Zobrazeno 1 - 10
of 458
pro vyhledávání: '"Mark A. Sussman"'
Publikováno v:
Addiction and Health, Vol 15, Iss 1, Pp 23-30 (2023)
Background: Trends in young adult use of electronic nicotine delivery systems (ENDS) and experimentation with do-it-yourself (DIY) e-juice mixing are growing around the world. Theoretical frameworks for examining secondary behaviors (i.e., mixing) em
Externí odkaz:
https://doaj.org/article/e62c7f718bc048f5bb63233bf8e848b3
Autor:
Megan M. Monsanto, Bingyan J. Wang, Zach R. Ehrenberg, Oscar Echeagaray, Kevin S. White, Roberto Alvarez, Kristina Fisher, Sharon Sengphanith, Alvin Muliono, Natalie A. Gude, Mark A. Sussman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Despite recent progress to advance cardiac cell-based therapy for patients, heart failure mortality rivals most cancers. Here, the authors describe an approach to control and pattern 3 distinct human cardiac cell populations to promote superior repai
Externí odkaz:
https://doaj.org/article/d8965aba695e4b73854957d83edbac8e
Autor:
Bingyan J. Wang, Roberto Alvarez Jr, Alvin Muliono, Sharon Sengphanith, Megan M. Monsanto, Joi Weeks, Roberto Sacripanti, Mark A. Sussman
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 5, Pp 620-635 (2020)
Abstract Cardiac interstitial cells (CICs) perform essential roles in myocardial biology through preservation of homeostasis as well as response to injury or stress. Studies of murine CIC biology reveal remarkable plasticity in terms of transcription
Externí odkaz:
https://doaj.org/article/6296ffd372194ebf9ccec5863887ba70
Autor:
Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa, Irene C. Turnbull
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investi
Externí odkaz:
https://doaj.org/article/9a9bde06e28e4ec3b138f70b770bbe62
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
Cardiomyopathy is a leading cause of early mortality in Duchenne muscular dystrophy (DMD). There is a need to gain a better understanding of the molecular pathogenesis for the development effective therapies. Exosomes (exo) are secreted vesicles and
Externí odkaz:
https://doaj.org/article/405ff892a99241988fcfad6b9d67a997
Autor:
Fareheh Firouzi, Sarmistha Sinha Choudhury, Kathleen Broughton, Adriana Salazar, Barbara Bailey, Mark A. Sussman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 1 (2020)
Background CardioChimeras produced by fusion of murine c‐kit+ cardiac interstitial cells with mesenchymal stem cells promote superior structural and functional recovery in a mouse model of myocardial infarction compared with either precursor cell a
Externí odkaz:
https://doaj.org/article/2a9f99fbed5f48dca405cecc5c08e4ac
Autor:
David E. Ebeid, Fareheh Firouzi, Carolina Y. Esquer, Julian M. Navarrete, Bingyan J. Wang, Natalie A. Gude, Mark A. Sussman
Publikováno v:
Cells, Vol 9, Iss 9, p 2001 (2020)
Enhancing cardiomyocyte survival is crucial to blunt deterioration of myocardial structure and function following pathological damage. PIM1 (Proviral Insertion site in Murine leukemia virus (PIM) kinase 1) is a cardioprotective serine threonine kinas
Externí odkaz:
https://doaj.org/article/7f94c897a08a4ad782a530b58c5a5d0d
Autor:
Veronica Sacchi, Bingyan J. Wang, Dieter Kubli, Alexander S. Martinez, Jung‐Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S. Malter, Yijun Yang, Polina Gross, Chen Zhang, Steven Houser, Marcello Rota, Mark A. Sussman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 10 (2017)
BackgroundAberrant Ca2+ handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca2+ handling is essential for the development of strategies to blunt pathological changes in calcium dynamics.
Externí odkaz:
https://doaj.org/article/6a2db19b32c94847a8eac79c834c6bb5
Publikováno v:
Genomics. 113:3705-3717
Ex vivo expansion of cells is necessary in regenerative medicine to generate large populations for therapeutic use. Adaptation to culture conditions prompt an increase in transcriptome diversity and decreased population heterogeneity in cKit+ cardiac
Autor:
Hong Yi, Min Goo Lee, Sangsung Kim, Yoshiaki Tanaka, Hun-Jun Park, Kyuwon Cho, Young Sup Yoon, Patrick Tae Joon Hwang, Mark A. Sussman, Seongho Bae, Jaeyeaon Cho, Ho-Wook Jun, Richard P. Harvey, In-Hyun Park, Hee Cheol Cho, Eric Shin, Rebecca D. Levit, Ji Woong Han, Woongchan Rah, Jae kyung Jung, Hyein Lee, Sang Wook Lee, Nam Kyun Kim, Dong Hoon Shin
Publikováno v:
Nat Biomed Eng
Fibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth muscle cells. Here, we report the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling these three cell types via the microRNA-mimic