Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Mark A. Schembri"'
Autor:
Nchafatso G. Obonyo, Sainath Raman, Jacky Y. Suen, Kate M. Peters, Minh-Duy Phan, Margaret R. Passmore, Mahe Bouquet, Emily S. Wilson, Kieran Hyslop, Chiara Palmieri, Nicole White, Kei Sato, Samia M. Farah, Lucia Gandini, Keibun Liu, Gabriele Fior, Silver Heinsar, Shinichi Ijuin, Sun Kyun Ro, Gabriella Abbate, Carmen Ainola, Noriko Sato, Brooke Lundon, Sofia Portatadino, Reema H. Rachakonda, Bailey Schneider, Amanda Harley, Louise E. See Hoe, Mark A. Schembri, Gianluigi Li Bassi, John F. Fraser
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-20 (2024)
Abstract Background Escherichia coli is the most common cause of human bloodstream infections and bacterial sepsis/septic shock. However, translation of preclinical septic shock resuscitative therapies remains limited mainly due to low-fidelity of av
Externí odkaz:
https://doaj.org/article/c03348cdf8dc412a96c6356e9237ed0f
Autor:
Fabrice E. Graf, Richard N. Goodman, Sarah Gallichan, Sally Forrest, Esther Picton-Barlow, Alice J. Fraser, Minh-Duy Phan, Madalitso Mphasa, Alasdair T. M. Hubbard, Patrick Musicha, Mark A. Schembri, Adam P. Roberts, Thomas Edwards, Joseph M. Lewis, Nicholas A. Feasey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Infections with Enterobacterales (E) are increasingly difficult to treat due to antimicrobial resistance. After ceftriaxone replaced chloramphenicol (CHL) as empiric therapy for suspected sepsis in Malawi in 2004, extended-spectrum beta-lact
Externí odkaz:
https://doaj.org/article/a653d1fed48c4d248ed8875692a5b104
Autor:
Nguyen Thi Khanh Nhu, M. Arifur Rahman, Kelvin G. K. Goh, Seung Jae Kim, Minh-Duy Phan, Kate M. Peters, Laura Alvarez-Fraga, Steven J. Hancock, Chitra Ravi, Timothy J. Kidd, Matthew J. Sullivan, Katharine M. Irvine, Scott A. Beatson, Matthew J. Sweet, Adam D. Irwin, Jana Vukovic, Glen C. Ulett, Sumaira Z. Hasnain, Mark A. Schembri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent ev
Externí odkaz:
https://doaj.org/article/0c835c379e9d49008c3aba49b38fd4c2
Autor:
Minh-Duy Phan, Horst Joachim Schirra, Nguyen Thi Khanh Nhu, Kate M. Peters, Sohinee Sarkar, Luke P. Allsopp, Maud E. S. Achard, Ulrike Kappler, Mark A. Schembri
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Urinary tract infections (UTIs) are one of the most common bacterial infections in humans, with ~400 million cases across the globe each year. Uropathogenic Escherichia coli (UPEC) is the major cause of UTI and increasingly associated with a
Externí odkaz:
https://doaj.org/article/a687fc2675674903803964d0b2c45e8d
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a
Externí odkaz:
https://doaj.org/article/6d65b18b91de403488fe5eca204df6be
Publikováno v:
Microbiology Australia, Vol 44, Iss 2, Pp 109-112 (2023)
Urinary tract infection (UTI) is one of the most common infectious diseases, with a global annual incidence of ~175 million cases. Uropathogenic Escherichia coli (UPEC) is the major cause of UTI (>80%) and increasingly associated with rising antibiot
Externí odkaz:
https://doaj.org/article/1fd5cd18762849cb8bbe9999ffd442a4
Autor:
Zheng Jie Lian, Minh-Duy Phan, Steven J. Hancock, Nguyen Thi Khanh Nhu, David L. Paterson, Mark A. Schembri
Publikováno v:
PLoS Genetics, Vol 19, Iss 6 (2023)
Plasmids are major drivers of increasing antibiotic resistance, necessitating an urgent need to understand their biology. Here we describe a detailed dissection of the molecular components controlling the genetics of I-complex plasmids, a group of an
Externí odkaz:
https://doaj.org/article/1ac6e8a83b4a4fc9a619b53cc473b128
Autor:
Julieanne L. Vo, Gabriela C. Martínez Ortiz, Makrina Totsika, Alvin W. Lo, Steven J. Hancock, Andrew E. Whitten, Lilian Hor, Kate M. Peters, Valentin Ageorges, Nelly Caccia, Mickaël Desvaux, Mark A. Schembri, Jason J. Paxman, Begoña Heras
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract The formation of aggregates and biofilms enhances bacterial colonisation and infection progression by affording protection from antibiotics and host immune factors. Despite these advantages there is a trade-off, whereby bacterial disseminati
Externí odkaz:
https://doaj.org/article/349e75192df143f99a4bfd28d161e466
MicroPIPE: validating an end-to-end workflow for high-quality complete bacterial genome construction
Autor:
Valentine Murigneux, Leah W. Roberts, Brian M. Forde, Minh-Duy Phan, Nguyen Thi Khanh Nhu, Adam D. Irwin, Patrick N. A. Harris, David L. Paterson, Mark A. Schembri, David M. Whiley, Scott A. Beatson
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Oxford Nanopore Technology (ONT) long-read sequencing has become a popular platform for microbial researchers due to the accessibility and affordability of its devices. However, easy and automated construction of high-quality bact
Externí odkaz:
https://doaj.org/article/8e68f7d374894149918f2d2a4f937ad0
Autor:
Leah W. Roberts, Patrick N. A. Harris, Brian M. Forde, Nouri L. Ben Zakour, Elizabeth Catchpoole, Mitchell Stanton-Cook, Minh-Duy Phan, Hanna E. Sidjabat, Haakon Bergh, Claire Heney, Jayde A. Gawthorne, Jeffrey Lipman, Anthony Allworth, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, Mark A. Schembri, David L. Paterson, Scott A. Beatson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Antibiotic-resistant bacteria are an urgent threat to human health. Here, Roberts et al. characterise and monitor an ongoing hospital outbreak of carbapenemase-producing Enterobacter hormaechei by integrating several technologies for whole-genome seq
Externí odkaz:
https://doaj.org/article/6949f013d6be46a48b44edac95d2071f