Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark A. Villamil"'
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & cellular proteomics : MCP, vol 21, iss 1
Protein ubiquitylation is an important posttranslational modification that governs most cellular processes. Signaling functions of ubiquitylation are very diverse and involve proteolytic as well as nonproteolytic events, such as localization, regulat
Autor:
Qiuyan Lan, Jianping Jin, Zhongwei Xu, Wei Wei, Karin Flick, Mark A. Villamil, Yunping Zhu, Ping Xu, Lei Chang, Duc M. Duong, Junzhu Wu, Chengpu Zhang, Linda Lauinger, Lingyan Ping, Fuchu He, Eric B. Dammer, Xiaohua Xing, Peter K. Kaiser, Yuan Gao, Zixin Deng, Xuechuan Hong, Yanchang Li
Publikováno v:
Molecular cell, vol 76, iss 1
Mol Cell
Mol Cell
Summary A surprising complexity of ubiquitin signaling has emerged with identification of different ubiquitin chain topologies. However, mechanisms of how the diverse ubiquitin codes control biological processes remain poorly understood. Here, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eff8396495f7e0d39b77416ccf7df2
https://escholarship.org/uc/item/08n0q0xg
https://escholarship.org/uc/item/08n0q0xg
Autor:
Junjun Chen, Mark A. Villamil, Anton Simeonov, Qin Liang, Zhihao Zhuang, Hongmao Sun, David J. Maloney, Thomas S. Dexheimer, Edward H. Kerns, Diane K. Luci, Andrew S. Rosenthal, Ajit Jadhav
Publikováno v:
Journal of Medicinal Chemistry
Deregulation of ubiquitin conjugation or deconjugation has been implicated in the pathogenesis of many human diseases including cancer. The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1 (USP1-associated factor
Publikováno v:
Cell Biochemistry and Biophysics. 67:111-126
Ubiquitination has emerged as an essential signaling mechanism in eukaryotes. Deubiquitinases (DUBs) counteract the activities of the ubiquitination machinery and provide another level of control in cellular ubiquitination. Not surprisingly, DUBs are
Autor:
Szilvia Juhasz, Zhihao Zhuang, Ildiko Hajdu, David Balogh, Mark A. Villamil, Lajos Haracska, Peter Burkovics
Publikováno v:
Nucleic Acids Research
Unrepaired DNA damage may arrest ongoing replication forks, potentially resulting in fork collapse, increased mutagenesis and genomic instability. Replication through DNA lesions depends on mono- and polyubiquitylation of proliferating cell nuclear a
Autor:
Bi-Feng Yuan, David J. Maloney, Junjun Chen, Anton Simeonov, Ping Zhang, Changjun You, Mark A. Villamil, Yinsheng Wang, Ajit Jadhav, Zhihao Zhuang, Qiuting Zhang, Andrew S. Rosenthal, Christine A. Ott, Diane K. Luci, Thomas S. Dexheimer, Hongmao Sun, Qin Liang, Hui Xiao
Protein ubiquitination and deubiquitination are central to the control of a large number of cellular pathways and signaling networks in eukaryotes. Although the essential roles of ubiquitination have been established in the eukaryotic DNA damage resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2767a947150ded5085b52204f2b3d9d
https://europepmc.org/articles/PMC4144829/
https://europepmc.org/articles/PMC4144829/
Autor:
Mark A. Villamil, Kelvin H. Lee, Yong Seok Choi, Junjun Chen, Shuyu Hou, Qin Liang, Zhihao Zhuang
Deubiquitinating enzymes (DUBs) are important for the normal function of a number of cellular processes, including transcriptional regulation, cell cycle control, and DNA damage response. The enzymatic activity of DUB is regulated by different mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5fcc4c7c02a7fd111af0ed70abfbd2
https://europepmc.org/articles/PMC3617561/
https://europepmc.org/articles/PMC3617561/
Autor:
David J. Maloney, Yongxing Ai, Mark A. Villamil, Ajit Jadhav, Thomas S. Dexheimer, Junjun Chen, Anton Simeonov, Zhihao Zhuang, James Inglese, Qin Liang
Summary Ubiquitin-specific proteases (USPs) have in recent years emerged as a promising therapeutic target class. We identified selective small-molecule inhibitors against a deubiquitinase complex, the human USP1/UAF1, through quantitative high throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53aa7cee81bc58b52b27e12655d2f83
https://europepmc.org/articles/PMC3344384/
https://europepmc.org/articles/PMC3344384/
Autor:
Andrew S. Rosenthal, David J. Maloney, Ajit Jadhav, Thomas S. Dexheimer, Mark A. Villamil, Diane K. Luci, Zhihao Zhuang, Anton Simeonov, Qin Liang
Publikováno v:
Cancer Research. 74:LB-11
Protein ubiquitination is a dynamic and reversible post-translational modification that has been linked to many essential cellular processes in eukaryotes. In addition, deregulation of ubiquitin conjugation or deconjugation has been implicated in the