Sialorrhea in Amyotrophic Lateral Sclerosis

Autor: Mark B. Bromberg

Publikováno v: Respiratory Symptoms ISBN: 0190098899

Sialorrhea can be defined as pooling of saliva due to inefficient swallowing. In amyotrophic lateral sclerosis (ALS), weakness and poor coordination of cheek and tongue muscles and muscles involved with swallowing prevent clearing the 1-plus quarts o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cbf163570b8551fa4c96a54b8311c1b
https://doi.org/10.1093/med/9780190098896.003.0017

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial

Autor: Michael Pulley, Mikko Kuoppamäki, Carolyn A Young, Jesus S. Mora Pardina, Kumaraswamy Sivakumar, Toni Sarapohja, Michael A. Elliott, Chafic Karam, Sandeep Rana, Orla Hardiman, Nathan P. Staff, Letizia Mazzini, Gabriele Mora, Thomas F. Meyer, Colleen O'Connell, Stéphanie Delstanche, Elham Bayat, Michael D. Weiss, Waqar Waheed, Nenad Mitrovic, Philippe Corcia, Marie-Hélène Soriani, Edward J. Kasarskis, Claudia Caponnetto, Dale J. Lange, Tuan Vu, Leo McCluskey, Berthold Schrank, Angela Genge, Matthew C. Kiernan, Valtteri V Aho, Manu Jokela, Philip Van Damme, Juan F. Vázquez Costa, Maurizio Inghilleri, Wolfgang Löscher, David Schultz, Tero Tapiola, Susanne Petri, Adriano Chiò, Gary L. Pattee, Julian Großkreutz, Ammar Al-Chalabi, Aziz Shaibani, Susan Mathers, Kevin J. Felice, Kimberly Goslin, James Caress, Matthias Boentert, Albert C. Ludolph, Aleksandar Radunovic, Robert D. Henderson, James Wymer, Todd Levine, Jakob Rath, Merrilee Needham, William Camu, Gaurav Guliani, Rune Johansson, Leonard H. van den Berg, Namita Goyal, Mark B. Bromberg, Bjorn Oskarsson, Annie Dionne, Eduardo Locatelli, Brent T. Harris, Suma Babu, Richard Bedlack, John Ravits, Jinsy A. Andrews, Philippe Couratier, Gabriele Siciliano, Hannu Laaksovirta, Kourosh Rezania, Lawrence Korngut, Eduardo Aguera Morales, Peter M Andersen, Eva Farrero Munoz, David Lacomis, Stephen N. Scelsa, Chris Garratt, Matthew Burford, Merit Cudkowicz, Nicholas J. Maragakis, Wendy Johnston, Martin M. Brown, Johannes Prudlo, Justin Y. Kwan, Dominic B. Fee, Senda Ajroud-Driss, Stephen A. Goutman, John Turnbull, Michael H. Rivner, Timothy M. Miller, Jan De Bleecker, Caroline Ingre, Luis Varona, Genevieve Matte, Daragh Heitzman, Robert Untucht, Lorne Zinman, Adam Quick, Jonathan S. Katz

Publikováno v: The Lancet Neurology. 20:821-831

Summary Background There is an urgent unmet need for new therapies in amyotrophic lateral sclerosis. In a clinical study with healthy volunteers, levosimendan, a calcium sensitiser, was shown to improve neuromechanical efficiency and contractile func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e159b8bed1a737713c1c2f5bf0a571
https://doi.org/10.1016/s1474-4422(21)00242-8

What is in the Literature

Autor: Mark B, Bromberg

Publikováno v: Journal of Clinical Neuromuscular Disease. 22:200-208

This edition of What is in the Literature focuses on chronic immune neuropathies as they represent treatable conditions. There are formal criteria to solidify the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5df510173f4b8be6f186677207a750
https://doi.org/10.1097/cnd.0000000000000371

The motor unit and quantitative electromyography

Autor: Mark B. Bromberg

Publikováno v: Muscle & Nerve. 61:131-142

Electromyography (EMG) assesses the anatomic motor unit (A-MU), but knowledge of its anatomy, physiology, and changes with pathology is limited. The electrophysiological motor unit (E-MU) and its motor unit potential (E-MUP) represents a fraction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba97bdebaab3eaf8c44454f801ddf74
https://doi.org/10.1002/mus.26718

Bowel, bladder, and sudomotor symptoms in ALS patients

Autor: Summer Gibson, Mark B. Bromberg, Patricia Jerant, Verena Clarissa Samara

Publikováno v: Journal of the neurological sciences. 427

Objectives To describe prevalence rates of bowel, bladder, and sudomotor symptoms in patients with amyotrophic lateral sclerosis (ALS) in relation to disease onset and progression. Treatment strategies and efficacies were also assessed. Methods A pil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b707b4f321ebf19c9f1190751e56130
https://pubmed.ncbi.nlm.nih.gov/34182195