Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Mark Ansel"'
Autor:
Wandi S. Zhu, Adam J. Litterman, Harshaan S. Sekhon, Robin Kageyama, Maya M. Arce, Kimberly E. Taylor, Wenxue Zhao, Lindsey A. Criswell, Noah Zaitlen, David J. Erle, K. Mark Ansel
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)
Abstract GCLiPP is a global RNA interactome capture method that detects RNA-binding protein (RBP) occupancy transcriptome-wide. GCLiPP maps RBP-occupied sites at a higher resolution than phase separation-based techniques. GCLiPP sequence tags corresp
Externí odkaz:
https://doaj.org/article/d9d0f867d61c4eb2b44c5c8f804f28be
Autor:
Benjamin D Wheeler, John D Gagnon, Wandi S Zhu, Priscila Muñoz-Sandoval, Simon K Wong, Dimitre S Simeonov, Zhongmei Li, Rachel DeBarge, Matthew H Spitzer, Alexander Marson, K Mark Ansel
Publikováno v:
eLife, Vol 12 (2023)
Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we u
Externí odkaz:
https://doaj.org/article/6b38f61a3ba74929aacd66d5b01fa903
Autor:
Juliana Durack, Yvonne J. Huang, Snehal Nariya, Laura S. Christian, K. Mark Ansel, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, Elliot Israel, Monica Kraft, Richard J. Martin, David T. Mauger, Sharon R. Rosenberg, Tonya S. King, Steven R. White, Loren C. Denlinger, Fernando Holguin, Stephen C. Lazarus, Njira Lugogo, Stephen P. Peters, Lewis J. Smith, Michael E. Wechsler, Susan V. Lynch, Homer A. Boushey, for the National Heart, Lung and Blood Institute’s “AsthmaNet”
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Background Perturbations to the composition and function of bronchial bacterial communities appear to contribute to the pathophysiology of asthma. Unraveling the nature and mechanisms of these complex associations will require large longitud
Externí odkaz:
https://doaj.org/article/5538c642bfd445ad965fdb041e6f0901
Autor:
Rakesh Chatrikhi, Michael J. Mallory, Matthew R. Gazzara, Laura M. Agosto, Wandi S. Zhu, Adam J. Litterman, K. Mark Ansel, Kristen W. Lynch
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2795-2806.e3 (2019)
Summary: The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3′ UTRs of human messages are not invariant for each gene but rather are shaped by alternative polyadenylation (APA) in a
Externí odkaz:
https://doaj.org/article/24e2d5b4eee94f89b827dc74c1f9e0e4
Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3356-3370.e4 (2018)
Summary: The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a novel mode of intercellular communication and uncovered a link between cellular endomembrane compartments and small RNAs in EV-secreting cells. Using a tw
Externí odkaz:
https://doaj.org/article/ee28c613a42f4acb993e72c5f81bdd2c
Autor:
Matvei Khoroshkin, Daniel Asarnow, Albertas Navickas, Aidan Winters, Johnny Yu, Simon K. Zhou, Shaopu Zhou, Christina Palka, Lisa Fish, K. Mark Ansel, Yifan Cheng, Luke A. Gilbert, Hani Goodarzi
RNA structural switches are key regulators of gene expression in bacteria, yet their characterization in Metazoa remains limited. Here we present SwitchSeeker, a comprehensive computational and experimental approach for systematic identification of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca88a7cf81a398c395f036e0ef5d8d2c
https://doi.org/10.1101/2023.03.11.532161
https://doi.org/10.1101/2023.03.11.532161
Autor:
Kristina Johansson, John D. Gagnon, Simon Zhou, Marlys S. Fassett, Andrew W. Schroeder, Robin Kageyama, Rodriel A. Bautista, Hewlett Pham, Prescott G. Woodruff, K. Mark Ansel
Publikováno v:
bioRxiv
The miR-15/16 family is a highly expressed group of tumor suppressor miRNAs that target a large network of genes in T cells to restrict their cell cycle, memory formation and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced896e4ed6b67fe3088fbf68141ba69
https://doi.org/10.2139/ssrn.4441801
https://doi.org/10.2139/ssrn.4441801
Autor:
Marianne Dölz, Marko Hasiuk, John D. Gagnon, Mara Kornete, Romina Marone, Glenn Bantug, Robin Kageyama, Christoph Hess, K. Mark Ansel, Denis Seyres, Julien Roux, Lukas T. Jeker
Funder: Horizon 2020 Framework Programme
Funder: National Institutes of Health
CD28 provides the prototypical costimulatory signal required for productive T-cell activation. Known molecular consequences of CD28 costimulation are mostly base
Funder: National Institutes of Health
CD28 provides the prototypical costimulatory signal required for productive T-cell activation. Known molecular consequences of CD28 costimulation are mostly base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e1446d5eeb017e1c9f3f11d0898c41
Autor:
K. Mark Ansel, Eric J. Wigton
Publikováno v:
RNA Biol
RNA biology, vol 18, iss 5
RNA biology, vol 18, iss 5
B cells constitute a main branch adaptive immune system. They mediate host defence through the production of high-affinity antibodies against an enormous diversity of foreign antigens. Remarkably, B cells undergo multiple types of somatic DNA mutatio