svetlana Cherepanoff, Fanfan Zhou, Shaoxue Zeng, Jianhai Du, Mark C Gillies
Publikováno v:
eLife, Vol 8 (2019)
The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells. We found primary
Externí odkaz:
https://doaj.org/article/2448b4f984bc421eb82e42f57438ca08
Autor:
Mohammad R Irhimeh, Mohamed Hamed, Daniel Barthelmes, Yvonne Gladbach, Volkhard Helms, Weiyong Shen, Mark C Gillies
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200194 (2018)
Endothelial progenitor cells (EPCs) are a group of rare cells that play an important role in the repair of injured vascular endothelial cells and assist in reperfusion of ischemic tissue. Decreased production and/or loss of function of EPCs are assoc
Externí odkaz:
https://doaj.org/article/2cddff5ff9f345dc866bb029380ab313
Autor:
Gonzaga Garay-Aramburu, Adrian Hunt, Carolina Arruabarrena, Hemal Mehta, Alessandro Invernizzi, Pierre-Henry Gabrielle, Tremeur Guillaumie, Benjamin Wolff, Mark C. Gillies, Javier Zarranz-Ventura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To compare baseline characteristics, initial response and 12-month efficacy and safety outcomes in eyes with branch and central retinal vein occlusion (BRVO and CRVO) treated with dexamethasone implants (DEX) or anti-vascular endothelial gro
Externí odkaz:
https://doaj.org/article/48c739c504584db782d395785221afbb
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120760 (2015)
Diabetes mellitus is a chronic metabolic disorder that significantly affects human health and well-being. The Solute carrier transporters (SLCs), particularly the Organic anion/cation transporters (Oats/Octs/Octns), Organic anion transporting polypep
Externí odkaz:
https://doaj.org/article/8cd21bb9c18f43189e7bc98c817a8d07
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104759 (2014)
OBJECTIVE: Royal College of Surgeons (RCS) rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO) on retinopathy in RCS rats. METHODS: Fluorescein angiography was used to monito
Externí odkaz:
https://doaj.org/article/1c7efeebef4140ceb546baee66cef83c
Autor:
Nancy L Parmalee, Carl Schubert, Maria Figueroa, Alan C Bird, Tunde Peto, Mark C Gillies, Paul S Bernstein, Krzysztof Kiryluk, Joseph D Terwilliger, Rando Allikmets, MacTel Project
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e24268 (2012)
Macular Telangiectasia type 2 (MacTel) is a relatively rare macular disease of adult onset presenting with distortions in the visual field and leading to progressive loss of visual acuity. For the purpose of a gene mapping study, several pedigrees we
Externí odkaz:
https://doaj.org/article/a4021802fff3479baf46d61875036bf0
Autor:
Eloi Debourdeau, Robin Medard, Chloe Chamard, Vuong Nguyen, Pierre Henry Gabrielle, Catherine Creuzot-Garcher, Sandrine Allieu, Mark C. Gillies, Daniel Barthelmes, Vincent Daien, the Fight Retinal Blindness! Study Group
Publikováno v:
Ophthalmology and Therapy, Vol 12, Iss 5, Pp 2657-2670 (2023)
Abstract Introduction Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for diabetic macular edema (DME). We investigated the effect of initial glycosylated hemoglobin (HbA1c) level and glomerular filtration rate (GFR
Externí odkaz:
https://doaj.org/article/8caf29da7da94cc8bccf443c7c6136b4
Autor:
Lay Khoon Too, Weiyong Shen, Dario A. Protti, Atomu Sawatari, Dylan A. Black, Catherine A. Leamey, Jin Y. Huang, So-Ra Lee, Ashish E. Mathai, Leszek Lisowski, John Y. Lin, Mark C. Gillies, Matthew P. Simunovic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The common final pathway to blindness in many forms of retinal degeneration is the death of the light-sensitive primary retinal neurons. However, the normally light-insensitive second- and third-order neurons persist optogenetic gene therapy
Externí odkaz:
https://doaj.org/article/e6ac0f842ad64bb388befe61565632fa
Autor:
Jialing Zhang, Ting Zhang, Shaoxue Zeng, Xinyuan Zhang, Fanfan Zhou, Mark C. Gillies, Ling Zhu
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1512 (2023)
Age-related diseases, such as Parkinson’s disease, Alzheimer’s disease, cardiovascular diseases, cancers, and age-related macular disease, have become increasingly prominent as the population ages. Oxygen is essential for living organisms, but it
Externí odkaz:
https://doaj.org/article/1e49f6d1b4b844d3badb0d3f07cffa7e
Autor:
Yingying Chen, Nathan J. Coorey, Meixia Zhang, Shaoxue Zeng, Michele C. Madigan, Xinyuan Zhang, Mark C. Gillies, Ling Zhu, Ting Zhang
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 942 (2022)
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox
Externí odkaz:
https://doaj.org/article/a4757895ac1243f7a25b0566e7659e21