Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Mark C, Gillies"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Subretinal fibrosis is a major untreatable cause of poor outcomes in neovascular age-related macular degeneration. Mouse models of subretinal fibrosis all possess a degree of invasiveness and tissue damage not typical of fibrosis progression
Externí odkaz:
https://doaj.org/article/3d99e796ddfc453db479320cfff8bc8b
Autor:
Gonzaga Garay-Aramburu, Adrian Hunt, Carolina Arruabarrena, Hemal Mehta, Alessandro Invernizzi, Pierre-Henry Gabrielle, Tremeur Guillaumie, Benjamin Wolff, Mark C. Gillies, Javier Zarranz-Ventura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To compare baseline characteristics, initial response and 12-month efficacy and safety outcomes in eyes with branch and central retinal vein occlusion (BRVO and CRVO) treated with dexamethasone implants (DEX) or anti-vascular endothelial gro
Externí odkaz:
https://doaj.org/article/48c739c504584db782d395785221afbb
Autor:
Eloi Debourdeau, Robin Medard, Chloe Chamard, Vuong Nguyen, Pierre Henry Gabrielle, Catherine Creuzot-Garcher, Sandrine Allieu, Mark C. Gillies, Daniel Barthelmes, Vincent Daien, the Fight Retinal Blindness! Study Group
Publikováno v:
Ophthalmology and Therapy, Vol 12, Iss 5, Pp 2657-2670 (2023)
Abstract Introduction Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for diabetic macular edema (DME). We investigated the effect of initial glycosylated hemoglobin (HbA1c) level and glomerular filtration rate (GFR
Externí odkaz:
https://doaj.org/article/8caf29da7da94cc8bccf443c7c6136b4
Autor:
Lay Khoon Too, Weiyong Shen, Dario A. Protti, Atomu Sawatari, Dylan A. Black, Catherine A. Leamey, Jin Y. Huang, So-Ra Lee, Ashish E. Mathai, Leszek Lisowski, John Y. Lin, Mark C. Gillies, Matthew P. Simunovic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The common final pathway to blindness in many forms of retinal degeneration is the death of the light-sensitive primary retinal neurons. However, the normally light-insensitive second- and third-order neurons persist optogenetic gene therapy
Externí odkaz:
https://doaj.org/article/e6ac0f842ad64bb388befe61565632fa
Autor:
Yingying Chen, Ting Zhang, Shaoxue Zeng, Rong Xu, Kaiyu Jin, Nathan J. Coorey, Yekai Wang, Ke Wang, So-Ra Lee, Michelle Yam, Meidong Zhu, Andrew Chang, Xiaohui Fan, Meixia Zhang, Jianhai Du, Mark C. Gillies, Ling Zhu
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102379- (2022)
The Pentose Phosphate Pathway (PPP), a metabolic offshoot of the glycolytic pathway, provides protective metabolites and molecules essential for cell redox balance and survival. Transketolase (TKT) is the critical enzyme that controls the extent of
Externí odkaz:
https://doaj.org/article/0ce3a94aebc246339b810da98df48f47
Autor:
Jialing Zhang, Ting Zhang, Shaoxue Zeng, Xinyuan Zhang, Fanfan Zhou, Mark C. Gillies, Ling Zhu
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1512 (2023)
Age-related diseases, such as Parkinson’s disease, Alzheimer’s disease, cardiovascular diseases, cancers, and age-related macular disease, have become increasingly prominent as the population ages. Oxygen is essential for living organisms, but it
Externí odkaz:
https://doaj.org/article/1e49f6d1b4b844d3badb0d3f07cffa7e
Autor:
Yingying Chen, Nathan J. Coorey, Meixia Zhang, Shaoxue Zeng, Michele C. Madigan, Xinyuan Zhang, Mark C. Gillies, Ling Zhu, Ting Zhang
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 942 (2022)
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox
Externí odkaz:
https://doaj.org/article/a4757895ac1243f7a25b0566e7659e21
Autor:
Shaoxue Zeng, Ting Zhang, Michele C. Madigan, Nilisha Fernando, Riemke Aggio-Bruce, Fanfan Zhou, Matthew Pierce, Yingying Chen, Lianlin Huang, Riccardo Natoli, Mark C. Gillies, Ling Zhu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors. Enriched in the interphotoreceptor matrix (IPM) and recycled by the retinal pigm
Externí odkaz:
https://doaj.org/article/35c009e72c364723a4b6a061812fc752
Autor:
Bo Li, Ting Zhang, Wei Liu, Yekai Wang, Rong Xu, Shaoxue Zeng, Rui Zhang, Siyan Zhu, Mark C. Gillies, Ling Zhu, Jianhai Du
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101672- (2020)
Summary: Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is
Externí odkaz:
https://doaj.org/article/354036a6aa874d01b92f8a62b43159a3
Autor:
Patricia S. Graham, Georgia Kaidonis, Sotoodeh Abhary, Mark C. Gillies, Mark Daniell, Rohan W. Essex, John H. Chang, Stewart R. Lake, Bishwanath Pal, Alicia J. Jenkins, Alex W. Hewitt, Ecosse L. Lamoureux, Philip G. Hykin, Nikolai Petrovsky, Matthew A. Brown, Jamie E. Craig, Kathryn P. Burdon
Publikováno v:
BMC Medical Genetics, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Background Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopath
Externí odkaz:
https://doaj.org/article/8e3a89c206f54a43bd525319b6d5c064