Výsledky vyhledávání - "Mark B, Cannell"

Akademický článek

Modulation of Spontaneous Action Potential Rate by Inositol Trisphosphate in Myocytes from the Rabbit Atrioventricular Node

Autor: Hongwei Cheng, Cherrie H. T. Kong, Andrew F. James, Mark B. Cannell, Jules C. Hancox

Publikováno v: Cells, Vol 13, Iss 17, p 1455 (2024)

The atrioventricular node (AVN) is a key component of the cardiac conduction system and takes over pacemaking of the ventricles if the sinoatrial node fails. IP3 (inositol 1,4,5 trisphosphate) can modulate excitability of myocytes from other regions

Externí odkaz: https://doaj.org/article/4a47348269214342815b39f379da96ab

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Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes

Autor: Ewan D. Fowler, Nan Wang, Melanie J. Hezzell, Guillaume Chanoit, Jules C. Hancox, Mark B. Cannell

Publikováno v: Fowler, E D, Wang, N, Hezzell, M J, Chanoit, G P A, Hancox, J C & Cannell, M B 2022, ' Improved Ca2+ release synchrony following selective modification of Itof and phase 1 repolarization in normal and failing ventricular myocytes ', Journal of Molecular and Cellular Cardiology, vol. 172, pp. 52-62 . https://doi.org/10.1016/j.yjmcc.2022.07.009

Loss of ventricular action potential (AP) early phase 1 repolarization may contribute to the impaired Ca 2+ release and increased risk of sudden cardiac death in heart failure. Therefore, restoring AP phase 1 by augmenting the fast transient outward

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af63b3fe9cbe654454231b868869be3
https://doi.org/10.1016/j.yjmcc.2022.07.009

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Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography

Autor: Eva A. Rog-Zielinska, Robin Moss, Gunnar Seemann, W. Kaltenbacher, Peter Kohl, Joachim Greiner, Mark B. Cannell, Paul Verkade

Publikováno v: et al. 2020, ' Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography ', Journal of Molecular and Cellular Cardiology, vol. 153, pp. 86-92 . https://doi.org/10.1016/j.yjmcc.2020.12.006
Journal of Molecular and Cellular Cardiology

Detailed knowledge of the ultrastructure of intracellular compartments is a prerequisite for our understanding of how cells function. In cardiac muscle cells, close apposition of transverse (t)-tubule (TT) and sarcoplasmic reticulum (SR) membranes su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca46d481ad8cc5095eae841a4d9179ee
https://doi.org/10.1016/j.yjmcc.2020.12.006

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Improved Ca

Autor: Ewan D, Fowler, Nan, Wang, Melanie J, Hezzell, Guillaume, Chanoit, Jules C, Hancox, Mark B, Cannell

Publikováno v: Journal of molecular and cellular cardiology. 172

Loss of ventricular action potential (AP) early phase 1 repolarization may contribute to the impaired Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7d423b8375be7a3cf824b0b7f55a9b9
https://pubmed.ncbi.nlm.nih.gov/35908686

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Akademický článek

Heterogeneity of T-Tubules in Pig Hearts.

Autor: Hanne C Gadeberg, Richard C Bond, Cherrie H T Kong, Guillaume P Chanoit, Raimondo Ascione, Mark B Cannell, Andrew F James

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156862 (2016)

BACKGROUND:T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were generally considered to be effectively absent in atrial myocytes, recent studies o

Externí odkaz: https://doaj.org/article/05e15242b8ac42268cd5f465f4792dbd

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Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene

Autor: Jules C. Hancox, Nan Wang, Stephen C Harmer, Ewan D. Fowler, Mark B. Cannell, Eef Dries

Publikováno v: Wang, N, Dries, E, Fowler, E D, Harmer, S C, Hancox, J C & Cannell, M B 2021, ' Inducing Ito,f and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene ', Journal of Molecular and Cellular Cardiology, vol. 164, pp. 29-41 . https://doi.org/10.1016/j.yjmcc.2021.11.004

The fast transient outward potassium current (Ito,f) plays a key role in phase 1 repolarization of the human cardiac action potential (AP) and its reduction in heart failure (HF) contributes to the loss of contractility. Therefore, restoring Ito,f mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5ca7ed2fb95d73d98b22469c4bae5e
https://research-information.bris.ac.uk/ws/files/304888323/1_s2.0_S0022282821002194_main_2.pdf

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Akademický článek

The Involvement of TRPC3 channels in Sinoatrial Arrhythmias

Autor: Yue-Kun eJu, Bon Hyang Lee, Sofie eTrajanovska, Guoliang eHao, David G Allen, Ming eLei, Mark B Cannell

Publikováno v: Frontiers in Physiology, Vol 6 (2015)

Atrial fibrillation (AF) is a significant contributor to cardiovascular morbidity and mortality. The currently available treatments are limited and AF continues to be a major clinical challenge. Clinical studies have shown that AF is frequently assoc

Externí odkaz: https://doaj.org/article/aee9e542c28e47b8ad21788aad7bc129

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Akademický článek

Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload.

Autor: Haifei Zhang, Mark B Cannell, Shang Jin Kim, Judy J Watson, Ruth Norman, Sarah C Calaghan, Clive H Orchard, Andrew F James

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144309 (2015)

Atrial remodeling due to elevated arterial pressure predisposes the heart to atrial fibrillation (AF). Although abnormal sarcoplasmic reticulum (SR) function has been associated with AF, there is little information on the effects of elevated afterloa

Externí odkaz: https://doaj.org/article/25c6851491914da6a8505d06140b58e6

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Akademický článek

Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach.

Autor: Cherrie H T Kong, Derek R Laver, Mark B Cannell

Publikováno v: PLoS Computational Biology, Vol 9, Iss 2, p e1002931 (2013)

The release of Ca from intracellular stores is key to cardiac muscle function; however, the molecular control of intracellular Ca release remains unclear. Depletion of the intracellular Ca store (sarcoplasmic reticulum, SR) may play an important role

Externí odkaz: https://doaj.org/article/e4dee497024445bb90bc8c597112d83b

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Akademický článek

4D super-resolution microscopy with conventional fluorophores and single wavelength excitation in optically thick cells and tissues.

Autor: David Baddeley, David Crossman, Sabrina Rossberger, Juliette E Cheyne, Johanna M Montgomery, Isuru D Jayasinghe, Christoph Cremer, Mark B Cannell, Christian Soeller

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e20645 (2011)

BackgroundOptical super-resolution imaging of fluorescently stained biological samples is rapidly becoming an important tool to investigate protein distribution at the molecular scale. It is therefore important to develop practical super-resolution m

Externí odkaz: https://doaj.org/article/275e5a23c994488d9b10d4bad1c78623

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