Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Mark B, Hampton"'
Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
This research investigates the intricate dynamics of DNA methylation in the hours following CD8+ T cell activation, during a critical yet understudied temporal window. DNA methylation is an epigenetic modification central to regulation of gene expres
Externí odkaz:
https://doaj.org/article/4c7b5ec4ac0d49a8b2ab5486a7906dfa
Autor:
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high lev
Externí odkaz:
https://doaj.org/article/4881c6c2cd424db9be6a4d32261c425f
Autor:
Issam M Mayyas, Robert J Weeks, Robert C Day, Helena E Magrath, Karina M O’Connor, Olga Kardailsky, Timothy A Hore, Mark B Hampton, Ian M Morison
Publikováno v:
Epigenetics, Vol 16, Iss 11, Pp 1251-1259 (2021)
Although the mechanism of DNA demethylating drugs has been understood for many years, the direct effect of these drugs on methylation of the complementary strands of DNA has not been formally demonstrated. By using hairpin-bisulphite sequencing, we d
Externí odkaz:
https://doaj.org/article/1c6526df08f64f94b446cbb0b8761e4c
Autor:
Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton, Aaron J. Stevens
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Background Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen p
Externí odkaz:
https://doaj.org/article/76705e9ea37444d39a7a32b5c3689805
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The mycobacterium genus contains a broad range of species, including the human pathogens M. tuberculosis and M. leprae. These bacteria are best known for their residence inside host cells. Neutrophils are frequently observed at sites of mycobacterial
Externí odkaz:
https://doaj.org/article/827aff6828d64c0ea1db5a16b3674ecc
Autor:
Carlos C. Smith-Díaz, Nicholas J. Magon, Judith L. McKenzie, Mark B. Hampton, Margreet C. M. Vissers, Andrew B. Das
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Loss-of-function mutations in the DNA demethylase TET2 are associated with the dysregulation of hematopoietic stem cell differentiation and arise in approximately 10% of de novo acute myeloid leukemia (AML). TET2 mutations coexist with other mutation
Externí odkaz:
https://doaj.org/article/5666ba93b57445d6afc661eecad37b0a
Autor:
Andree G. Pearson, Juliet M. Pullar, John Cook, Emma S. Spencer, Margreet CM. Vissers, Anitra C. Carr, Mark B. Hampton
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101980- (2021)
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition meta
Externí odkaz:
https://doaj.org/article/7b9ed30450164947a618657be3e76d45
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101946- (2021)
Background: Macrophage migration inhibitory factor (MIF) is an important immuno-regulatory cytokine and is elevated in inflammatory conditions. Neutrophils are the first immune cells to migrate to sites of infection and inflammation, where they gener
Externí odkaz:
https://doaj.org/article/5a838ff21ae8406383056ff5694f6abf
Autor:
Mark B. Hampton, Nina Dickerhof
Publikováno v:
Immunological Reviews. 314:197-209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5419a01fd31947bbfb4896ae1eea969c
https://doi.org/10.1111/imr.13182
https://doi.org/10.1111/imr.13182
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 608 (2022)
Inflammation is a common feature of neurological diseases. During neuroinflammation, neutrophils are recruited to the brain vasculature, where myeloperoxidase can produce hypochlorous acid and the less well-studied oxidant hypothiocyanous acid (HOSCN
Externí odkaz:
https://doaj.org/article/ab3c6067648a4ffa81ac2d848d42cc7b