Výsledky vyhledávání - "Mark B. Frenkel"

Akademický článek

Fungal Contamination of Methylprednisolone Causing Recurrent Lumbosacral Intradural Abscess

Autor: Jaclyn J. Renfrow, Mark B. Frenkel, Wesley Hsu

Publikováno v: Emerging Infectious Diseases, Vol 23, Iss 3, Pp 552-553 (2017)

Fungal meningitis transmitted through injections of methylprednisolone contaminated with Exserohilum rostratum affected 753 persons and caused 61 deaths in the United States in 2012. We report a case of infection recurrence after 24-months with the u

Externí odkaz: https://doaj.org/article/abaf054d5a1c494bbd6f7fe96a26d36f

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Gray-Scale Sonography of the Spinal Cord in Postlaminectomy Patient

Autor: Pallavi Juneja, Sam P. Carmichael, Aarti Sarwal, Mark B. Frenkel

Publikováno v: Journal of Diagnostic Medical Sonography. 37:200-205

Laminectomy, a common neurosurgical procedure that decompresses the spinal cord, is the definitive surgical treatment for spinal epidural abscesses. Although complications after laminectomy occur infrequently, they can cause significant morbidity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42deef414d7d9418b7054f4b03c4c20e
https://doi.org/10.1177/8756479320972099

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Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor

Autor: Gregory A. Hawkins, Shakti H. Ramkissoon, Roy E. Strowd, Jann N. Sarkaria, Carol Kittel, Ryan T. Mott, Waldemar Debinski, Stephanie Sanders, Michael H. Soike, Jaclyn J. Renfrow, James L. West, Denise Herpai, Linda J. Metheny-Barlow, Stephen B. Tatter, Ralph B. D'Agostino, Adrian W. Laxton, Glenn J. Lesser, Mark B. Frenkel

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

Hypoxia inducible factor (HIFs) signaling contributes to malignant cell behavior in glioblastoma (GBM). We investigated a novel HIF2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb081f4c78c4dbfdfb4f06c13bf9ca27
http://link.springer.com/article/10.1038/s41598-020-72290-2

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Craniocervical Osteoradionecrosis Treated with Neoadjuvant and Adjuvant Hyperbaric Oxygen in Combination with Posterior Spinal Fusion

Autor: Jaclyn J. Renfrow, James L West, John A. Wilson, Mark B. Frenkel

Publikováno v: World Neurosurgery. 126:107-112

Background Radiation therapy for malignant head and neck cancers includes a risk for off-target effects to bony structures, posing a risk for osteoradionecrosis (ORN). Patients in whom ORN develops can also harbor concomitant osteomyelitis and reduce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcf85ad78207b203d60fd4989a8ec10
https://doi.org/10.1016/j.wneu.2019.02.177

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Hypoxia-inducible factor 2α: a novel target in gliomas

Autor: Jann N. Sarkaria, Jaclyn J. Renfrow, Shakti H. Ramkissoon, Waldemar Debinski, Mark B. Frenkel, Michael H. Soike, Roy E. Strowd, Glenn J. Lesser, Ryan T. Mott

Publikováno v: Future Medicinal Chemistry. 10:2227-2236

Hypoxia is an important contributor to aggressive behavior and resistance mechanisms in glioblastoma. Upregulation of hypoxia inducible transcription factors (HIFs) is the primary adaptive cellular response to a hypoxic environment. While HIF1α has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b6a42d8457148c27b684c568a2d425
https://doi.org/10.4155/fmc-2018-0163

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