Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Mark C, Field"'
Autor:
Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
ABSTRACTThe nuclear envelope (NE) separates translation and transcription and is the location of multiple functions, including chromatin organization and nucleocytoplasmic transport. The molecular basis for many of these functions have diverged betwe
Externí odkaz:
https://doaj.org/article/ae18073f1f5e4692a04948d564b2452b
Autor:
Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field, David Horn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African
Externí odkaz:
https://doaj.org/article/16ff35d784f44ce5b0d4ec6740ef38bd
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Autor:
Alexandr Makarov, Jakub Began, Ileana Corvo Mautone, Erika Pinto, Liam Ferguson, Martin Zoltner, Sebastian Zoll, Mark C. Field
Publikováno v:
Microbial Cell, Vol 10, Iss 2, Pp 18-35 (2023)
The surface proteins of parasitic protozoa mediate functions essential to survival within a host, including nutrient accumulation, environmental sensing and immune evasion. Several receptors involved in nutrient uptake and defence from the innate imm
Externí odkaz:
https://doaj.org/article/74409ac2850f48418d2bea46728c3d49
Autor:
Drahomíra Faktorová, Kristína Záhonová, Corinna Benz, Joel B. Dacks, Mark C. Field, Julius Lukeš
Publikováno v:
Open Biology, Vol 13, Iss 6 (2023)
The β-propeller protein Sec13 plays roles in at least three distinct processes by virtue of being a component of the COPII endoplasmic reticulum export vesicle coat, the nuclear pore complex (NPC) and the Seh1-associated (SEA)/GATOR nutrient-sensing
Externí odkaz:
https://doaj.org/article/c6b60f25cd1044419d212248fa8dde1d
Autor:
ThankGod Echezona Ebenezer, Ross S. Low, Ellis Charles O'Neill, Ishuo Huang, Antonio DeSimone, Scott C. Farrow, Robert A. Field, Michael L. Ginger, Sergio Adrián Guerrero, Michael Hammond, Vladimír Hampl, Geoff Horst, Takahiro Ishikawa, Anna Karnkowska, Eric W. Linton, Peter Myler, Masami Nakazawa, Pierre Cardol, Rosina Sánchez-Thomas, Barry J. Saville, Mahfuzur R. Shah, Alastair G. B. Simpson, Aakash Sur, Kengo Suzuki, Kevin M. Tyler, Paul V. Zimba, Neil Hall, Mark C. Field
Publikováno v:
Biology Open, Vol 11, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/e0facc962851463cabd18f2dab786d2e
Autor:
Maria J. R. Bezerra, Danielle M. N. Moura, Eden R. Freire, Fabiola B. Holetz, Christian R. S. Reis, Tallyta T. S. Monteiro, Adriana R. S. Pinto, Ning Zhang, Antonio M. Rezende, Antonio Pereira-Neves, Regina C. B. Q. Figueiredo, Christine Clayton, Mark C. Field, Mark Carrington, Osvaldo P. de Melo Neto
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and eIF4G subunits, is res
Externí odkaz:
https://doaj.org/article/209fd9a580714eabae65717513a48ea1
Autor:
Norma E. Padilla-Mejia, Alexandr A. Makarov, Lael D. Barlow, Erin R. Butterfield, Mark C. Field
Publikováno v:
Nucleus, Vol 12, Iss 1, Pp 21-41 (2021)
Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. The NE posses
Externí odkaz:
https://doaj.org/article/4a3870a6bf0c424cabaa72ea0254c73a
Autor:
Aarthi Kuppannan, Yu-Yang Jiang, Wolfgang Maier, Chang Liu, Charles F Lang, Chao-Yin Cheng, Mark C Field, Minglei Zhao, Martin Zoltner, Aaron P Turkewitz
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010194 (2022)
In the ciliate Tetrahymena thermophila, lysosome-related organelles called mucocysts accumulate at the cell periphery where they secrete their contents in response to extracellular events, a phenomenon called regulated exocytosis. The molecular bases
Externí odkaz:
https://doaj.org/article/64658e179f64424eb43c40327eb131f2
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 10, Pp 595-608 (2019)
Abstract Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated through endocytosis and the suramin receptor in
Externí odkaz:
https://doaj.org/article/a7b2b091b6b4464990b59f4c0bd9dc69