Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mark A. Wallet"'
Autor:
Lucas H. Armitage, Scott E. Stimpson, Katherine E. Santostefano, Lina Sui, Similoluwa Ogundare, Brittney N. Newby, Roberto Castro-Gutierrez, Mollie K. Huber, Jared P. Taylor, Prerana Sharma, Ilian A. Radichev, Daniel J. Perry, Natalie C. Fredette, Alexei Y. Savinov, Mark A. Wallet, Naohiro Terada, Todd M. Brusko, Holger A. Russ, Jing Chen, Dieter Egli, Clayton E. Mathews
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothe
Externí odkaz:
https://doaj.org/article/4cc69f69404e4a1aa049c8589a0add98
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22, rs2476601, is associated with increased risk of Type 1 Diabetes (T1D) and other autoimm
Externí odkaz:
https://doaj.org/article/5b84b273f9d14320bced262cb6cd1b2b
Publikováno v:
Biology Open, Vol 9, Iss 12 (2020)
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency
Externí odkaz:
https://doaj.org/article/bf6490caf8cc425da1fef9474b339b54
Autor:
Chao Liu, Robert L. Whitener, Andrea Lin, Yuan Xu, Jing Chen, Alexei Savinov, Jennifer W. Leiding, Mark A. Wallet, Clayton E. Mathews
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Aims: Reactive oxygen species (ROS) are critical in driving the onset of type 1 diabetes (T1D). Ablation of ROS derived from phagocytic NADPH oxidase 2 is protective against autoimmune diabetes in non-obese diabetic (NOD) mice. However, the mechanism
Externí odkaz:
https://doaj.org/article/15dd33b14e2c44f2ae46b1d8b0060af4
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
At least 57 independent loci within the human genome confer varying degrees of risk for the development of type 1 diabetes (T1D). The majority of these variants are thought to contribute to overall genetic risk by modulating host innate and adaptive
Externí odkaz:
https://doaj.org/article/c85674893291422983304e7f5a0a78aa
Autor:
Katherine E. Santostefano, Fiona M. Docherty, Shane P.M. Williams, JaeAnn M. Dwulet, Maria S. Hansen, Richard K.P. Benninger, Kent Riemondy, Holger A. Russ, Ali H. Shilleh, Roberto Castro-Gutierrez, Taylor M. Triolo, Mark A. Wallet, Lucas H. Armitage, Clayton E. Mathews
Publikováno v:
Diabetes
Stem cell–derived β-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. T
Autor:
Viola R, Butfiloski Ej, Megan Sykes, Dieter Egli, Mark A. Wallet, Lucas H. Armitage, Clayton E. Mathews, Khosravi-Maharlooei M, Meacham A
Publikováno v:
SSRN Electronic Journal.
SummaryDifferentiation of induced pluripotent stem cells (iPSC) into monocytes, monocyte-derived macrophages (MDM), and monocyte-derived dendritic cells (moDC) represents a powerful tool for studying human innate immunology and developing novel iPSC-
Autor:
Roland W. Herzog, Laurence Morel, Cox Terhorst, Geoffrey D. Keeler, Irene Zolotukhin, Brad E. Hoffman, David M. Markusic, Jamie L. Shirley, Alexandra Sherman, Mark A. Wallet
Publikováno v:
Mol Ther
Adeno-associated virus (AAV) vectors are widely used in clinical gene therapy to correct genetic disease by in vivo gene transfer. Although the vectors are useful, in part because of their limited immunogenicity, immune responses directed at vector c
Autor:
Holger A. Russ, Richard K. P. Benninger, Taylor M. Triolo, Clayton E. Mathews, Mark A. Wallet, Katherine E. Santostefano, Lucas H. Armitage, Shane P. M. Williams, Maria S. Hansen, Ali H. Shilleh, JaeAnn M. Dwulet, Roberto Castro-Gutierrez, Kent A. Riemondy, Fiona M. Docherty
Stem cell derived beta-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc22ee33eb5e88c90298fcf3096fbdf
https://doi.org/10.2337/figshare.15124980.v3
https://doi.org/10.2337/figshare.15124980.v3
Publikováno v:
Frontiers in Immunology
Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) regulates a panoply of leukocyte signaling pathways. A single nucleotide polymorphism (SNP) in PTPN22, rs2476601, is associated with increased risk of Type 1 Diabetes (T1D) and other autoimm