Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Mark Barnes"'
Autor:
Azhar Khandekar, Raviteja Vangara, Mark Barnes, Marcos Díaz-Gay, Ammal Abbasi, Erik N. Bergstrom, Christopher D. Steele, Nischalan Pillay, Ludmil B. Alexandrov
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background All cancers harbor somatic mutations in their genomes. In principle, mutations affecting between one and fifty base pairs are generally classified as small mutational events. Conversely, large mutational events affect more than fi
Externí odkaz:
https://doaj.org/article/e277fb79cb7e4bdb8efd3acb49845605
Autor:
Burçak Otlu, Marcos Díaz-Gay, Ian Vermes, Erik N. Bergstrom, Maria Zhivagui, Mark Barnes, Ludmil B. Alexandrov
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112930- (2023)
Summary: The somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can be affected by the genome architecture. However, the interplay between mut
Externí odkaz:
https://doaj.org/article/2bad3d2278f34f4d858be7fc84bbc8cd
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Performing a statistical test requires a null hypothesis. In cancer genomics, a key challenge is the fast generation of accurate somatic mutational landscapes that can be used as a realistic null hypothesis for making biological d
Externí odkaz:
https://doaj.org/article/607653a1f6194867833f277b9264359a
SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events
Autor:
Erik N. Bergstrom, Mi Ni Huang, Uma Mahto, Mark Barnes, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Cancer genomes are peppered with somatic mutations imprinted by different mutational processes. The mutational pattern of a cancer genome can be used to identify and understand the etiology of the underlying mutational processes.
Externí odkaz:
https://doaj.org/article/15d692f5dc384868a0328f08ea0f4215
Publikováno v:
Journal of Bone Oncology, Vol 4, Iss 4, Pp 107-109 (2015)
Purpose: This study assesses the incidence of distal bone metastases in palliative radiotherapy (RT) patients. Material and methods: All courses of RT for bone metastases from 2007–2011 for patient living in British Columbia (BC) were identified in
Externí odkaz:
https://doaj.org/article/b61a1805462a40ea9aab0380337b9b9a
Autor:
Dr Ranjeeta Thomas, PhD, Ronelle Burger, PhD, Abigail Harper, MSc, Sarah Kanema, BSc, Lawrence Mwenge, MSc, Nosivuyile Vanqa, MPhil, Nomtha Bell-Mandla, MPH, Prof Peter C Smith, MSc, Sian Floyd, MSc, Peter Bock, MRCPUK, Helen Ayles, PhD, Prof Nulda Beyers, PhD, Deborah Donnell, PhD, Sarah Fidler, PhD, Prof Richard Hayes, DSc, Katharina Hauck, PhD, James Hargreaves, Deborah Watson-Jones, Peter Godfrey-Faussett, Anne Cori, Mike Pickles, Nomtha Mandla, Blia Yang, Anelet James, Redwaan Vermaak, Nozizwe Makola, Graeme Hoddinott, Vikesh Naidoo, Virginia Bond, Musonda Simwinga, Alwyn Mwinga, Barry Kosloff, Mohammed Limbada, Justin Bwalya, Chepela Ngulube, Christophe Fraser, Susan Eshleman, Yaw Agyei, Vanessa Cummings, Denni Catalano, Lynda Emel, Lisa Bunts, Heather Noble, David Burns, Alain Kouda, Niru Sista, Ayana Moore, Rhonda White, Tanette Headen, Eric Miller, Kathy Hinson, Sten Vermund, Mark Barnes, Lyn Horn, Albert Mwango, Megan Baldwin, Shauna Wolf, Erin Hughes
Publikováno v:
The Lancet Global Health, Vol 5, Iss 11, Pp e1133-e1141 (2017)
Background: The life expectancy of HIV-positive individuals receiving antiretroviral therapy (ART) is approaching that of HIV-negative people. However, little is known about how these populations compare in terms of health-related quality of life (HR
Externí odkaz:
https://doaj.org/article/5e13a828ee5a49eaa7431d4f97d6547c
Autor:
Donna Hanrahan, Patrina Sexton, Katrina Hui, Jennifer Teitcher, Jeremy Sugarman, Alex John London, Mark Barnes, James Purpura, Robert Klitzman
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133394 (2015)
Linguistic and cultural differences can impede comprehension among potential research participants during the informed consent process, but how researchers and IRBs respond to these challenges in practice is unclear. We conducted in-depth interviews
Externí odkaz:
https://doaj.org/article/5b2a02a687c140a1b77daec2dd574164
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91585 (2014)
Studies on Coding Region Determinant-Binding Protein (CRD-BP) and its orthologs have confirmed their functional role in mRNA stability and localization. CRD-BP is present in extremely low levels in normal adult tissues, but it is over-expressed in ma
Externí odkaz:
https://doaj.org/article/77535403bb1a41d9b0fc94dabef35743
Autor:
Mark Barnes
Publikováno v:
North American Archaeologist. 43:230-248
The Paso del Indio site, discovered and partially mitigated in the midst of a major highway construction project, is the largest and deepest stratified, multi-component prehistoric site found to date on the island of Puerto Rico, and likely the entir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e227fad8c16367d946257aeb73cea9
https://doi.org/10.1177/01976931221102981
https://doi.org/10.1177/01976931221102981
Autor:
Erik N. Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Tongwu Zhang, Christopher D. Steele, Nischalan Pillay, Maria Teresa Landi, Vineet Bafna, Paul S. Mischel, Reuben S. Harris, Ludmil B. Alexandrov
Publikováno v:
Nature. 602:510-517
Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c67f65fea310de64ce9bb584e5ddde2
https://doi.org/10.1038/s41586-022-04398-6
https://doi.org/10.1038/s41586-022-04398-6