Výsledky vyhledávání - "Mark B. Stoddard"

Akademický článek

Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4

Autor: Mark B. Stoddard, Hui Li, Shuyi Wang, Mohsan Saeed, Linda Andrus, Wenge Ding, Xinpei Jiang, Gerald H. Learn, Markus von Schaewen, Jessica Wen, Paul A. Goepfert, Beatrice H. Hahn, Alexander Ploss, Charles M. Rice, George M. Shaw

Publikováno v: mBio, Vol 6, Iss 2 (2015)

ABSTRACT Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a “quasispecies.” Transmission is generally associated with a stringent population bottleneck characterized by infection

Externí odkaz: https://doaj.org/article/8b5e61bca3f945b18a7dd2612c61c17d

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Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length

Autor: George M. Shaw, Michael Gale, Alison M. Kell, Joe Marcotrigiano, Mark B. Stoddard, Hui Li

Publikováno v: Journal of Virology

Despite the introduction of direct-acting antiviral (DAA) drugs against hepatitis C virus (HCV), infection remains a major public health concern because DAA therapeutics do not prevent reinfection and patients can still progress to chronic liver dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674a73dab840fa0fa3662d976a86be89
https://doi.org/10.1128/jvi.01964-15

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A phase 1 study of a group B meningococcal native outer membrane vesicle vaccine made from a strain with deleted lpxL2 and synX and stable expression of opcA

Autor: Valerian B. Pinto, Paul B. Keiser, Mark B. Stoddard, Ping Chen, Wendell D. Zollinger, Joseph E. Labrie, Deborah H. Schmiel, E. E. Moran, Trinka S. Coster, Barnett Gibbs

Publikováno v: Vaccine. 28:6970-6976

This phase 1 clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from a lpxL2(-) synX(-) mutant of strain 44/76 with opcA expression stabilized. Thirty-four volunteers were assigned to one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074262d6db3881b7aca66152f68a3a8d
https://doi.org/10.1016/j.vaccine.2010.08.048

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Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccine

Autor: Elizabeth E. Moran, Mikhail A. Donets, Paul B. Keiser, Ryan Marques, Valerian B. Pinto, Ping Chen, Deborah H. Schmiel, Boris Ionin, Brenda L. Brandt, Wendell D. Zollinger, Max T Wu, Mark B. Stoddard, Joseph E. Labrie

Publikováno v: Vaccine. 28:5057-5067

A vaccine based on native outer membrane vesicles (NOMV) that has potential to provide safe, broad based protection against group B strains of Neisseria meningitidis has been developed. Three antigenically diverse group B strains of N. meningitidis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ca98686e2c8e3bf469343d7d03a700
https://doi.org/10.1016/j.vaccine.2010.05.006

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Evaluation of a Whole-Blood Cytokine Release Assay for Use in Measuring Endotoxin Activity of Group B Neisseria meningitidis Vaccines Made from Lipid A Acylation Mutants

Autor: Valerian B. Pinto, Mark B. Stoddard, Wendell D. Zollinger, Paul B. Keiser

Publikováno v: Clinical and Vaccine Immunology. 17:98-107

Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2487997fe9dfc2494144a88903f2e25d
https://doi.org/10.1128/cvi.00342-09

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Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification

Autor: Beatrice H. Hahn, Mark B. Stoddard, Daniel S. Fierer, Hui Li, Tanmoy Bhattacharya, Harvey J. Alter, George M. Shaw, Gerald H. Learn, Shuyi Wang, Ruy M. Ribeiro, Alan S. Perelson, Lily M. Blair, Elena E. Giorgi, Michael P. Busch

Publikováno v: Journal of Virology

Despite the recent development of highly effective anti-hepatitis C virus (HCV) drugs, the global burden of this pathogen remains immense. Control or eradication of HCV will likely require the broad application of antiviral drugs and development of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb1a165d95ef30bafbc9a7426cbb63f
https://pubmed.ncbi.nlm.nih.gov/26468546

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Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4

Autor: Shuyi Wang, George M. Shaw, Gerald H. Learn, Charles M. Rice, Paul A. Goepfert, Hui Li, Mohsan Saeed, Xinpei Jiang, Alexander Ploss, Markus von Schaewen, Wenge Ding, Linda Andrus, Jessica Wen, Beatrice H. Hahn, Mark B. Stoddard

Publikováno v: mBio, Vol 6, Iss 2 (2015)
mBio

Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a “quasispecies.” Transmission is generally associated with a stringent population bottleneck characterized by infection by limite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4307ecc2339faf5e5b51de0831f39941
https://doi.org/10.1128/mbio.02518-14

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Transmitted/Founder Hepatitis C Viruses Induce Cell-Type- and Genotype-Specific Differences in Innate Signaling within the Liver

Autor: Hui Li, Mark B. Stoddard, Michael G. Edwards, Lucy Golden-Mason, Salman R. Khetani, Angela M. Mitchell, Hugo R. Rosen, Amy E. L. Stone, George M. Shaw, Linling Cheng, Kimberly R. Ballinger

Publikováno v: mBio, Vol 6, Iss 2 (2015)
mBio

Hepatitis C virus (HCV) infection leads to persistence in the majority of cases despite triggering complex innate immune responses within the liver. Although hepatocytes are the preferred site for HCV replication, nonparenchymal cells (NPCs) can also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db02ebad79fbcc3b168a6ba4a0023d59
https://journals.asm.org/doi/10.1128/mBio.02510-14

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Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

Autor: Shuyi Wang, Tanmoy Bhattacharya, Hui Li, Ruy M. Ribeiro, George M. Shaw, Jeremie Guedj, Beatrice H. Hahn, Mark B. Stoddard, Gerald H. Learn, Alan S. Perelson, Erica H. Parrish, Bette T. Korber

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 8, p e1002881 (2012)

Hepatitis C virus (HCV) is present in the host with multiple variants generated by its error prone RNA-dependent RNA polymerase. Little is known about the initial viral diversification and the viral life cycle processes that influence diversity. We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d701821d45c472d5b0b194e2cb4df
http://europepmc.org/articles/PMC3426522

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