Zobrazeno 1 - 10
of 1 190
pro vyhledávání: '"Mark A. Rubin"'
Autor:
Dilara Akhoundova, Stefanie Fischer, Joanna Triscott, Marika Lehner, Phillip Thienger, Sina Maletti, Muriel Jacquet, Dinda S.H. Lubis, Lukas Bubendorf, Wolfram Jochum, Mark A. Rubin
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin s
Externí odkaz:
https://doaj.org/article/ab8d7da124964dd89f2c5fdc280d36be
Autor:
Ivana Bratic Hench, Luca Roma, Floriana Conticelli, Lenard Bubendorf, Byron Calgua, Clémentine Le Magnen, Salvatore Piscuoglio, Mark A. Rubin, Alin Chirindel, Guillaume P. Nicolas, Tatjana Vlajnic, Tobias Zellweger, Arnoud J. Templeton, Frank Stenner, Christian Ruiz, Cyrill Rentsch, Lukas Bubendorf
Publikováno v:
Cancers, Vol 16, Iss 1, p 45 (2023)
Most men with prostate cancer (PCa), despite potentially curable localized disease at initial diagnosis, progress to metastatic disease. Despite numerous treatment options, choosing the optimal treatment for individual patients remains challenging. B
Externí odkaz:
https://doaj.org/article/bad39937c4cc4a99a63b94715549f0a0
Autor:
Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The diagnosis of prostate cancer brain metastasis (PCBM) has increased. Here, the authors investigate the landscape of somatic genetic alterations in brain metastases in a PCBM cohort of 51 patients with non-synchronous matched primary samples availa
Externí odkaz:
https://doaj.org/article/42966ddd44de4ed4a87861f3d4c3176c
Autor:
Toby Ryman‐Tubb, Jennifer H. Lothion‐Roy, Veronika M. Metzler, Anna E. Harris, Brian D. Robinson, Albert A. Rizvanov, Jennie N. Jeyapalan, Victoria H. James, Gary England, Catrin S. Rutland, Jenny L. Persson, Lukas Kenner, Mark A. Rubin, Nigel P. Mongan, Simone deBrot
Publikováno v:
Veterinary Medicine and Science, Vol 8, Iss 1, Pp 110-120 (2022)
Abstract Though relatively rare in dogs, prostate cancer (PCa) is the most common non‐cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has
Externí odkaz:
https://doaj.org/article/72e9d9bfc7304f5da0ca9974da17a621
Autor:
Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia, Andrea Rinaldi, Ricardo Pereira Mestre, Eugenia D’Antonio, Matteo Ferrari, Flavio Stoffel, Fernando Jermini, Silke Gillessen, Lukas Bubendorf, Peter Schraml, Arianna Calcinotto, Eva Corey, Holger Moch, Martin Spahn, George Thalmann, Marianna Kruithof-de Julio, Mark A. Rubin, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH
Externí odkaz:
https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3
Autor:
Chandrani Mukhopadhyay, Chenyi Yang, Limei Xu, Deli Liu, Yu Wang, Dennis Huang, Lesa Dayal Deonarine, Joanna Cyrta, Elai Davicioni, Andrea Sboner, Brian. D. Robinson, Arul M. Chinnaiyan, Mark A. Rubin, Christopher E. Barbieri, Pengbo Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenes
Externí odkaz:
https://doaj.org/article/3fedf5b03c0240298b8eebd7424bc58a
Autor:
Mayumi Sugita, David C. Wilkes, Rohan Bareja, Kenneth W. Eng, Sarah Nataraj, Reyna A. Jimenez-Flores, LunBiao Yan, Jeanne Pauline De Leon, Jaclyn A. Croyle, Justin Kaner, Swathi Merugu, Sahil Sharma, Theresa Y. MacDonald, Zohal Noorzad, Palak Panchal, Danielle Pancirer, Shuhua Cheng, Jenny Z. Xiang, Luke Olson, Koen Van Besien, David S. Rickman, Susan Mathew, Wayne Tam, Mark A. Rubin, Himisha Beltran, Andrea Sboner, Duane C. Hassane, Gabriela Chiosis, Olivier Elemento, Gail J. Roboz, Juan Miguel Mosquera, Monica L. Guzman
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract The epichaperome is a new cancer target composed of hyperconnected networks of chaperome members that facilitate cell survival. Cancers with an altered chaperone configuration may be susceptible to epichaperome inhibitors. We developed a flo
Externí odkaz:
https://doaj.org/article/9b26f08bf6d444edb5f3140c7fcddf4c
Autor:
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render pros
Externí odkaz:
https://doaj.org/article/f2c4c2cbe140413794b564af2e6c8775
Autor:
Sofia Karkampouna, Federico La Manna, Andrej Benjak, Mirjam Kiener, Marta De Menna, Eugenio Zoni, Joël Grosjean, Irena Klima, Andrea Garofoli, Marco Bolis, Arianna Vallerga, Jean-Philippe Theurillat, Maria R. De Filippo, Vera Genitsch, David Keller, Tijmen H. Booij, Christian U. Stirnimann, Kenneth Eng, Andrea Sboner, Charlotte K. Y. Ng, Salvatore Piscuoglio, Peter C. Gray, Martin Spahn, Mark A. Rubin, George N. Thalmann, Marianna Kruithof-de Julio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therap
Externí odkaz:
https://doaj.org/article/74f8126482f64e7aa57d9156cdf767c0
Autor:
Aram Vosoughi, Tuo Zhang, Kyrillus S. Shohdy, Panagiotis J. Vlachostergios, David C. Wilkes, Bhavneet Bhinder, Scott T. Tagawa, David M. Nanus, Ana M. Molina, Himisha Beltran, Cora N. Sternberg, Samaneh Motanagh, Brian D. Robinson, Jenny Xiang, Xiao Fan, Wendy K. Chung, Mark A. Rubin, Olivier Elemento, Andrea Sboner, Juan Miguel Mosquera, Bishoy M. Faltas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The role of germline variation in human cancers is not fully understood. Here, the authors define the landscape of putative deleterious germline variants that abrogate tumor suppressor proteins in advanced urothelial cancer patients.
Externí odkaz:
https://doaj.org/article/841aaee60ec54eb68cb48ba20fbccfd4