Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mark Broadwin"'
Autor:
Dwight D. Harris, MD, Sharif A. Sabe, MD, Mark Broadwin, MD, Christopher Stone, MD, Cynthia Xu, MD, Meghamsh Kanuparthy, MD, Akshay Malhotra, M. Ruhul Abid, MD, PhD, Frank W. Sellke, MD, FACS
Publikováno v:
JTCVS Open, Vol 20, Iss , Pp 49-63 (2024)
Objective: Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Patients with advanced coronary artery disease who are not eligible for endovascular or surgical revascularization have limited options. Extracellular ve
Externí odkaz:
https://doaj.org/article/5f4afdcb756649dca1e6ceb06d9b4d02
Autor:
Mohamed Sabra, MD, Sharif A. Sabe, MD, Dwight D. Harris, MD, Cynthia M. Xu, MD, Mark Broadwin, MD, Krishnah G. Bellam, BS, Debolina Banerjee, MD, M. Ruhul Abid, MD, PhD, Frank W. Sellke, MD
Publikováno v:
JTCVS Open, Vol 16, Iss , Pp 419-428 (2023)
Background: Coronary artery disease remains a leading cause of death worldwide. Bone mesenchymal stem cell–derived extracellular vesicles (EVs) have shown promise in the setting of myocardial ischemia. Furthermore, the properties of the EVs can be
Externí odkaz:
https://doaj.org/article/1abe4224b2784819a9eb84c47a031940
Autor:
Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Krishna Bellam, Cynthia M. Xu, Janelle W. Li, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Physiological Reports, Vol 12, Iss 5, Pp n/a-n/a (2024)
Abstract Small animal models have shown improved cardiac function with DPP‐4 inhibition, but many human studies have shown worse outcomes or no benefit. We seek to bridge the gap by studying the DPP‐4 inhibitor sitagliptin in a swine model of chr
Externí odkaz:
https://doaj.org/article/f27f84df195941149f8e675d33ffaaac
Autor:
Dwight D. Harris, MD, Sharif A. Sabe, MD, Mohamed Sabra, MD, Cynthia M. Xu, MD, Akshay Malhotra, Mark Broadwin, MD, Debolina Banerjee, MD, M. Ruhul Abid, MD, PhD, Frank W. Sellke, MD
Publikováno v:
JTCVS Open, Vol 15, Iss , Pp 220-228 (2023)
Objective: Limited treatments exist for nonoperative chronic coronary artery disease. Previously, our laboratory has investigated extracellular vesicle (EV) therapy as a potential treatment for chronic coronary artery disease using a swine model and
Externí odkaz:
https://doaj.org/article/38099fd14f5e4cf1bade6d4d8db6a084
Autor:
Dwight D Harris, Sharif A Sabe, Mark Broadwin, Chris Stone, Krishna Bellam, Akshay Malhotra, M Ruhul Abid, Frank W Sellke
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307922 (2024)
Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the underlying mechanisms remain unclear. We therefore sought to evaluate the effect of the DPP-4 inh
Externí odkaz:
https://doaj.org/article/96ce12eebdda43b0b8f06562ba6566f8
Autor:
Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, Krishna G. Bellam, Debolina Banerjee, Anny Usheva, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100052- (2023)
Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. The aim of this
Externí odkaz:
https://doaj.org/article/e9557c7c57a44d25bb14e0eb64c8f0f3
Autor:
Cynthia M. Xu, Catherine Karbasiafshar, Rayane Brinck‐Teixeira, Mark Broadwin, Frank W. Sellke, M. Ruhul Abid
Publikováno v:
Physiological Reports, Vol 11, Iss 24, Pp n/a-n/a (2023)
Abstract Human bone mesenchymal stem cell‐derived extracellular vesicles (HBMSC‐EV) have been used successfully in animal models of myocardial ischemia, yet have dampened effects in metabolic syndrome through unknown mechanisms. This study demons
Externí odkaz:
https://doaj.org/article/b2931ec8e60a4b42b95b2ed60482ae08
Autor:
Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Christopher Stone, Cynthia Xu, Jiayu Hu, Meghamsh Kanuparthy, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 588 (2024)
Background: Sodium–glucose cotransporter-2 (SGLT2) inhibitors are known to be cardioprotective independent of glucose control, but the mechanisms of these benefits are unclear. We previously demonstrated improved cardiac function and decreased fibr
Externí odkaz:
https://doaj.org/article/4051e228aea7497d957cae451312bb7c
Autor:
Mark Broadwin, Dwight D. Harris, Sharif A. Sabe, Elif Sengun, Amber J. Sylvestre, Boian S. Alexandrov, Frank W. Sellke, Anny Usheva
Publikováno v:
Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)
Abstract Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease. Unfortunately, effective prevention and long‐term treatment options remain limited. We d
Externí odkaz:
https://doaj.org/article/1ef5d5352a9a46db982db17c820b2f92
Autor:
Sharif A. Sabe, Dwight Douglas Harris, Mark Broadwin, Mohamed Sabra, Cynthia M. Xu, Debolina Banerjee, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Physiological Reports, Vol 11, Iss 11, Pp n/a-n/a (2023)
Abstract Dipeptidyl peptidase 4 inhibitors (DPP4i) may be cardioprotective based on several small animal and clinical studies, though randomized control trials have demonstrated limited benefit. Given these discrepant findings, the role of these agen
Externí odkaz:
https://doaj.org/article/d6badc10ff1d4b0a897d7849694739eb