Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Mark Boldin"'
Autor:
Zheng Zhang, Keren Zhou, Li Han, Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 382-396 (2024)
As the most common internal modification of mRNA, N6-methyladenosine (m6A) and its regulators modulate gene expression and play critical roles in various biological and pathological processes including tumorigenesis. It was reported previously that m
Externí odkaz:
https://doaj.org/article/bd64f8356dfc4a9a8e981d1b56e09447
Autor:
Bin Zhang, Dandan Zhao, Fang Chen, David Frankhouser, Huafeng Wang, Khyatiben V. Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang, Min-Hsuan Chen, Shu Tao, Hyejin Cho, Yong Liang, Danilo Perrotti, Sergio Branciamore, Russell Rockne, Xiwei Wu, Lucy Ghoda, Ling Li, Jie Jin, Jianjun Chen, Jianhua Yu, Michael A. Caligiuri, Ya-Huei Kuo, Mark Boldin, Rui Su, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34+CD38− blasts from BC CML patients than in t
Externí odkaz:
https://doaj.org/article/883dc5faaf3c4abe8121ce71d3dc31ce
Autor:
Jeffrey Lam, Marion van den Bosch, Joanna Wegrzyn, Jeremy Parker, Rawa Ibrahim, Kate Slowski, Linda Chang, Sergio Martinez-Høyer, Gianluigi Condorelli, Mark Boldin, Yu Deng, Patricia Umlandt, Megan Fuller, Aly Karsan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Myelodysplastic syndrome (MDS) is characterized by altered hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation and reduction of miR-143 and miR-145 in some subtypes. Here the authors show that miR-143/145 loss leads to HS
Externí odkaz:
https://doaj.org/article/790c5842cee2493c94acd0bef130e50e
Autor:
Zheng Zhang, Keren Zhou, Li Han, Andrew Small, Jianhuang Xue, Huilin Huang, Hengyou Weng, Rui Su, Brandon Tan, Chao Shen, Wei Li, Zhicong Zhao, Ying Qing, Xi Qin, Kitty Wang, Keith Leung, Mark Boldin, Chun-Wei Chen, David Ann, Zhijian Qian, Xiaolan Deng, Jianjun Chen, Zhenhua Chen
Publikováno v:
Genes & Diseases.
Publikováno v:
BMC Neuroscience, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Visual perception of X-radiation is a well-documented, but poorly understood phenomenon. Scotopic rod cells and rhodopsin have been implicated in visual responses to X-rays, however, some evidence suggests that X-rays excite the retina via a
Externí odkaz:
https://doaj.org/article/f4050f700cf14fe19decd935a4b98208
Autor:
Aparna Gopal, Megan Fuller, Yu Deng, Mark Boldin, Jennifer M Grants, Aly Karsan, Joanna Wegrzyn, David J.H.F. Knapp, Connie J. Eaves, T. Roderick Docking, Tony Hui, Jenny Li, Marion Shadbolt, Kieran O'Neill, Jeremy Parker, Martin Hirst
Publikováno v:
Blood
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignancy. Inflammation of aging (“inflammaging”) has
Autor:
Grazyna Bochenek, Egon Urgard, Sebastian L. Johnston, Alan Altraja, Anet Laanesoo, Ana Rebane, Kapilraj Periyasamy, Mark Boldin, Alar Aab, Martti Laan, Jesper Wengel, Margus Pooga, Yury A. Bochkov, Bogdan Jakiela, James E. Gern, Jonathan M. Coquet, Nathaniel Magilnick
Publikováno v:
Clinical and Translational Medicine
Laanesoo, A, Urgard, E, Periyasamy, K, Laan, M, Bochkov, Y A, Aab, A, Magilnick, N, Pooga, M, Gern, J E, Johnston, S L, Coquet, J M, Boldin, M P, Wengel, J, Altraja, A, Bochenek, G, Jakiela, B & Rebane, A 2021, ' Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation ', Clinical and Translational Medicine, vol. 11, no. 6, e427 . https://doi.org/10.1002/ctm2.427
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Laanesoo, A, Urgard, E, Periyasamy, K, Laan, M, Bochkov, Y A, Aab, A, Magilnick, N, Pooga, M, Gern, J E, Johnston, S L, Coquet, J M, Boldin, M P, Wengel, J, Altraja, A, Bochenek, G, Jakiela, B & Rebane, A 2021, ' Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation ', Clinical and Translational Medicine, vol. 11, no. 6, e427 . https://doi.org/10.1002/ctm2.427
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Rhinovirus (RV) infections are associated with asthma exacerbations. MicroRNA‐146a and microRNA‐146b (miR‐146a/b) are anti‐inflammatory miRNAs that suppress signaling through the nuclear factor kappa B (NF‐κB) pathway and inhibit pro‐inf
Autor:
Richard Stange, Gerwin Heller, Matthias Hackl, Gernot Schabbauer, Mark Boldin, Victoria Saferding, Guenter Steiner, S Blueml, Johannes Grillari, Moritz Weigl, Nathaniel Magilnick, Josef S Smolen, Melanie Hofmann, Melanie Timmen, Julia S. Brunner, Silvia Hayer, Birgit Niederreiter
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here we identify microRNA 146a as an essential e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3365bd98ec81f6c99365b39bce803774
https://doi.org/10.1101/2020.03.20.000174
https://doi.org/10.1101/2020.03.20.000174
Autor:
Xiuli Wang, Zhuoran Zhang, Mark Boldin, Ching Ouyang, Yu-Lin Su, Guido Marcucci, Bin Zhang, Stephen J. Forman, David Baltimore, Dayson Moreira, Mati Mann, Ling Li, Dongfang Wang, Marcin Kortylewski, Tomasz Adamus, Piotr Swiderski, Xin He
NF-κB is a key regulator of inflammation and cancer progression, with an important role in leukemogenesis. Despite its therapeutic potential, targeting NF-κB using pharmacologic inhibitors has proven challenging. Here, we describe a myeloid cell–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb141c1901c2c5318bfb01dfbf216692
https://resolver.caltech.edu/CaltechAUTHORS:20191218-082734179
https://resolver.caltech.edu/CaltechAUTHORS:20191218-082734179
Autor:
Mark Boldin, Linda Chang, Gianluigi Condorelli, Joanna Wegrzyn, Megan Fuller, Jeffrey C. F. Lam, Sergio Martinez-Høyer, Marion van den Bosch, Jeremy Parker, Yu Deng, Kate Slowski, Rawa Ibrahim, Patricia Umlandt, Aly Karsan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Expression of miR-143 and miR-145 is reduced in hematopoietic stem/progenitor cells (HSPCs) of myelodysplastic syndrome patients with a deletion in the long arm of chromosome 5. Here we show that mice lacking miR-143/145 have impaired HSPC activity w