Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Mark C Bellingham"'
Autor:
Monika Gaik, Marija Kojic, Megan R Stegeman, Tülay Öncü‐Öner, Anna Kościelniak, Alun Jones, Ahmed Mohamed, Pak Yan Stefanie Chau, Sazia Sharmin, Andrzej Chramiec‐Głąbik, Paulina Indyka, Michał Rawski, Anna Biela, Dominika Dobosz, Amanda Millar, Vann Chau, Aycan Ünalp, Michael Piper, Mark C Bellingham, Evan E Eichler, Deborah A Nickerson, Handan Güleryüz, Nour El Hana Abbassi, Konrad Jazgar, Melissa J Davis, Saadet Mercimek‐Andrews, Sultan Cingöz, Brandon J Wainwright, Sebastian Glatt
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 7, Pp n/a-n/a (2022)
Abstract The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological diseases, and brain tumors. Numerous clinically relevant variants have been reported in the catalytic Elp123 sub
Externí odkaz:
https://doaj.org/article/f87fbaa46ca24838baab46a1729467a8
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106614- (2024)
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a tri
Externí odkaz:
https://doaj.org/article/9b188baf16d24c7cb9c3cb629ea735bb
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In amyotrophic lateral sclerosis (ALS) postmortem tissue and the SOD1 mouse model at mid-disease, death of hypoglossal motor neurons (XII MNs) is evident. These XII MNs innervate the intrinsic and extrinsic tongue muscles, and despite their importanc
Externí odkaz:
https://doaj.org/article/200989ceacc844b09f2bd1a936ff92f2
Autor:
Matthew J Fogarty, Karen L Smallcombe, Yuchio Yanagawa, Kunihiko Obata, Mark C Bellingham, Peter G Noakes
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56257 (2013)
Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor
Externí odkaz:
https://doaj.org/article/2635884d15ea4b59a7cf284c940a482b
Publikováno v:
The Anatomical Record. 304:1562-1581
The total motor neuron (MN) somato-dendritic surface area is correlated with motor unit type. MNs with smaller surface areas innervate slow (S) and fast fatigue-resistant (FR) motor units, while MNs with larger surface areas innervate fast fatigue-in
Publikováno v:
International journal of molecular sciences. 23(14)
Normal development and function of the central nervous system involves a balance between excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons is modulated by inhibitory signalling of the GABAergic and glycin
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Motoneurons develop extensive dendritic trees for receiving excitatory and inhibitory synaptic inputs to perform a variety of complex motor tasks. At birth, the somatodendritic domains of mouse hypoglossal and lumbar motoneurons have dense filopodia
Externí odkaz:
https://doaj.org/article/1ceb063d6e4243cab8daac48551939ca
Publikováno v:
The Anatomical Record. 303:1455-1471
The motor neuron (MN) soma surface area is correlated with motor unit type. Larger MNs innervate fast fatigue-intermediate (FInt) or fast-fatiguable (FF) muscle fibers in type FInt and FF motor units, respectively. Smaller MNs innervate slow-twitch f
Publikováno v:
Progress in Neurobiology. 214:102282
Once widely considered an immune-privileged organ, the brain is now known to be intimately intertwined with immune-system activation. In particular, the complement system, an enzymatic cascade conferring innate immunity, has crucial functions for sev
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 19:112-129