Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Mark B, Pepys"'
Autor:
A. Floriaan Schmidt, Chris Finan, Sandesh Chopade, Stephan Ellmerich, Martin N. Rossor, Aroon D. Hingorani, Mark B. Pepys
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and al
Externí odkaz:
https://doaj.org/article/7b7fa5020a354c8684a1fb1ebee1aca7
Publikováno v:
Open Biology, Vol 13, Iss 12 (2023)
The mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are poorly understood. The normal plasma protein, serum amyloid P component (SAP), which is normally rigorously excluded from the brain, is directly neurocytotoxic f
Externí odkaz:
https://doaj.org/article/7091460bda894d59b4dd0f7551b04262
Autor:
Ivana Slamova, Rozita Adib, Stephan Ellmerich, Michal R. Golos, Janet A. Gilbertson, Nicola Botcher, Diana Canetti, Graham W. Taylor, Nigel Rendell, Glenys A. Tennent, Guglielmo Verona, Riccardo Porcari, P. Patrizia Mangione, Julian D. Gillmore, Mark B. Pepys, Vittorio Bellotti, Philip N. Hawkins, Raya Al-Shawi, J. Paul Simons
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Externí odkaz:
https://doaj.org/article/52dd9743e5e94eff8fed79314e07bdac
Autor:
Guglielmo Verona, P. Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D. Gillmore, Philip N. Hawkins, Mark B. Pepys, Graham W. Taylor, Vittorio Bellotti
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule
Externí odkaz:
https://doaj.org/article/f338b2bcadbe45189416b0237ad95585
Autor:
Mark. B. Pepys
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The phylogenetically ancient, pentraxin family of plasma proteins, comprises C-reactive protein (CRP) and serum amyloid P component (SAP) in humans and the homologous proteins in other species. They are composed of five, identical, non-covalently ass
Externí odkaz:
https://doaj.org/article/0a521798f0a04b58aa20623297467cd1
Autor:
Ronny Milde, Julia Ritter, Glenys A. Tennent, Andrzej Loesch, Fernando O. Martinez, Siamon Gordon, Mark B. Pepys, Admar Verschoor, Laura Helming
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1937-1948 (2015)
Multinucleated giant cells (MGCs) form by fusion of macrophages and are presumed to contribute to the removal of debris from tissues. In a systematic in vitro analysis, we show that IL-4-induced MGCs phagocytosed large and complement-opsonized materi
Externí odkaz:
https://doaj.org/article/83113f800f1b4f9b954b593c1e057032
Autor:
Nicola J Borthwick, Thirusha Lane, Nathifa Moyo, Alison Crook, Jung Min Shim, Ian Baines, Edmund G Wee, Philip N Hawkins, Julian D Gillmore, Tomáš Hanke, Mark B Pepys
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197299 (2018)
BACKGROUND:The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amylo
Externí odkaz:
https://doaj.org/article/7a2fa7f9bc0c42c7b0828285a71cde8e
Autor:
Raya Al-Shawi, Glenys A. Tennent, David J. Millar, Angela Richard-Londt, Sebastian Brandner, David J. Werring, J. Paul Simons, Mark B. Pepys
Publikováno v:
Open Biology, Vol 6, Iss 2 (2016)
Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovas
Externí odkaz:
https://doaj.org/article/f396179e10544602bce8dcc7789466b1
Autor:
P. Patrizia Mangione, Stéphanie Deroo, Stephan Ellmerich, Vittorio Bellotti, Simon Kolstoe, Stephen P. Wood, Carol V. Robinson, Martin D. Smith, Glenys A. Tennent, Robert J. Broadbridge, Claire E. Council, Joanne R. Thurston, Victoria A. Steadman, Antonio K. Vong, Christopher J. Swain, Mark B. Pepys, Graham W. Taylor
Publikováno v:
Open Biology, Vol 5, Iss 9 (2015)
Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease.
Externí odkaz:
https://doaj.org/article/92a745814544494abf587c612d2605eb
Autor:
Stephen B. Wharton, Carol Brayne, Stuart Pickering-Brown, Thais Minett, Amand F. Schmidt, Mark B. Pepys, Paul G. Ince, Graham W. Taylor, Tom Dening, Louise Robinson, C Richardson, Linda Clare, Simon Harrison, Sarah T. Pendlebury, Carol Jagger, Raphael Wittenberg, G. Forster, Ageing Study, Ian G. McKeith, Fiona E. Matthews, Bob Woods, Adelina Comas-Herrera, Roy O. Weller, Blossom C. M. Stephan, Linda E Barnes, Bronwyn Parry, Stephan Ellmerich, Antony Arthur
Publikováno v:
Brain Communications
Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer’s disease and some other common dementias is not known. The normal human plasma protein, serum amyloid P component, a constituent