Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Mark Bates"'
Autor:
Joanna Lazniewska, Ka Lok Li, Ian R. D. Johnson, Alexandra Sorvina, Jessica M. Logan, Carmela Martini, Courtney Moore, Ben S.-Y. Ung, Litsa Karageorgos, Shane M. Hickey, Sarita Prabhakaran, Jessica K. Heatlie, Robert D. Brooks, Chelsea Huzzell, Nicholas I. Warnock, Mark P. Ward, Bashir Mohammed, Prerna Tewari, Cara Martin, Sharon O’Toole, Laura Bogue Edgerton, Mark Bates, Paul Moretti, Stuart M. Pitson, Stavros Selemidis, Lisa M. Butler, John J. O’Leary, Douglas A. Brooks
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling. Defining the molecular mechanism that underpins this m
Externí odkaz:
https://doaj.org/article/50253ef611194e4595e03d647adf9305
Autor:
Tanya E. Kelly, Cathy L. Spillane, Mark P. Ward, Karsten Hokamp, Yanmei Huang, Prerna Tewari, Cara M. Martin, Lucy A. Norris, Bashir M. Mohamed, Mark Bates, Robert Brooks, Stavros Selemidis, Douglas A. Brooks, Waseem Kamran, Feras Abu Saadeh, Sharon A. O’Toole, John J. O’Leary
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian cancer (EOC), killing over 140,000 people annually. Morbidity and mortality are compounded by a lack of screening methods, and re
Externí odkaz:
https://doaj.org/article/33bd691aaea5495980163d42d2344d28
Autor:
Bashir M. Mohamed, Mark P. Ward, Mark Bates, Cathy D. Spillane, Tanya Kelly, Cara Martin, Michael Gallagher, Sheena Heffernan, Lucy Norris, John Kennedy, Feras Abu Saadeh, Noreen Gleeson, Doug A. Brooks, Robert D. Brooks, Stavros Selemidis, Sharon O’Toole, John J. O’Leary
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability of CTC isolation/purification has limited both the potential to report on metastatic progression and the development of CTC
Externí odkaz:
https://doaj.org/article/8a0eceb23e854e889f86fef99c3b1ed3
Autor:
Hamidreza Heydarian, Maarten Joosten, Adrian Przybylski, Florian Schueder, Ralf Jungmann, Ben van Werkhoven, Jan Keller-Findeisen, Jonas Ries, Sjoerd Stallinga, Mark Bates, Bernd Rieger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Adaptation of current algorithms to 3D SMLM data is currently problematic. Here the authors report a method that increases the signal-to-noise ratio and resolution of 3D single particle analysis in localization microscopy and enables determination of
Externí odkaz:
https://doaj.org/article/d17ad19811dd4f2a9819d5862675ea69
Autor:
Mark P. Ward, Laura E. Kane, Lucy A. Norris, Bashir M. Mohamed, Tanya Kelly, Mark Bates, Andres Clarke, Nathan Brady, Cara M. Martin, Robert D. Brooks, Doug A. Brooks, Stavros Selemidis, Sean Hanniffy, Eric P. Dixon, Sharon A. O’Toole, John J. O’Leary
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Cancer cells that transit from primary tumours into the circulatory system are known as circulating tumour cells (CTCs). These cancer cells have unique phenotypic and genotypic characteristics which allow them to survive within the circulati
Externí odkaz:
https://doaj.org/article/6c9b855579b040d7a4a07c53dfa5ef3f
Autor:
Roshni D. Kalachand, Ciaran O’Riain, Sinead Toomey, Aoife Carr, Kirsten M. Timms, Sharon O’Toole, Stephen Madden, Mark Bates, John J. O’Leary, Noreen Gleeson, Dearbhaile O’Donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T. Hennessy
Publikováno v:
Obstetrics & Gynecology Science, Vol 63, Iss 5, Pp 643-654 (2020)
Objective The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mut
Externí odkaz:
https://doaj.org/article/6cbb4fc095ea435da4eec3de790092e5
Autor:
Ruchi Bhandari, Talia Alexander, Frank H Annie, Umar Kaleem, Affan Irfan, Sudarshan Balla, R Constance Wiener, Chris Cook, Aravinda Nanjundappa, Mark Bates, Ellen Thompson, Gordon S Smith, Judith Feinberg, Melanie A Fisher
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271510 (2022)
IntroductionLife-threatening infections such as infective endocarditis (IE) are increasing simultaneously with the injection drug use epidemic in West Virginia (WV). We utilized a newly developed, statewide database to describe epidemiologic characte
Externí odkaz:
https://doaj.org/article/c09b2fc573554422841ec6230333334b
Autor:
Cathy D. Spillane, Niamh M. Cooke, Mark P. Ward, Dermot Kenny, Gordon Blackshields, Tanya Kelly, Mark Bates, Yanmei Huang, Cara Martin, Sinead Skehan, Aoife Canney, Michael Gallagher, Paul Smyth, Nathan Brady, Andres Clarke, Bashir Mohamed, Lucy Norris, Doug A. Brooks, Robert D. Brooks, Jessica K. Heatlie, Stavros Selemidis, Sean Hanniffy, Eric Dixon, Orla Sheils, Sharon A. O'Toole, John J. O'Leary
Publikováno v:
Translational Oncology, Vol 14, Iss 12, Pp 101229- (2021)
Tumour metastasis accounts for over 90% of cancer related deaths. The platelet is a key blood component, which facilitates efficient metastasis. This study aimed to understand the molecular mechanisms involved in tumour-platelet cell interactions.The
Externí odkaz:
https://doaj.org/article/96006004b9d1476db6b67d42f80f41fd
Autor:
Sam D Hutchings, Jim Watchorn, Rory McDonald, Su Jeffreys, Mark Bates, Sarah Watts, Emrys Kirkman
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261546 (2021)
IntroductionHaemorrhage is a leading cause of death following traumatic injury and the early detection of hypovolaemia is critical to effective management. However, accurate assessment of circulating blood volume is challenging when using traditional
Externí odkaz:
https://doaj.org/article/c5ce67c53e754084b3c046a1ac70bcd4
Autor:
Mark Bates, Cathy D Spillane, Michael F Gallagher, Amanda McCann, Cara Martin, Gordon Blackshields, Helen Keegan, Luke Gubbins, Robert Brooks, Doug Brooks, Stavros Selemidis, Sharon O'Toole, John J O'Leary
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243715 (2020)
Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients will develop recurrent chemoresistant disease which
Externí odkaz:
https://doaj.org/article/1b4173fb417c4b46a697ca0c7cfb267a