Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Mark A. Zabezhinski"'
Autor:
Tatiana S. Piskunova, Maria N. Yurova, Anton I. Ovsyannikov, Anna V. Semenchenko, Mark A. Zabezhinski, Irina G. Popovich, Zhao-Qi Wang, Vladimir N. Anisimov
Publikováno v:
Current Gerontology and Geriatrics Research, Vol 2008 (2008)
Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis
Externí odkaz:
https://doaj.org/article/1d5d8f85d5034b1f900cfa006ccb70aa
Autor:
Ivan V. Anikin, Maria N. Yurova, Vladimir N. Anisimov, Sergey E. Pigarev, Andrey V. Panchenko, Margarita L. Tyndyk, Elena I. Fedoros, Irina G. Popovich, Peter A. Egormin, Irina Baldueva, Mark A. Zabezhinski
Publikováno v:
Aging (Albany NY)
Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some biomarkers of aging, life span and spontaneous tumorigenesis has been studied in female SHR m
Autor:
Nikolai V. Khaitsev, Maria N. Yurova, Anna V. Semenchenko, Andrey G. Vasiliev, Peter A. Egormin, Andrey V. Panchenko, Margarita L. Tyndyk, Mark A. Zabezhinski, Irina G. Popovich, A. P. Trashkov, Vladimir N. Anisimov
Publikováno v:
Cell Cycle. 14:46-55
The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabeti
Autor:
Maria N. Yurova, Vladimir N. Anisimov, Irina G. Popovich, Andrei V. Panchenko, Mark A. Zabezhinski, Maragriata L. Tyndyk, Tatiana S. Piskunova, Anna V. Semenchenko
Publikováno v:
Cell Cycle. 12:1785-1790
The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting from the age of 2 mo were kept under standard light/dark regimen [12 h light (70 lx):12 hr
Autor:
Maria N. Yurova, Mark A. Zabezhinski, Margarita L. Tyndyk, Andrey V. Panchenko, Stukov An, Valeri A. Alexandrov, Irina G. Popovich, Gennady B Pliss, Anna V. Semenchenko, Irina Alimova, Tatiana S. Piskunova, Vladimir G. Bespalov, Peter А Egormin, Vladimir N. Anisimov, Ivan V. Anikin
Publikováno v:
Expert Opinion on Drug Discovery. 7:85-95
There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span, maintaining normal physiological function, and alleviating the onset and severity of age-associat
Autor:
Irina G. Popovich, Tatiana E. Poroshina, Irina G. Kovalenko, Margarita L. Tyndyk, Vladimir N. Anisimov, Tatiana S. Piskunova, Peter A. Egormin, Anna V. Semenchenko, Lev M. Berstein, Maria N. Yurova, Mark A. Zabezhinski
Publikováno v:
Aging (Albany NY)
Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer in mice, although its effects vary, depending o
Autor:
Vladimir N. Anisimov, Tatiana S. Piskunova, Lev M. Berstein, Anna V. Semenchenko, Maria N. Yurova, Tatiana E. Poroshina, Margarita L. Tyndyk, Irina G. Popovich, Irina G. Kovalenko, Mark A. Zabezhinski, Svetlana V Rosenfeld, Peter A. Egormin
Publikováno v:
Aging (Albany NY)
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects of calorie restriction are due to decreasing I
Autor:
Viktor Ilyukha, Mark A. Zabezhinski, Vladimir N. Anisimov, Anna V. Semenchenko, Tatiana A. Lotosh, E. A. Khizhkin, A. V. Bukalev, I. A. Vinogradova
Publikováno v:
Aging (Albany NY)
We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the
Autor:
Anna V. Semenchenko, Mark A. Zabezhinski, Vladimir N. Anisimov, A. V. Bukalev, I. A. Vinogradova
Publikováno v:
Aging (Albany NY)
We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/d
Autor:
V. Kh. Khavinson, Bukalev Av, I. A. Vinogradova, Anna V. Semenchenko, Mark A. Zabezhinski, Vladimir N. Anisimov
Publikováno v:
Bulletin of Experimental Biology and Medicine. 145:472-477
Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light. Permanent illumination promoted the development of spontaneous tumors in compariso