Výsledky vyhledávání - "Mark A.J Gorris"

Akademický článek

The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients

Autor: Cristina Graham Martínez, Yari Barella, Sonay Kus Öztürk, Marleen Ansems, Mark A.J Gorris, Shannon van Vliet, Corrie A.M Marijnen, Iris D Nagtegaal

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Neoadjuvant therapy is the cornerstone of modern rectal cancer treatment. Insights into the biology of tumor responses are essential for the successful implementation of organ-preserving strategies, as different treatments may lead to specific tumor

Externí odkaz: https://doaj.org/article/3c8f748390094bf2bdf7c9dc18db47c5

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Akademický článek

Exploring immune status in peripheral blood and tumor tissue in association with survival in patients with multi-organ metastatic colorectal cancer

Autor: Lotte Bakkerus, Beatriz Subtil, Hetty J. Bontkes, Elske C. Gootjes, Martine Reijm, Manon Vullings, Kiek Verrijp, John-Melle Bokhorst, Carmen Woortman, Iris D. Nagtegaal, Marianne A. Jonker, Hans J. van der Vliet, Cornelis Verhoef, Mark A.J. Gorris, I. Jolanda M. de Vries, Tanja D. de Gruijl, Henk M.W. Verheul, Tineke E. Buffart, Daniele V. F. Tauriello

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Colorectal cancer (CRC) raises considerable clinical challenges, including a high mortality rate once the tumor spreads to distant sites. At this advanced stage, more accurate prediction of prognosis and treatment outcome is urgently needed. The role

Externí odkaz: https://doaj.org/article/d840e76947914521ba035fcfccc6eb05

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Akademický článek

Immunological responses to adjuvant vaccination with combined CD1c+ myeloid and plasmacytoid dendritic cells in stage III melanoma patients

Autor: Martine Bloemendal, Kalijn F. Bol, Steve Boudewijns, Mark A.J. Gorris, Johannes H.W. de Wilt, Sandra A.J. Croockewit, Michelle M. van Rossum, Anna L. de Goede, Katja Petry, Rutger H.T. Koornstra, Carl Figdor, Winald R. Gerritsen, Gerty Schreibelt, I. Jolanda M. de Vries

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

We evaluated the immunological responses of lymph-node involved (stage III) melanoma patients to adjuvant dendritic cell vaccination with subsets of naturally occurring dendritic cells (nDCs). Fifteen patients with completely resected stage III melan

Externí odkaz: https://doaj.org/article/dfeb5f9d6c48480e92a7469ad71b0589

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Akademický článek

Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination

Autor: Jasper J.P. van Beek, Georgina Flórez-Grau, Mark A.J. Gorris, Till S.M. Mathan, Gerty Schreibelt, Kalijn F. Bol, Johannes Textor, I. Jolanda M. de Vries

Publikováno v: Cell Reports, Vol 30, Iss 4, Pp 1027-1038.e4 (2020)

Summary: Plasmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (cDC2s) are currently under evaluation for use in cancer vaccines. Although both DC subsets can activate adaptive and innate lymphocytes, their capacity to recruit s

Externí odkaz: https://doaj.org/article/bb84160f4b9a4aa5b237c04e5208558c

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Supplementary Figures S1-S12 from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

Autor: I. Jolanda M. de Vries, Carl G. Figdor, Evelien L. Smits, Christoph Schröder, Tjitske Duiveman-de Boer, Ruurd Torensma, Simone P. Sittig, Gerty Schreibelt, Annette E. Sköld, Stanleyson V. Hato, Altuna Halilovic, Mark A.J. Gorris, Sonja I. Buschow, Ghaith Bakdash

The gating strategy applied to isolate and determine the frequency of BDCA1+ DCs, BDCA1+ CD14+ cells, monocytes and MDSCs from PBMCS of melanoma patients or healthy donors by FACS (S1); The distribution of potentially "missed genes" over the RPKM val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76be5ea82aa72def3b1201e320c64fce
https://doi.org/10.1158/0008-5472.22409060

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Supplementary Dataset S1 from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

The detailed composition of all gene sets used in GSEA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8626e51d068ac8080aa662b60916b22
https://doi.org/10.1158/0008-5472.22409063

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Data from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

The tumor microenvironment is characterized by regulatory T cells, type II macrophages, myeloid-derived suppressor cells, and other immunosuppressive cells that promote malignant progression. Here we report the identification of a novel BDCA1+CD14+ p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e679dae9c4aaa351965e21d4a774c9
https://doi.org/10.1158/0008-5472.c.6507674.v1

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Supplementary Table S2 from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

GSEA raw data generated by Bubble GUM software.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc137de3b2967ed858ff22ff7fe80cd
https://doi.org/10.1158/0008-5472.22409054.v1

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Supplementary Table and Figure Legends from Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S12.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928fac62dbf491c7b0c266f2bb31691e
https://doi.org/10.1158/0008-5472.22409051.v1

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Topography of immune cell infiltration in different stages of coronary atherosclerosis revealed by multiplex immunohistochemistry

Autor: Kimberley R.G. Cortenbach, Daniel Morales Cano, Jelena Meek, Mark A.J. Gorris, Alexander H.J. Staal, Mangala Srinivas, I. Jolanda M. de Vries, Jacob Fog Bentzon, Roland R.J. van Kimmenade

Publikováno v: International journal of cardiology. Heart & vasculature, 44
IJC Heart and Vasculature, 44
IJC Heart and Vasculature 44 (2023)

Contains fulltext : 291341.pdf (Publisher’s version ) (Open Access) BACKGROUND: Aim of this study was to investigate immune cells and subsets in different stages of human coronary artery disease with a novel multiplex immunohistochemistry (mIHC) te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cb8ae7bf7ef33b579d48294f5bcbf6

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