Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Mark C Field"'
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Autor:
Aarthi Kuppannan, Yu-Yang Jiang, Wolfgang Maier, Chang Liu, Charles F Lang, Chao-Yin Cheng, Mark C Field, Minglei Zhao, Martin Zoltner, Aaron P Turkewitz
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010194 (2022)
In the ciliate Tetrahymena thermophila, lysosome-related organelles called mucocysts accumulate at the cell periphery where they secrete their contents in response to extracellular events, a phenomenon called regulated exocytosis. The molecular bases
Externí odkaz:
https://doaj.org/article/64658e179f64424eb43c40327eb131f2
Autor:
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Autor:
Juan F Quintana, Juan Bueren-Calabuig, Fabio Zuccotto, Harry P de Koning, David Horn, Mark C Field
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008458 (2020)
Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel asso
Externí odkaz:
https://doaj.org/article/f3985bc0ed7a43708934feb0f30f6f83
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006679 (2018)
Poly(A)-binding proteins (PABPs) regulate mRNA fate by controlling stability and translation through interactions with both the poly(A) tail and eIF4F complex. Many organisms have several paralogs of PABPs and eIF4F complex components and it is likel
Externí odkaz:
https://doaj.org/article/d2825a52d94446948f8dbee32b40b56d
Autor:
Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren J Creek, Yvonne Freund, Robert Jacobs, Kevin Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006450 (2018)
The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regime
Externí odkaz:
https://doaj.org/article/bf067d73fa9f4661ba5f3af2533cc24f
Autor:
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006850 (2018)
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However
Externí odkaz:
https://doaj.org/article/15b9266be10f461686b0efc0aad70326
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006310 (2017)
The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replicatio
Externí odkaz:
https://doaj.org/article/5b688e6a898447f8bf63b30a93854c3e
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006170 (2017)
Externí odkaz:
https://doaj.org/article/1ced8726cfbf47fabffd55469c9607ce
Autor:
Cordula M Boehm, Samson Obado, Catarina Gadelha, Alexandra Kaupisch, Paul T Manna, Gwyn W Gould, Mary Munson, Brian T Chait, Michael P Rout, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006063 (2017)
Membrane transport is an essential component of pathogenesis for most infectious organisms. In African trypanosomes, transport to and from the plasma membrane is closely coupled to immune evasion and antigenic variation. In mammals and fungi an octam
Externí odkaz:
https://doaj.org/article/2b9e911be4934c5db25bf5b35a8444c0