Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark Alexander Skarsfeldt"'
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100898- (2021)
Background: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion c
Externí odkaz:
https://doaj.org/article/82411e8ecce4417c847b406d7fefec9e
Autor:
Jonas Goldin Diness, Lea Abildgaard, Sofia Hammami Bomholtz, Mark Alexander Skarsfeldt, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundHypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductan
Externí odkaz:
https://doaj.org/article/20be621c8ddb4634a78c173606c22392
Autor:
Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IK
Externí odkaz:
https://doaj.org/article/0dc2f2226e674b7996e9529f482bfbcc
Publikováno v:
Yan, Y, Skarsfeldt, M A, Diness, J G & Bentzen, B H 2021, ' Small conductance calcium activated K+ channel inhibitor decreases stretch induced vulnerability to atrial fibrillation ', IJC Heart and Vasculature, vol. 37, 100898 . https://doi.org/10.1016/j.ijcha.2021.100898
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss, Pp 100898-(2021)
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss, Pp 100898-(2021)
Background: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eee8b60d6d7bdfc553cbcd90e6869b
https://curis.ku.dk/ws/files/286414807/Small_conductance_calcium_activated_K_channel_inhibitor_decreases_stretch.pdf
https://curis.ku.dk/ws/files/286414807/Small_conductance_calcium_activated_K_channel_inhibitor_decreases_stretch.pdf
Autor:
Jonas Goldin, Diness, Lea, Abildgaard, Sofia Hammami, Bomholtz, Mark Alexander, Skarsfeldt, Nils, Edvardsson, Ulrik S, Sørensen, Morten, Grunnet, Bo Hjorth, Bentzen
Publikováno v:
Frontiers in Pharmacology
Background Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents. Small conduct
Autor:
Jeppe Egedal, Kirchhoff, Mark Alexander, Skarsfeldt, Kalai Mangai, Muthukumarasamy, Rafel, Simó-Vicens, Sofia Hammami, Bomholtz, Lea, Abildgaard, Thomas, Jespersen, Ulrik S, Sørensen, Morten, Grunnet, Bo Hjorth, Bentzen, Jonas Goldin, Diness
Publikováno v:
Frontiers in Pharmacology
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IK
Autor:
Emilie Gregers, Sofia Hammami Bomholtz, Thomas A. Jepps, Jesper Hastrup Svendsen, Nicole Schmitt, Søren-Peter Olesen, Mark Alexander Skarsfeldt, Lea Abildgaard, Ulrik Svane Sørensen, Bo Hjorth Bentzen, Jonas Goldin Diness, Morten Grunnet
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:643-654
In isolated human atrial cardiomyocytes, inhibition of K2P3.1 K(+) channels results in action potential (action potential duration (APD)) prolongation. It has therefore been postulated that K2P3.1 (KCNK3), together with K2P9.1 (KCNK9), could represen
Autor:
Bo Hjorth Bentzen, Rene Barro-Soria, Teija Parkkari, Fredrik Elinder, Mark Alexander Skarsfeldt, Sara I. Liin, Johan E. Larsson, H. Peter Larsson, Malin Silverå Ejneby, Nicole Schmitt, Frida Starck Härlin
Publikováno v:
Proceedings of the National Academy of Sciences. 112:5714-5719
Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the beta-subunit KCNE1 form the cardiac I-Ks channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as I-Ks channel modulators. W
Autor:
Sofia Hammami Bomholtz, Mark Alexander Skarsfeldt, Martin Tristani-Firouzi, Pia R. Lundegaard, Angelica Lopez-Izquierdo, Bo Hjorth Bentzen
Publikováno v:
Acta Physiologica. 223:e13049
Aim The zebrafish has emerged as a novel model for investigating cardiac physiology and pathology. The aim of this study was to investigate the atrium-specific ion channels responsible for shaping the atrial cardiac action potential in zebrafish. Met
Autor:
Johan E. Larsson, Rene Barro-Soria, Mark Alexander Skarsfeldt, H. Peter Larsson, Sara I. Liin, Bo Hjorth Bentzen
Publikováno v:
Biophysical Journal. 110(3):185a-186a
The cardiac I←Ks channel is important for cardiomyocyte repolarization. More than 300 loss-of-function mutations in the genes encoding I←Ks have been identified in patients with Long QT syndrome. These mutations cause cardiac arrhythmias, such as