Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mark B, Vestergaard"'
Autor:
Christian Sandøe Musaeus, Troels Wesenberg Kjaer, Ulrich Lindberg, Mark B. Vestergaard, Henrik Bo, Wiberg Larsson, Daniel Zvi Press, Birgitte Bo Andersen, Peter Høgh, Preben Kidmose, Martin Christian Hemmsen, Mike Lind Rank, Steen Gregers Hasselbalch, Gunhild Waldemar, Kristian Steen Frederiksen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discharges and a study us
Externí odkaz:
https://doaj.org/article/717fb5de537b4cd4a7d4693bec1aff98
Autor:
Mark B. Vestergaard, Jens Christian Laursen, Niels Søndergaard Heinrich, Peter Rossing, Tine Willum Hansen, Henrik B. W. Larsson
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionPatients with type 1 diabetes (T1D) demonstrate brain alterations, including white matter lesions and cerebral atrophy. In this case–control study, we investigated if a reason for this atrophy could be because of diabetes-related compli
Externí odkaz:
https://doaj.org/article/95b55858919c457d94d67fcb3e2f64b0
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The inflammatory processes observed in the central nervous system in multiple sclerosis (MS) could damage the endothelium of the cerebral vessels and lead to a dysfunctional regulation of vessel tonus and recruitment, potentially impairing cerebrovas
Externí odkaz:
https://doaj.org/article/bb9dcd30095b478182a707bbd0739262
Autor:
Mark B. Vestergaard, Oriol P. Calvo, Adam E. Hansen, Sverre Rosenbaum, Henrik B.W. Larsson, Otto M. Henriksen, Ian Law
Publikováno v:
NeuroImage, Vol 233, Iss , Pp 117950- (2021)
In present study we aimed to validate the use of image-derived input functions (IDIF) in the kinetic modeling of cerebral blood flow (CBF) measured by [15O]H2O PET by comparing with the accepted reference standard arterial input function (AIF). Addit
Externí odkaz:
https://doaj.org/article/3efa54e8ffbb4cbda6465ab025fa4f5f
Autor:
Samaira Younis, Anders Hougaard, Casper E. Christensen, Mark B. Vestergaard, Olaf B. Paulson, Henrik B.W. Larsson, Messoud Ashina
Publikováno v:
NeuroImage: Clinical, Vol 32, Iss , Pp 102824- (2021)
In the pons, glutamatergic mechanisms are involved in regulating inhibitory descending pain modulation, serotoninergic neurotransmission as well as modulating the sensory transmission of the trigeminovascular system. Migraine involves altered pontine
Externí odkaz:
https://doaj.org/article/4c81da640f0146dabc7584f24207bf63
Autor:
Samaira Younis, Anders Hougaard, Casper E. Christensen, Mark B. Vestergaard, Esben T. Petersen, Vincent O. Boer, Olaf B. Paulson, Messoud Ashina, Anouk Marsman, Henrik B. W. Larsson
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Glutamate detection in pons and thalamus using proton magnetic resonance spectroscopy (1H-MRS) after an intervention is of interest for studying various brain disorders. However, 1H-MRS in these brain regions is challenging and time-consuming, especi
Externí odkaz:
https://doaj.org/article/e7ed4c8bc54a4873844e15ff4a6576f9
Autor:
Mark B Vestergaard, Helle K Iversen, Sofie Amalie Simonsen, Ulrich Lindberg, Stig P Cramer, Ulrik B Andersen, Henrik BW Larsson
Publikováno v:
Vestergaard, M B, Iversen, H K, Simonsen, S A, Lindberg, U, Cramer, S P, Andersen, U B & Larsson, H B W 2023, ' Capillary transit time heterogeneity inhibits cerebral oxygen metabolism in patients with reduced cerebrovascular reserve capacity from steno-occlusive disease ', Journal of Cerebral Blood Flow and Metabolism, vol. 43, no. 3, pp. 460-475 . https://doi.org/10.1177/0271678X221139084
The healthy cerebral perfusion demonstrates a homogenous distribution of capillary transit times. A disruption of this homogeneity may inhibit the extraction of oxygen. A high degree of capillary transit time heterogeneity (CTH) describes that some c
Autor:
Abd R A Ismaili, Mark B Vestergaard, Adam E Hansen, Henrik B W Larsson, Helle H Johannesen, Ian Law, Otto M Henriksen
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197807 (2018)
PURPOSE:The aim of the study was to investigate the components of day-to-day variability of repeated phase contrast mapping (PCM) magnetic resonance imaging measurements of global cerebral blood flow (gCBF). MATERIALS AND METHODS:Two dataset were ana
Externí odkaz:
https://doaj.org/article/91c4a425f3824e4f921fe2aba3f519a1
Autor:
Aftab Bakhtiari, Mark B. Vestergaard, Krisztina Benedek, Birgitte Fagerlund, Erik Lykke Mortensen, Merete Osler, Martin Lauritzen, Henrik B. W. Larsson, Ulrich Lindberg
Publikováno v:
Bakhtiari, A, Vestergaard, M B, Benedek, K, Fagerlund, B, Mortensen, E L, Osler, M, Lauritzen, M, Larsson, H B W & Lindberg, U 2023, ' Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men ', GeroScience, vol. 45, pp. 1161–1175 . https://doi.org/10.1007/s11357-022-00712-2
Hippocampal blood–brain barrier (BBB) permeability may increase in normal healthy ageing and contribute to neurodegenerative disease. To examine this hypothesis, we investigated the correlation between blood–brain barrier (BBB) permeability, regi
Autor:
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Publikováno v:
Journal of magnetic resonance imaging : JMRIREFERENCES.
Dynamic contrast-enhanced MRI (DCE-MRI) has seen increasing use for quantification of low level of blood-brain barrier (BBB) leakage in various pathological disease states and correlations with clinical outcomes. However, currently there exists limit