Výsledky vyhledávání - "Mark Anczurowski"

Akademický článek

Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

Publikováno v: eLife, Vol 9 (2020)

HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles prevalent in a subset of ethnic groups. Here, using a panel of newly developed peptide-exchange

Externí odkaz: https://doaj.org/article/d455cc6e68c4440b81ba240acbcb367a

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Akademický článek

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

Autor: Yuki Kagoya, Munehide Nakatsugawa, Kayoko Saso, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Marcus O. Butler, Cheryl H. Arrowsmith, Naoto Hirano

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Adoptive T cell therapy using an allogeneic T cell graft is an encouraging therapeutic approach in cancer, but issues such as graft-versus-host disease can hinder applicability. Here, the authors show that DOT1L inhibition or DUSP6 overexpression in

Externí odkaz: https://doaj.org/article/d6ce55cb15b249f6b173e89e668c2976

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Akademický článek

HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway

Autor: Yuki Yamashita, Mark Anczurowski, Munehide Nakatsugawa, Makito Tanaka, Yuki Kagoya, Ankit Sinha, Kenji Chamoto, Toshiki Ochi, Tingxi Guo, Kayoko Saso, Marcus O. Butler, Mark D. Minden, Thomas Kislinger, Naoto Hirano

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP84Glyuses both class I and II mechanisms to constitutively present pe

Externí odkaz: https://doaj.org/article/6fca40eaed414738a7794321edcd0a22

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Akademický článek

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors.

Autor: Tingxi Guo, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi, Yuki Yamashita, Mark Anczurowski, Marcus O Butler, Naoto Hirano

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0156114 (2016)

Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice. Th

Externí odkaz: https://doaj.org/article/3cda122c78174bf59909393caef671e5

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Data from Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy

Autor: Naoto Hirano, Marcus O. Butler, Yota Ohashi, Yukiko Matsunaga, Hiroshi Saijo, Kenji Sugata, Kenji Murata, Chung-Hsi Wang, Mark Anczurowski, Kayoko Saso, Brian Yeung, Tingxi Guo, Yuki Kagoya

Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T-cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb5fb34a5edad3330af3b54055a68c
https://doi.org/10.1158/2326-6066.c.6550458

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Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy

Autor: Yukiko Matsunaga, Mark Anczurowski, Kenji Sugata, Naoto Hirano, Chung-Hsi Wang, Marcus O. Butler, Kayoko Saso, Kenji Murata, Yuki Kagoya, Brian Yeung, Yota Ohashi, Tingxi Guo, Hiroshi Saijo

Publikováno v: Cancer Immunology Research. 8:926-936

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2f6952b50148f1219ef5933695ec64
https://doi.org/10.1158/2326-6066.cir-18-0508

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Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells

Autor: Cheryl H. Arrowsmith, Chung-Hsi Wang, Mark Anczurowski, Yuki Kagoya, Kenji Murata, Marcus O. Butler, Naoto Hirano, Yukiko Matsunaga, Tingxi Guo, Hiroshi Saijo, Kayoko Saso, Kenji Sugata

Publikováno v: Journal of Autoimmunity. 97:10-21

Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7392e75a43be8b64bf29d0f5d47141
https://doi.org/10.1016/j.jaut.2018.09.011

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