Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark A. Stamnes"'
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Treatment of fungal infections associated with the filamentous fungus Aspergillus fumigatus is becoming more problematic as this organism is developing resistance to the main chemotherapeutic drug at an increasing rate. Azole drugs represent
Externí odkaz:
https://doaj.org/article/2d15640287714dd7b6f8e24fe956b63a
Autor:
Laura C. Ristow, Andrew J. Jezewski, Benjamin J. Chadwick, Mark A. Stamnes, Xiaorong Lin, Damian J. Krysan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cryptococcus spp. are environmental fungi that first must adapt to the host environment before they can cause life-threatening meningitis in immunocompromised patients. Host CO2 concentrations are 100-fold higher than the external environmen
Externí odkaz:
https://doaj.org/article/4566e417213e44cb95d77a498fd0705a
Autor:
Virginia E. Glazier, Juraj Kramara, Tomye Ollinger, Norma V. Solis, Robert Zarnowski, Rohan S. Wakade, Min-Ju Kim, Gabriel J. Weigel, Shen-Huan Liang, Richard J. Bennett, Melanie Wellington, David R. Andes, Mark A. Stamnes, Scott G. Filler, Damian J. Krysan
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effect of Rob
Externí odkaz:
https://doaj.org/article/d9d88ba2cedc4442aa5ec5ea0648059b
Autor:
Tomye L. Ollinger, Bao Vu, Daniel Murante, Josie E. Parker, Lucia Simonicova, Laura Doorley, Mark A. Stamnes, Steven L. Kelly, P. David Rogers, W. Scott Moye-Rowley, Damian J. Krysan
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limi
Externí odkaz:
https://doaj.org/article/104337156c65484e8e5a4480cb3c0aa2
Autor:
Marion Vanneste, Qin Huang, Mengshi Li, Devon Moose, Lei Zhao, Mark A. Stamnes, Michael Schultz, Meng Wu, Michael D. Henry
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract Epithelial-to-mesenchymal transition (EMT) is implicated in cancer metastasis and drug resistance. Specifically targeting cancer cells in an EMT-like state may have therapeutic value. In this study, we developed a cell imaging-based high-con
Externí odkaz:
https://doaj.org/article/81d4fbdb3f094595b0c61a1302ce2102
Publikováno v:
SoftwareX, Vol 9, Iss , Pp 154-160 (2019)
Genetic screens using shRNA, CRISPR, or cDNA libraries rely on adequately transferring the library into cells for further assay. These libraries can have many different elements and each element can be present at different copy numbers within a given
Externí odkaz:
https://doaj.org/article/a0a4443e8bec4cb6b5d58af650812822
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The regulation of Ace2 and morphogenesis (RAM) pathway is an important regulatory network in the human fungal pathogen Candida albicans. The RAM pathway’s two most well-studied components, the NDR/Lats kinase Cbk1 and its putative substrat
Externí odkaz:
https://doaj.org/article/deb85dcc8dce42f59a355c8f6a27c60a
Autor:
Anit Shah, Ian Huck, Kaylia Duncan, Erica R. Gansemer, Udayan Apte, Mark A. Stamnes, D. Thomas Rutkowski
Publikováno v:
bioRxiv
In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet ER stress in the liver is uniquely accompanied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf04abed3696da0817e349b47200b3
https://doi.org/10.1101/2023.02.09.527889
https://doi.org/10.1101/2023.02.09.527889
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009582 (2021)
The most commonly used antifungal drugs are the azole compounds, which interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazole via mutat
Externí odkaz:
https://doaj.org/article/2e15523381bb4fc399fa53d9a69a1cda
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96647 (2014)
Juvenile Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL) is a devastating neurodegenerative disease caused by mutations in CLN3, a protein of undefined function. Cell lines derived from patients or mice with CLN3 deficiency have impair
Externí odkaz:
https://doaj.org/article/d567a09372c84f5384d95117aaf8a244