Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark B. Willey"'
Autor:
Ming Dauh Wang, H. Bryan Brewer, Stephen J. Nicholls, Mark A. Deeg, Giacomo Ruotolo, Liping Liu, Mark B. Willey, Steven E. Nissen, Kathryn A. Krueger
Publikováno v:
Journal of clinical lipidology. 10(3)
Background Potent CETP inhibitors reduce plasma concentrations of atherogenic lipoprotein biomarkers of cardiovascular risk. Objectives To evaluate the effects of the cholesteryl ester transfer protein (CETP) inhibitor evacetrapib, as monotherapy or
Autor:
Ian Gourley, Viswanath Devanarayan, Peter J. O'Brien, Carmen M. Dumaual, Mark B. Willey, Chad Ray, Jeffrey Fill, Robert J. Konrad
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 41:189-195
Purpose Measurements of cytokine release in whole blood after ex vivo stimulation are useful in drug development. The components contributing to variation within such assays have not been clearly defined. Therefore, we characterized the sources of va
Autor:
J. Michael Taylor, Mark B. Willey, John T. Brandt, Robert J. Konrad, Thomas N. Lee, James S. Bourdage
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 39:685-690
The double antigen bridging immunoassay has been used extensively for detection of immunogenicity responses to therapeutic monoclonal antibodies. We have analyzed parameters affecting performance of this type of immunoassay including microtiter plate
Autor:
Chad Ray, Robert A. Dean, Mark B. Willey, Wendell C. Smith, Viswanath Devanarayan, Ronald R. Bowsher, John T. Brandt
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:1037-1044
Quantification of biomarkers can provide important information about the safety and efficacy of candidate drugs. Unfortunately, limited sample volume and excess costs often limit analysis of multiple biomarkers. We developed, optimized, validated, an
Autor:
Jason S. Troutt, Yue-Wei Qian, Robert J. Konrad, Xiliang Wang, Guoqing Cao, Mariam Ehsani, William E. Alborn, John H. Sloan, Karen Leigh Cox, Melissa A. Bellinger, Mark B. Willey
Publikováno v:
Lipids. 45(8)
ATP-binding cassette transporter A-1 (ABCA1) mediates the transfer of cellular cholesterol to lipid-poor apolipoproteins. Liver X receptors (LXRs) are regulators of cholesterol homeostasis that increase transcription of ABCA1. Synthetic LXR agonists
Autor:
G. de Meyer, David Richard Lachno, Hugo Vanderstichele, Mark B. Willey, G. De Groote, Vesna Kostanjevecki, Robert J. Konrad, Eric Siemers, James S. Bourdage, Robert A. Dean
Publikováno v:
The journal of nutrition, healthaging. 13(3)
The aim of the study was to determine the extent to which plasma matrix types, diurnal rhythm and sample collection and processing procedures contribute to overall variability of measurements with the INNO-BIA plasma Abeta forms assay.Plasma samples
Autor:
Mark B. Willey, Robert J. Konrad, Robert J. White, William E. Alborn, Bradley L. Ackermann, Richard M. LeLacheur, Barry S. Lutzke, George Stavrakis
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 48(5)
Recent studies have shown a correlation between 5-lipoxygenase (5-LO) pathway up-regulation and cardiovascular risk. Despite the existence of several assays for products of the 5-LO pathway, a reliable method for clinical determination of 5-LO activi